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  1. Therapy for the gut

    Update: The laxative effect of Xylitol has worn off at the dosage I have been taking. It is normal for the laxation threshold to go up but it also seems like anything else I have tried for the gut in that it adapts in such a way to return it to its usual poorly functioning state. Perhaps...

  2. YUP, SHBG 82.4, HELP!!!!!!!

    Labs are far less reliable for hormones than one would expect. The CDC has recently been trying to encourage improvements in the situation. AIs are far less useful tools for E2 manipulation that I expected too. I did not like the sides of either Adex (made me dizzy) or Aromasin (made me weak)...

  3. To Lower shbg, good or bad

    I've read that higher androgens (includes T) is supposed to lower SHBG but the effect for T doesn't seem to be that strong. Other factors seem to be more important (high E for example raises SHBG).

  4. YUP, SHBG 82.4, HELP!!!!!!!

    How do you feel? Did this change in SHBG make any difference? Will you continue with DANAZOL?

  5. Question on some symptoms

    I have similar responses to coffee even when I was young and healthy. A cup of coffee would take 2 to 4 days to clear. I also feel the effects of alcohol longer - usually more fatigue - so I don't drink very much. The funny thing is that having more coffee didn't really have any additional...

  6. Therapy for the gut

    This question implies you are thinking the gut is the primary issue which I do not believe. Going after bacteria was one of the first approaches tried before there even was a gut issue. If it is a bacteria then it is resistant to all antibiotics I have ever tried. I don't think so. Of course...

  7. Therapy for the gut

    I have tried everything you have listed and none of it has much effect on the skin pain. There are some areas that became chronically redder at the onset of the pain but other areas it comes and goes and others not much is visible. None of this looks that unusual (like mild seborrhea) to a...

  8. Therapy for the gut

    To bring this thread back to therapy for the gut I will update my experience with Xylitol. My initial feeling of an improvement in overall well being was short lived. I have many things going on so it is unclear what the right associations are but I do think there was something to its initial...

  9. Therapy for the gut

    , Ankylosing spondylitis is a disease of the skeleton. I have no problems with my joints or spine which is way better than most people my age. As far as I know the disease is not even associated with skin pain. I have not, however, been HLA typed. This is something that I have wanted to do...

  10. Therapy for the gut

    I should say something about my worst symptoms just to give you a better idea what I am up against. My biggest problem has been for years a chronic cutaneous pain. This has progressively affected larger areas of my body. At this point nearly everything except my arms and legs are affected...

  11. Therapy for the gut

    Take a look at the assays at proimmune.com. Several of these would be interesting if done with custom antigens. The problem is that these generally cost real money to do. Something similar for monocytes would be good too.

  12. Therapy for the gut

    I'm glad you know some good people. Does he have access to any research assays for immune function?

  13. Therapy for the gut

    I know I started this thread specifically about gut issues but that does not mean I think my primary issue is the gut. Instead there appears to be a very specific immune deficit. The gut issue is secondary to this and the lymphocyte dysregulation is secondary to this and the gut issue...

  14. Therapy for the gut

    Clinical trials have shown that probiotics don't persist and offer limited benefits. There has been more success with fecal transplants. Yeh, I know - ick.

  15. Therapy for the gut

    The tests that Neuroscience has that are most relevant and I have not already done include: ISA 1 LSA+Treg (actually I have done most of this too) These are too generic - won't get at the root nor will they provide actionable information. Their apoptosis test is useful for monitoring only...

  16. Therapy for the gut

    There are no good treatments for increasing lymphocytes in deficient patients with unknown cause. IL-2 works for some but this is a very nasty treatment and the benefit is usually transient and weak. IL-7 has been in some research trials but it is not available and unclear how useful it would...

  17. Therapy for the gut

    I certainly appreciate wanting to turn over every stone. Unfortunately, one must be practical and narrow down the diagnostic space to the most likely candidates. My symptoms are not consistent with any mitochondrial disease I am aware of so this avenue hasn't been pursued directly apart from...

  18. Therapy for the gut

    We have ~30000 genes and you have suggested only a handful that happen to be clinically available. I have already looked at about 10000 of my genes. The problem you run into with a more comprehensive genetic scan is that even when you find a mutation that looks significant very little may be...

  19. Therapy for the gut

    This is a research assay - not a clinical one - there are no ranges. That is why I reported the results as standard deviations. You can use your judgment about whether being lower than for example 99.85% (~3 SD) of people is abnormal or not. You omitted immunology from you list. That is...

  20. Therapy for the gut

    I had far more extensive cytokine testing done through a Stanford research study. I pasted the results below. The value is the number of standard deviations relative to controls. You will see that I am low across the board - sometimes very low. It is very hard to make sense of these results...
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