2016 Resveratrol science

John Smeton

John Smeton

Legend
I used to keep up with the studies. The sirt1 anti going gene Then, something came out that said the studies were Faked or something

Is Resveratrol worth taking, in an effort to keep the body, face, younger? any other benefits?
 
John Smeton said:
Thanks for chiming in

what potential negatives?
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Any excessive anti oxidant supplementation isn't good but resveratrol was singled out here "Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men" Invalid Link Removed
 
It was a big fad that got everyone excited, but to keep it short and sweet, there is no science that is compelling enough to shell out any money for this ingredient.
 
I still like Sustain Alpha but it isn't marketed for anti-aging/life extention. For me the benefits of SA easily outweigh the negatives of resveratrol. I cant immagine the effect on exercise being that significant. Probably neglagable in comparison to proper, or the lack of proper exercise and nutrition.
 
If you have alzheimers it may be beneficial. It is in phase II trials, and as you pointed out they are pushing it as a SIRT1 drug, but it is also an arginase inhibitor - and arginase inhibition may reverse alzheimers. There are some leaps in logic, but if you can't get your hands on DMFO, it's a natural, supposed arginase inhibitor.
 
A lot of things screw up training adaptations too. Any Anti-Oxidant use close to training, those stupid Ice Baths you see the MMA and Baseball/Football guys do, etc...
 
The_Old_Guy said:
A lot of things screw up training adaptations too. Any Anti-Oxidant use close to training, those stupid Ice Baths you see the MMA and Baseball/Football guys do, etc...
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We seem to be on the same page these days. Maybe a few different views and slight disagreements, but always very close.
 
HIT4ME said:
If you have alzheimers it may be beneficial. It is in phase II trials, and as you pointed out they are pushing it as a SIRT1 drug, but it is also an arginase inhibitor - and arginase inhibition may reverse alzheimers. There are some leaps in logic, but if you can't get your hands on DMFO, it's a natural, supposed arginase inhibitor.
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Funny I was researching natural arginase inhibitors the other night, and piceatannol came up in a study as the best contender. Resveratrol converts into piceatannol. Just another benefit to using Sustain Alpha. Especially since I am experimenting with Pine Bark and L-Citrulline. That is the reason I wanted an arginase inhibitor, to help facilitate the effects of that combo.
 
Ive used sustain alpha

Ive used resveratrol for a few years on and off. even used it on trt as may have some serm like effects

I thought potent anti-oxidants are a good thing

so dont take it post workout, maybe with the first meal, and even then not sure if any benefit?

I like the Alzheimer preventative,or reverse it? if it can help-that I would think it would be good

so small of a benefit that it doesnt mater?
 
John Smeton said:
Ive used sustain alpha

Ive used resveratrol for a few years on and off. even used it on trt as may have some serm like effects

I thought potent anti-oxidants are a good thing

so dont take it post workout, maybe with the first meal, and even then not sure if any benefit?

I like the Alzheimer preventative,or reverse it? if it can help-that I would think it would be good

so small of a benefit that it doesnt mater?
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Too many anti oxidants can interfere with the body's natural adaptations to stress. Just eat blueberries and you will be getting whatever benefits the anti oxidants can provide and they've been shown to help memory Invalid Link Removed
 
Ape McGrapes said:
Funny I was researching natural arginase inhibitors the other night, and piceatannol came up in a study as the best contender. Resveratrol converts into piceatannol. Just another benefit to using Sustain Alpha. Especially since I am experimenting with Pine Bark and L-Citrulline. That is the reason I wanted an arginase inhibitor, to help facilitate the effects of that combo.
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Not sure resveratrol "converts" to piceatanol but piceatanol is certainly similar and potentially more potent - but extremely expensive and harder to source. Norvaline is another potent Arg. Inhibitor. Probably more potent I believe than any of the above.

Citrulline may increase arginine levels, but I'm not sure it is an inhibitor. Agmatine is another good product but not an arginine inhibitor.

John Smeton said:
Ive used sustain alpha

Ive used resveratrol for a few years on and off. even used it on trt as may have some serm like effects

I thought potent anti-oxidants are a good thing

so dont take it post workout, maybe with the first meal, and even then not sure if any benefit?

I like the Alzheimer preventative,or reverse it? if it can help-that I would think it would be good

so small of a benefit that it doesnt mater?
Click to expand...

Recent research used DMFO and it reversed AD in RATS. And within this thread, Synapsin is the most qualified to discuss any disease and especially a neurological disease like AD, but I've been researching because I know someone with AD.

Resveratrol at 1-2 :/ day has shown promise in AD trials. Along with piceatanol and grape seed extract. On one hand, I believe the bioavailability of resveratrol is very low, yet these studies seem (to me) to show a positive effect. Curcumin has similar issues and is still effective.

If I were concerned about AD, I would try to source piceatanol. But my formula I would love to see someone with AD try:

Resveratrol @ 2 g/ day
Norvaline @ 200-300 mg/day
Agmatine @ 1-1.5g per day.

Agmatine is a metabolite of arginine that retains much of arginine's functionality. My jump in logic is that since it crosses the BBB and arginine does not, and it has these characteristics, it may reduce the direct need for arginine (since there is a shortage if we are inhibiting the enzyme that breaks it down)...

And it turns out there are studies suggesting Agmatine reduces symptoms of dementia.

This theory also ties AD to cardiovascular disease, which studies have been linking together for a while.

Synapsin may tell me I am completely off...and I would love to discuss it if I am.

johnnyp said:
Too many anti oxidants can interfere with the body's natural adaptations to stress. Just eat blueberries and you will be getting whatever benefits the anti oxidants can provide and they've been shown to help memory Invalid Link Removed
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Blueberries aren't as good as cocoa...and just being an anti oxidant isn't the only function of many chemicals. As above, not every anti oxidant is an arginine inhibitor, for instance. But blueberries are a good anti oxidant and generally good for you. Hmmmm, blueberries and chocolate.
 
HIT4ME said:
Recent research used DMFO and it reversed AD in RATS. And within this thread, Synapsin is the most qualified to discuss any disease and especially a neurological disease like AD, but I've been researching because I know someone with AD.

Resveratrol at 1-2 :/ day has shown promise in AD trials. Along with piceatanol and grape seed extract. On one hand, I believe the bioavailability of resveratrol is very low, yet these studies seem (to me) to show a positive effect. Curcumin has similar issues and is still effective.

If I were concerned about AD, I would try to source piceatanol. But my formula I would love to see someone with AD try:

Resveratrol @ 2 g/ day
Norvaline @ 200-300 mg/day
Agmatine @ 1-1.5g per day.

Agmatine is a metabolite of arginine that retains much of arginine's functionality. My jump in logic is that since it crosses the BBB and arginine does not, and it has these characteristics, it may reduce the direct need for arginine (since there is a shortage if we are inhibiting the enzyme that breaks it down)...

And it turns out there are studies suggesting Agmatine reduces symptoms of dementia.

This theory also ties AD to cardiovascular disease, which studies have been linking together for a while.

Synapsin may tell me I am completely off...and I would love to discuss it if I am.
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I could talk about AD for hours haha, so it would be easier to answer specific questions tbh. IMO AD is so multi-faceted that there are a ton of different things to consider. On the topic of arginase inhibitors, yeah, they definitely have some really cool work on it related to AD. A major issue is that tackling beta amyloid plaques and tau proteins are not really the only effective ways to think of AD conceptually IMO (my point is that this has a point of focus for a long time now, and doesn't seem to really be going anywhere clinically significant towards a treatment). That dose of resveratrol is extremely expensive tbh for a "maybe", and norvaline unfortunately would probably not be of any benefit.
 
HIT4ME said:
Not sure resveratrol "converts" to piceatanol but piceatanol is certainly similar and potentially more potent - but extremely expensive and harder to source. Norvaline is another potent Arg. Inhibitor. Probably more potent I believe than any of the above.

Citrulline may increase arginine levels, but I'm not sure it is an inhibitor. Agmatine is another good product but not an arginine inhibiter
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resveratrol is converted to piceatannol by the cytochrome P450 enzyme CYP1B1
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To be fair I didnt read the whole study.

And yes citrulline isn't an arginine inhibitor. It is a classic ingrediant for erection quality, especially combined with pycnogenol/pine bark.
 
Synapsin said:
I could talk about AD for hours haha, so it would be easier to answer specific questions tbh. IMO AD is so multi-faceted that there are a ton of different things to consider. On the topic of arginase inhibitors, yeah, they definitely have some really cool work on it related to AD. A major issue is that tackling beta amyloid plaques and tau proteins are not really the only effective ways to think of AD conceptually IMO (my point is that this has a point of focus for a long time now, and doesn't seem to really be going anywhere clinically significant towards a treatment). That dose of resveratrol is extremely expensive tbh for a "maybe", and norvaline unfortunately would probably not be of any benefit.
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This is my feeling exactly on the Amyloid/Tau symptoms. One day In started asking myself, what if those build ups are not actually AD at all, but our body's response to AD? Then I found some recemt research showing that those plaques actually have some kind of antibiotic effect. Couple this with the fact that many diseases cause the over expression of Arginase in order to defeat the immune system...and it's just more evidence in that direction.

It just seems to me that the evidence is pointing more and more to a cardiovascular, or at least systemic, issue when we have been treating it like it happens in the brain only.

And yes, it is most likely multifaceted...but I think arg inhibition is very promising as a big factor.

And yes, 2 g of resveratrol/day is expensive. Piceattanol would be even harder to find and more expensive. But for someone with AD, it could be worth the maybe.

Why don't you think norvaline would work? You may be right. But it seems like it works well for cardiovascular arginase inhibition.

Thanks for the discussion Synapsin and sorry if this has kind of hijacked the thread..
 
619sss said:
Not sure why but at 400mg trans-Resveratrol I lost my libido. Maybe it was too high...
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I believe there is some effect on estrogen with resveratrol - I havent researched it for hormones so much. Above in this thread it was mentioned as a SERM.
 
johnnyp said:
Too many anti oxidants can interfere with the body's natural adaptations to stress. Just eat blueberries and you will be getting whatever benefits the anti oxidants can provide and they've been shown to help memory Invalid Link Removed
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Blueberry is interesting, as it is high in antioxidants, but a study found that consuming a blueberry smoothie before and after exercise-induced muscle damage actually:
accelerates recovery of muscle peak isometric strength. This effect, although independent of the beverage’s inherent antioxidant capacity, appears to involve an up-regulation of adaptive processes, i.e. endogenous antioxidant processes, activated by the combined actions of the eccentric exercise and blueberry consumption. These findings may benefit the sporting community who should consider dietary interventions that specifically target health and performance adaptation.
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Interesting find. I have consumed blueberries in my post workout shake for years and never encountered any issues, but admittedly, would not know what I would expect.
 
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