Hi Cuffs, I do not have enough experience to say I really noticed a difference--unless you consider a lack of any noticeable sides as "a difference" (if you get my point). Like most other people, I added it to get anabolic properties out of what is essentially an aromatase inhibitor, and it did seem to perform as it was supposed to. I got about the same gains (give or take 1/2 lb.) out of a 1-T/4-AD/4-OHT transdermal cycle in 4 weeks that I got out of an M 1-T cycle in two weeks without the bloat, lethargy, shortness of breath, or itchy nips that I got from M 1-T.