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  1. furion

    Im on Ulcer med., need experienced Ulcer input

    Not likely. There is a little evidence in the form of case reports that suggests an endocrine response to PPIs (eg omeprazole) causing gynecomastia- however these are not consistently substantiated with any blood test abnormalities and considering the prevalence of PPI prescribing and the very...
  2. furion

    Im on Ulcer med., need experienced Ulcer input

    Esomeprazole can be taken with or without food- the kinetics aren't changed. Some people, treating GORD, take a PPI before food to establish a high enough blood concentration that will reduce gastric acid secretion before they eat (...and stimulate gastric acid secretion). Others take it before...
  3. furion

    Im on Ulcer med., need experienced Ulcer input

    What dose esomeprazole are you taking? You can go up to 40mg per day in either split or single doses. Are you sure you have an ulcer and not just GORD? I would request a urea breath test to identify if a Helicobacter pylori infection is not the cause. Failing that and assuming absence of more...
  4. furion

    Trt and now thryroid issues?

    There is an association with hypothyroidism and testicular dysfunction- where the latter can present as secondary hypogonadism. This can actually be treated with thyroxine (t4) replacement. Can't say I've ever heard of it occurring the other way around unless there is some form of acquired...
  5. furion

    help-penicillin in pct?

    I would take that article on tamoxifen with a grain of salt- it is thwart with propaganda with a very apparent ulterior motive. Yes there are case reports (I would be very surprised if there are 'thousands') that indicate that tamoxifen can induce liver injury and fatty liver disease-however...
  6. furion

    Androgel to Injectable converstion

    Canberra, certainly the best place in Australia! I would ask to have a peak blood level taken around 4-5 days after administration- then a trough level taken at 2 weeks (dose intervals are ideally calculated off trough levels). I would hedge my bets that after 2 weeks the trough would be...
  7. furion

    help-penicillin in pct?

    I'm not too sure whether he's claiming to be pharmacist- I had a bit of trouble decoded that cryptic response. I think he suggesting that I should move to Norway because I would like the people and would make good money...??? ...maybe.
  8. furion

    Androgel to Injectable converstion

    I have seen significant variances in blood levels between individuals using transdermal testosterone and there is more than just the absorption that influences this (lean body mass/aromatase expression, metabolic enzyme polymorphisms, ect)- so it would be difficult to quantify- I could probably...
  9. furion

    Androgel to Injectable converstion

    Are you using the 5g satchets or 2.5g? In any case, in my experience, 5-10mg transdermal testosterone daily will produce higher more stable serum testosterone than 200-250mg monthly. Your endo is being very conservative- bloods taken after a month will likely not best represent an accurate...
  10. furion

    help-penicillin in pct?

    Your antagonism is ridiculous- considering your argument has no basis other than 'Penicillin is no different'. I could direct you to the appropriate references so you could see how silly your statements are- but I'm almost sure you wouldn't be able to understand them. Didn't want to pull this...
  11. furion

    help-penicillin in pct?

    You are misinterpreting the word 'synthesize' and 'metabolise' - and sounds desperately uneducated by doing so and trying to discredit me. Probably irrelevant information, as you clearly don't understand even very basic pharmacokinetic terminology, but the OP has not even indicated the...
  12. furion

    help-penicillin in pct?

    It's is synthesised in a lab. Is this a trick question?
  13. furion

    help-penicillin in pct?

    I'm assuming you are taking phenoxymethylpenicillin (penicillin V)? It is almost completely renally eliminated and it undergoes very little hepatic metabolism (hydrolysis) which is not subject to interaction as would CYP3A4 substrates when co-administered with Tamoxifen. So there is no concern...
  14. furion

    Hmm... Forskolin Suppresses Expresion of ATGL...

    Interesting paper, however any potential clinical significance pertains only to TSH effects on ATGL- and even then such in vitro results would normally preclude in vivo testing if there was scope for obtaining usable data, which in itself and my opinion, is not exactly dire. From a pathological...
  15. furion

    Very serious ARA question (not joking)

    This is a tricky question- Different arachidonic acid metabolites can act as both bronchodilators (PGe2 PGi2) and bronchoconstrictors (PGd2 and Leukotrienes) As asthma hypersensitivity responses and precipitants are variable and sometimes idiosyncratic- it would be difficult to determine your...
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