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  1. Labs/Situation Review & First Steps

    The most relevant marker on your labs as it pertains to your energy and motivation is your cortisol reading. Cortisol levels tend to peak about 30min after waking for most, if you are tolerant to caffeine then the likelihood it would really affect this is pretty minimal. I wrote this...

  2. The New Product Release Thread

    I will further add that although 5-LOX does not appear to interact with PGF2a production, it is important for the production of specialized pro-resolving mediators (SPMs) production. Other compounds shown to inhibit COX and LOX enzymes with a high degree of specificity and potency have been...

  3. Anyone supplement taurine daily?

    The study dosages vary a tad. One used 50mg per kg bw per day and two others used 6g per day. Id say 4g is better for the benefits I outlined as it its likely to at least meet the bw dosage used in one trial. Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed...

  4. Anyone supplement taurine daily?

    This is a good dosage to help with muscle recovery, taurine can prevent DNA damage to muscle cells by being cytoprotective. This results in less soreness and improved rates of recovery. It also helps with force output by balancing calcium signaling in muscle tissues while also helping protect...

  5. The New Product Release Thread

    I wrote this in another thread, copy and pasted relevant info here for you: (Note, ARA uses enzymes like COX and others to convert into active prostaglandins. PGF2a is the one we want from ARA use, we do not want PGE2 as this is why people get really sore and increased muscle damage.) Next I...

  6. Tell SNS What You Would Like to See From Us (2020 Edition)

    I like this idea.

  7. Can Anyone Explain Why Cues Like "F*ck Sh*t Up" Etc. Work Great?

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  8. So nobody has topical test??

    You too buddy, I post when I can.

  9. So nobody has topical test??

    It does not look like there is a negative feedback loop for exogenous DHEA to suppress internal DHEA/DHEA-S: Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed In theory, you would expect some DHEA/DHEA-S suppression from exogenous test/PH use, since the testes...

  10. Name your 2020 Favourite Supps in 4 Catergories

    Muscle Builder Creatine High nitrate vegetables throughout the day PreWorkout Coffee/Caffeine Spinach for nitrates Rhodiola Fat Burner/Fat Loss Coffee/Caffeine Wildcard (anything that doesn’t fit the 1st 3) Tart Cherry for recovery Possibly Curcumin for recovery Taurine for recovery...

  11. Sean's Powerlifting Journey

    I guess you can call it a rebirth. Hope all is well man.

  12. Sean's Powerlifting Journey

    Good to see your training is very alive and well.

  13. Negative Effect of Antioxidants around Workouts

    I left some stuff out, but this should give enough background one to understand many of nuances of this topic. If anyone has questions, I am happy to help further.

  14. Negative Effect of Antioxidants around Workouts

    References: Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid Link Removed Invalid...

  15. Negative Effect of Antioxidants around Workouts

    Supplementation and Use of Medications with Antioxidant and Anti-Inflammatory Effects The main area of debate regarding the pros and cons of these compounds in the conjunction with exercise and health is whether supplementation and the use of medications with antioxidant and anti-inflammatory...

  16. Negative Effect of Antioxidants around Workouts

    Muscle Damage Now that we have reviewed some key adaptive processes and concepts related to oxidative stress and inflammation and the benefits of these factors, it is important to discuss some downsides in more depth. Exercise-induced oxidation and inflammation can also lead to muscle damage...

  17. Negative Effect of Antioxidants around Workouts

    Ill leave you with some more as well: Cytokine Production Increased Nrf2 activity and mitochondrial ROS are densely connected to the adaptive process of muscular cytokine production. ROS can damage muscle tissues and lead to the production of inflammatory cytokines from muscle fibers...

  18. Negative Effect of Antioxidants around Workouts

    I agree with Resolve10's links and the information provided in them, I may be biased towards the second one though lol. In general, I wouldn't worry about things that predominately function through the upregulation of Nrf2 as opposed to directly blunting the production of reaction oxygen...

  19. Unanswered What is everyone's Thoughts On Turmeric ?

    Add on: Lastly, some lines of research indicate that curcumin can directly inhibit the activity of Nf-kB, a gene that regulates activity of COX-1 and COX-2 activity. We want these to be active so they can make PGF2a. However, the COX enzymes can be activated by more things then Nf-kB, such as...

  20. Unanswered What is everyone's Thoughts On Turmeric ?

    Please read the whole thread, this is something that has been debated in here in detail, my last post goes over this in some depth. But lets discuss this further then. Is it even inflammation that causes growth? The answer is, no, not strictly anyways. Cytokines are the what many refer to...
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