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  1. TheProfessor

    Does anybody have a good calf routine

    Once you go primal with weight training. YOU NEVER GO BACK!
  2. TheProfessor

    Does anybody have a good calf routine

    I go to the types of gyms where they don't let you in UNLESS you scare women :-p I'm a strength athlete. So I train at a gym for strength athletes. Also in my garage, where I can train naked, with boots on, and make as much noise as I want. That alone puts on muscle mass. If you want to get...
  3. TheProfessor

    Does anybody have a good calf routine

    It's a neck/forearms/calves 1:1:1 methinks But in reality, calves can never be too big :-p
  4. TheProfessor

    Does anybody have a good calf routine

    owwieeeeeee
  5. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    What I can say is this. Bodybuilders were at a standstill (size wise) until the 90's or so until recombinant proteins became widely available. They went from huge to stupid. I just agree with jonny, most of that stuff is just speculatory at this point. Take that for what it's worth.
  6. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    This might be of interest to somebody. Particularly Jonny as it is about ostarine Invalid Link Removed
  7. TheProfessor

    Does anybody have a good calf routine

    Farmers walk ;) Yoke walk Best thing that every happened to my calves. Walk around with 350 in each hand for sets of 80 feet. Those bitches'll grow!
  8. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    That's out of the scope of my education. I don't like to hazard guesses at most physiological things like that. I find it very interesting, it's not something I really like to comment on. Although I could probably dig up some publications for you if you want. I just don't feel comfortable giving...
  9. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    I'm out for the night, but I'll get to it if anything else comes up tomorrow.
  10. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Just for clarification, more muscle mass is not equal to more muscle cells. The cells grow. Having new cells come about is entirely a different monster. that's out of the scope of the thead. And as a rule of thumb, the body will always take the easy way out. It's much easier to stop making...
  11. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Increasing the amount of total muscle cells you have would allow you to create more androgen receptors ;) I'm not convinced that the effectiveness of AAS will be increased THAT MUCH. there is no reason to increase the amount of androgen receptors you have when you are off cycle because you...
  12. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    I think time off of a PH cycle more has to do with liver stress than anything else. People are on test for years and years and years (and years). From what I can tell, LCLT doesn't increase AR sensitivity, it just increases the amount of AR receptors, which allows more total androgens to bind...
  13. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    This is my OPINION. Considering how giant people can get with the use of AAS. I don't think desensitization of the AR should be a concern. Some guys are on year-round and they grow and grow. Could it get desensitized through AAS use? Maybe. enough to cause you to shrivel? Not likely. I don't...
  14. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    If you have any other biochemistry related questions PLEASE lay them on me. I'm just accumulating as much information as possible and questions like this just give me more tentacles to reach around with.
  15. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    DHT is the reason for damn near all sex characteristics. For some crazy ass reason, DHT causes much more transcription levels in the sex organs than any other compound ( at least endogenously). DHT and testosterone look damn near identical, and the conformation of the androgen receptor has...
  16. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Yes, these are effective anti-androgen SARMS. And yes, I agree with the second part. I am pretty sure long term use of anti-androgens can cause hormone-refraction. Those genes in the androgen response element NEED to be expressed. If you want to keep your hair you can attempt. But there are...
  17. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Well, technically there are 2 isoforms of the AR, but from what I remember, it doesn't even have the ligand binding domain :-p The tissue selectivity involved with the estrogen receptor is most definitely driven by the fact that there are TWO FORMS of the estrogen receptor. AND the fact that...
  18. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Androgen insensitivity syndrome definitely disease syndrome I can think of with a genetic component. Although not caused by single nucleotide polymorphisms. There are heavier genetic issues with these people. Most of the SNPs evaluated within the AR gene had more to do with prostate cancer risk...
  19. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    HOLY CRAP !!! BIOCHEMISTRY QUESTIONS! give me a few minutes to respond.
  20. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    All I really said was adding bulk to the 17a-carbon decreases binding affinity. Just because it works well with a methyl group there doesn't mean it wouldn't work better without the methyl group there...
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