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  1. Mirtazapine - anabolic/androgenic...?

    My niacinamide dose is 3g spread over a day. As Peat says, this is much more than a simple 'B' vitamin. It must be niacinamide or nicotinamide though - niacin (the flush kind) has the OPPOSITE effect. Here's a brilliant post by a fella called 'Haidut' on another forum: "I will digress...

  2. Mirtazapine - anabolic/androgenic...?

    Ok so GABA is apparently not your issue. My bro is on it for back pain and it really agrees with him. However, I know it's hit and miss with drugs, likely due to the specificity of their actions. As you've tested some dopa drugs with little success, that would leave serotonin ( which is...

  3. Mirtazapine - anabolic/androgenic...?

    Jeffo - no offence taken :-) The first thing that springs to mind is dopamine. Is it possible that your own dopamine production or sensitivity waned, for genetic or other reasons? Dopamine plays a big role in testosterone modulation. It's also the neurotransmitter of sex drive and energy...

  4. Mirtazapine - anabolic/androgenic...?

    Oh - and in combination with DHEA taken in the morning and evening I get better results. DHEA lowers shbg, the effects of cortisol and provides material for hormone production. Everyone is different on dose. For me I find that 25mg is a sufficient dose. Higher, and I feel edgy and wound up...

  5. Mirtazapine - anabolic/androgenic...?

    Hi Jeffo. Yes I can confirm for certain, that for me Mirtazapine is anabolic. After some time I came to the conclusion that it is the ability of this drug to tank cortisol which creates a vacuum filled by it's constant adversary - testosterone. In older men (over 40 I guess) the cortisol...

  6. QUERCETIN for lowering progesterone

    Lowering progesterone: Invalid Link Removed Allergies/mast cells/histamine - quercetin Invalid Link Removed Progesterone increasing shbg Invalid Link Removed Histamine increasing progesterone Invalid Link Removed

  7. QUERCETIN for lowering progesterone

    I've been researching various studies on pubmed, specifically with an interest in histamine and progesterone. Histamine directly promotes an increase in progesterone. Progesterone dirctly promotes an increase in SHBG. This is a self fulfilling function - as SHBG lowers estrogen and...

  8. YUP, SHBG 82.4, HELP!!!!!!!

    I have very high histamine. My shbg came in really high recently. I am on Ketotifen - a mast cell blocker and h1 antagonist that also happens to boost T by preventing it's breakdown AND It also boosts igf1. After a couple of days I feel much better on Keto. I know my T is rising already...

  9. Arimidex/depression?

    Thunder have you had your cortisol checked? I wonder if it is high and keeping E in the driving seat? Cortisol is notoriously resistant to control attempts. However I have found Stablon to be very effective at an hpta reset. When cortisol is cleared, it's main competitor T has the...

  10. Arimidex/depression?

    Blood test results are back. In less than two weeks of arimidex, my testosterone has grown from a borderline trt level of 15, to an amazing top of the range 31. I have actually pulled back to an eighth of a tab per day to lower my a T a little. My E is at 70 - th lower end of normal. My...

  11. Arimidex/depression?

    Hi Thunder All these things look high higher E in ratio to T. The lack of motivation is a classic low dopamine situation. T raises dopamine in a direct correlation and I suspect E attenuates it's activity. Have you tried an AI yet? Even at that, estrogen is one of those chemicals that...

  12. Arimidex/depression?

    Philip et al Apologies for my absence from this thread the last few days. I've been running some self imposed experiments and doing some further research. I had to understand the depressive element of adex better and see if there is any way the mood effect could be ameliorated during use. Adex...

  13. Arimidex/depression?

    Thunder, let me have a wee think about your post and get back to you :-)

  14. Arimidex/depression?

    Philip That is a comprehensive list. My first impression is, how do you shrink a list like that? I'm interested in the hypo pit situation. I'm wondering how much western diet/lifestyle was involved in that decline? This is my basic daily diet at present: 600ml fresh double cream 2...

  15. Arimidex/depression?

    Thanks PM. I have some T3 here, and looking at the myriad of downstream endo disasters from the thyroid, it seems the only way to get back on top of it is to run with T3 for a few weeks and attempt to reboot the thyroid. I drank a litre of soy milk a day for ten years - bye bye optimum...

  16. Arimidex/depression?

    Hi Lex if it is of interest.... After last night's anxiety sensation in my chest, I took half an Adex. Within 1 hour the anxiety sensation was completely gone. Yesterday I took 200mg of pregnenolone in a split dose. Normally I do 50mg am. The increased preg obviously had provided...

  17. Arimidex/depression?

    Of note, my last Adex dose was .5 yesterday morning. I skipped this morning. The chest anxiety sensation just kicked in at 7pm. This tells me I am metabolising my Adex at a rate of about 30 hours, not three days. I know I am making more T thanks to Adex, but that means that any backlash of...

  18. Arimidex/depression?

    Progesterone comes to mind as a complicating factor. A powerful hormone used both as a libido booster and E limiter in men and women. I have read anecdotal reports it may cause male breast tissue issues at higher levels but as a sex hormone it appears to be neutral and any sexual effects...

  19. Arimidex/depression?

    As T falls the mood must be sustained. This means that whatever replaces it, has neurotransmitter capacity. It is an adaptive function. What do 99 out of 100 docs offer an andropause patient before diagnosis - antidepressants for nervous depression. Cortisol is rising, as a primarily stress...

  20. Arimidex/depression?

    For Neo Read this study in detail and see how T and E adapt under the influence of Adex. Yes, there could be mood issues, which are manageable by dose. I think the body adapts in these circumstances and resets levels of endo hormones like cortisol. A comedown from high cortisol (typically...
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