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  1. 5 must have supplements for everyday.

    right there are some worrisome studies in rats but until this is proven in humans with physiological doses I don't think curcumin will affect hormones significantly.

  2. 5 must have supplements for everyday.

    I've taken various curcumin formulations - piperine, Meriva, BCM-95. Currently taking Meriva from Thorne, not sure I'm noticing anything. I thought I noticed something weeks ago but I think it was placebo. I'm sure it is good for those with excessive inflammation as the studies do show this, but...

  3. Nootrol vs Nootropimax

    just want to point something out about coffee and caffeine. coffee has a blunted adrenaline response when compared to caffeine at rest in humans, likely due to the chlorogenic acid found in coffee. Cholorgenic acid antagonizes the adenosine receptor binding of caffeine.

  4. How Much Caffeine Do You Take Daily?

    Well for me, with more caffeine comes reduced sleep quality (and of course tolerance). We shouldn't ever really need to rely on caffeine to get through the day. Obviously people have jobs, school, various priorities but we should get our energy from sleeping well, eating well, modulating stress...

  5. How Much Caffeine Do You Take Daily?

    same here... most days, it ends up being a yes. I usually keep it to 16 oz black coffee upon waking (probably around 200 mg) and that is usually it for the day. I should mention I am prone to anxiety and a slow metabolizer of caffeine.

  6. Curcumin – The Real Holy Grail of the Supplement Industry

    I tried getting the full article from Sci-Hub but couldn't find it. :\

  7. Curcumin – The Real Holy Grail of the Supplement Industry

    Curcumin is not likely to have any significant MAO inhibition effect in humans. Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin. 2013 "Although prior work had shown curcumin to function as an inhibitor of the monoamine metabolizing...

  8. 5 essential supplements

    fish oil magnesium glycinate zinc protein powder (casein/whey mix) vitamin D everything else is not necessary for me

  9. Favorite Preworkout ingredients

    Probably coffee, ALCAR, NALT, cdp-choline, citrulline malate, creatine

  10. Ashwagandha increases estrogen?

    and after reading some of the popular ashwagandha studies, in the discussion portion: "Elevated levels of FSH have been correlated with damage to the seminiferous tubules. FSH has been suggested as a marker of Sertoli cell function and spermatogenesis." So excessive FSH = potentially not good.

  11. Ashwagandha increases estrogen?

    bump also, ashwagandha seems to decrease FSH in both rats and males. Should one be worried about this?

  12. Nootrol vs Nootropimax

    A lot of people on the nootropics subreddit actually report these negative effects

  13. Need a new multi vitamin

    Do you log your food so you know which micronutrients you are commonly deficient in?

  14. Ashwagandha increases estrogen?

    I guess that makes sense. But in the study I posted testosterone did not increase in control (healthy non-addicted) rats, although estrogen did.

  15. Ashwagandha increases estrogen?

    Just came across this study from 2016. Granted, it is in rats and I don't believe has been replicated in humans but it was interesting nonetheless. Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats * Ashwagandha treatment in the control group...

  16. Nootrol vs Nootropimax

    300 mg, 45% bacosides. once per day with food

  17. Nootrol vs Nootropimax

    yes. also with tyrosine. similar to melatonin for me but in different aspects. Can't take either melatonin or bacopa, no amount of caffeine seems to overcome the lack of drive and motivation. Also, personally I'm not a huge fan of caffeine, I just stick to a couple cups of coffee.

  18. Nootrol vs Nootropimax

    unfortunately I can't take bacopa - always causes me fatigue and de-motivation.

  19. USP winning my cupboard space, whos winnign yours?

    A little bit of Biotest, Pure Encapsulations and Life Extension.

  20. Curcumin – The Real Holy Grail of the Supplement Industry

    Life Extension is a good brand for sure, they use BCM-95. I know that John Meadows personally uses and recommends it. Right now I am using Thorne Meriva for some achy joints and mood issues, I believe there is a study showing that Meriva is better than BCM for absorption. I do hate how all...
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