Search results

  1. furion

    Best OTC AI

    Now this is out in the open... Thanks to mrcooper69 for the blunt presentation of facts. I also read this paper a little while back when I saw a question regarding the half life- I bit my tongue. Using the area under the curve and the volume of distribution in a rat to human algorithm the half...
  2. furion

    Absoluty best well rounded epi product

    I would say it isn't. There isn't yet established mechanism of actions for the proposed ergogenic benefits- I've speculated as to potential mechanisms in the write up for Epi-Plex (attached) and from my observations it appears apparent that certain methylated phase II metabolites (3' O-methyl...
  3. furion

    Olympus Ep1c vs EGCG supps?

    I'm not convinced that epicatechin is solely responsible for the observed activity and would go as far to say as 'augmenting' bioavailability by inhibiting/bypassing certain phase II hepatic enzymes (using certain bioflavonoids- as you have described) could be detrimental to getting the most out...
  4. furion

    Olympus Ep1c vs EGCG supps?

    Competitive Edge Labs EPI-PLEX- Completely transparent label: 300mg Epicatechin/cap - 60 caps @ the most reasonable price.
  5. furion

    Growth Factor Xt and Xgels

    No the combination would be fine to take together. With the exception of n-3 fatty acids, in terms of anti-inflammatory compounds, it is the inhibition of cyclo-oxygenase-2 that is the is the primary concern when considering compounds that may mitigate ArA effectiveness- as this enzyme is...
  6. furion

    Prolactone vs Inhibit-P

    Parallel would make more sense for both prolactin control and also potentiating the ghrelin stimulated GH secretion from MK 677. The increase in prolactin observed with MK677 is similar to other ghrelin mimetics whereby the initial doses stimulated the greatest peaks- which alone should be...
  7. furion

    Prolactone vs Inhibit-P

    The (hypothetical) research that suggests that co-administration of pyridoxine with L-Dopa reduces central distribution of the dopamine precursor was performed with L- Dopa and not a Mucuna extract. Inhibit-P contains Mucuna standardised to 60% L-Dopa. Mucuna also contains several other...
  8. furion

    What does this mean?.

    Myocardial calcium channel blocking (CCB) activity is actually common with other steroid hormones including testosterone, DHEA and certain estrogens. It is proposed that the mechanism of CCB of epiandrosterone is the same as DHEA- whereby the inhibition of the L-type calcium channel is secondary...
  9. furion

    The Arachidonic Acid Help Guide

    If you were to consider the proposed MOAs of each supplement there would be very good synergism for stimulating and activating protein synthesis via mTOR and ribosomal kinase enzyme activity. ARA: precursor of PGE2 which can activate PI3K/Akt/mTOR pathway HMB: Increase expression of mTOR and...
  10. furion

    The Arachidonic Acid Help Guide

    Although endogenously produced ARA is involved in many disease state pathological cascades- with very little exception, dietary ARA would theoretically not be involved in the origin aetiology of the disease.
  11. furion

    Top 5 "must have supplements?"

  12. furion

    EXOTHERM FAQ

    See this question numerous times for many AI compounds. As far as I understand, one overlying requirement in the structural activity relationship for covalent binding of aromatase is a four ringed cholesterol-like molecule. In regard to plant derived natural compounds- this would include...
  13. furion

    CEL EPI-PLEX Promo

    Working off the premise that it is not only the parent compound that is responsible pharmacological activity- the lipophilic metabolites in particular will have much slower clearance and longer duration of activity. Although the literature doesn't specifically identify, there is correlation...
  14. furion

    CEL EPI-PLEX Promo

    There is a little evidence that indicates that epicatechin may inhibit pancreatic lipase enzymes. The binding kinetics are not exactly specific- but it would be good enough reason to suggest taking it on an empty stomach. Assuming the proposed MOAs in my write up- it wouldn't matter if it were...
  15. furion

    Nootropics

    There is really a paucity of actual credible evidence for long term effects for most of the popular 'racetam' used as nootropics. However there is reasonable data on the levetiracetam (brand name Keppra) as an adjuvant anticonvulsant. If one were to assume this relevant to other racetams...
  16. furion

    SNS RELEASING NOOPEPT XT

    There is evidence to suggest that it may have additive anticonvulsant activity with valproate. However even in the absence of comprehensive evidence I certainly wouldn't recommend using it with anticonvulsant narrow therapeutic indexed medications) eg valproate, lithium, carbamazepine)...
  17. furion

    Interesting information on Bulbine Natalensis

    This is a very preliminary finding and is certainly not conclusive. The histopathological changes noted in rats are more than likely due to the anthraquinone constituents. Other plants containing higher levels of these constituents and more commonly used, such as Senna, Cascara and Aloe, share...
  18. furion

    CEL EPI-PLEX Promo

    No there wouldn't be any interaction. You sound as though you've had this before. I've never really had much success with intra-articular corticosteroids.
  19. furion

    CEL EPI-PLEX Promo

    The write up is more focussed on the actual potential pharmacological activity of epicatechin. Not necessarily specifically to the CEL product. Piperine- as far as the inclusion in the formula? I was not intimately involved in the formulation- but I can tell you that it it was included for...
  20. furion

    CEL EPI-PLEX Promo

    ...the rest (and references) (-)-Epicatechin is capable of augmenting nitric oxide via activating the skeletal muscle expressed neuronal nitric oxide synthase (nNOS) (9,38) and also through inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) by its O-methyl metabolites (39). It...
Back
Top