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  1. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    The question wasn't ask me about steroids. It was ask me about the androgen receptor. I'm a biochemist, not a pharmacologist. 1. This paper explicitly states that increasing the carbon length at the 17a-position decreases affinity because the steric clash and hinderance of a hydrogen bond the...
  2. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Technically yes. 1 way is due to genetic disorder where the gene has mutations which prevent androgens from binding properly. Another would have to do with the post translational modifications to the receptor that might inhibit signal transduction or DNA binding to the androgen response...
  3. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    It would be much less difficult if you asked me what you wanted to know. I'm not just going to write a report for you. But if you have SPECIFIC questions I'd be glad to look into it :)
  4. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    I think it's something that is TOTALLY NOT DHSEA compliant :)
  5. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    I misred. You are asking if an orally active trenbolone is possible? Trenbolone was never manufactured for human use. Only agricultural. The reason you never found a methylated derivative is because it was never a drug for humans to begin with. ALthough it is being looked at again for it's...
  6. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    correct alpha alkylation decreases androgen receptor binding capacity. The larger the alkyl group the poorer the binding. It was just a matter of balancing hepatic metabolism and drug function. Frankly, I don't know the compound you are talking about offhand. I don't feel like drawing it out. So...
  7. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    I'm not going to recommend you any steroids lmao. :) I wouldn't take DHT, or anything that converts to DHT in high amounts. I think a certain brand here advertises that all their stuff converts to DHT on purpose. I think that's stilly. But that's just me.
  8. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    There is nothing that I know of that would make steroids have more affinity for the AR. It would likely be possible to cause AR sensitization, but that would NOT be tissue specific, and therefore not advisable in any case. DHT is the strongest endogenous AR agonist. You want to keep in mind...
  9. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    1. You are hard pressed to downregulate any receptor, and even so, it would be very temporary. 2. I can't think of any androgen receptor antagonists off hand that are sold. Especially ones over the counter. If there were, it would (arbitrarily) be more likely to effect the prostate than the...
  10. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    Sarms bind with the androgen receptor but have (supposedly) less interaction with the sex organs that express the androgen receptor. This is because sex organs also express 5a-reductase, which converts testosterone to DHT. Relieving some of the deleterious affects associated with androgen...
  11. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    Unless there are publications that state, I can only hypothesize as I am NOT going to run any SAR programs to answer that question for you. What is the CAS number of this compound? I CAN tell you that adding extra length to the carbon at the 17a position DECREASES the binding capacity of...
  12. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    I posted a quick outline of some general knowledge, I'll keep filling it in as I get time. Too bad none of my formatting was saved when I reposted it. It may spark some questions people have.
  13. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    I PM'ed you.
  14. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    As somebody with your amount of 'wisdom' there are two issues. Not only is your total testosterone lower, your amount of free testosterone is also decreased because the body upregulates proteins responsible for binding your testosterone up. Then what little testosterone you do have, a portion...
  15. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    According to this paper, it increases density post exercises (in skeletal muscle). Whether or not this is beneficial in the long run, meh. There is a chance in increases it in the prostate as well. But I don't know for sure. I might thumb through to see if I can find something. Kraemer, W. J...
  16. TheProfessor

    Ask a biochemist anything! Part Deux: The Androgen Receptor

    I'd prefer to multi-post this to get more viewers but I don't want to get flamed, Ill repost this in the anabolics forum and just remote them back here. 1. I want as many questions as possible 2. I don't know where this thread belongs. Mods can relocate or delete as they wish. I am...
  17. TheProfessor

    Ask a Biochemist anything! Part Deux: The Androgen Receptor

    I'd prefer to multi-post this to get more viewers but I don't want to get flamed, Ill repost this in the anabolics forum and just remote them back here. 1. I want as many questions as possible 2. I don't know where this thread belongs. Mods can relocate or delete as they wish. I am...
  18. TheProfessor

    Why do so many roid boys do natural shows?

    Ok. Aceroni was cool and left a message on my profile so I'll add my official two cents since he clarified the toxicity thing. Bill86: Methylated steroids are not toxic, it is the metabolite of the methylated steroid that is toxic :). Aceroni: The steroid is glucuronidated and it's that...
  19. TheProfessor

    Why do so many roid boys do natural shows?

    agreed. I suppose I should have abandoned my legitimate urge to help when 'retarded' was spelled 'retarted' while simultaneously being called stupid by the same person. Abandoning....... now.
  20. TheProfessor

    Why do so many roid boys do natural shows?

    I'm not justifying anything :). I was literally just trying to understand what he was saying so I can be productive in the thread. But, on a personal note, I'd rather use my glutathione for other biochemistry than to eat up ****ty OTC drug metabolites. That's a waste of good glutathione!
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