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  1. GoHardOrGoHme

    Clomid during cycle

    It improves fertility via acting at the testicular level and not the hypothalamus.
  2. GoHardOrGoHme

    Clomid during cycle

    HCG does not restart the HPTA
  3. GoHardOrGoHme

    Clomid during cycle

    Sorry by HCG should not be used willy nilly...anything whether it be SERMs, HCG, etc there is always cons and negative side effects. Weighing risk/benefit ratio is individualized. So sorry depending on the problem and the issues at play that statement is an oversimplification to the point of...
  4. GoHardOrGoHme

    Clomid during cycle

    That would be an interesting convo for a later time.
  5. GoHardOrGoHme

    Clomid during cycle

    Okay you need to clarify because depending on your pathway there are irreversible steps that are one way and these many time are your rate limiting steps. If you are talking about the majority of intermediary steps within a pathway okay, but rate limiting steps which prevent end products from...
  6. GoHardOrGoHme

    Clomid during cycle

    Clomid works wonder with that. But some individuals really struggle with emotional sides. Others need to regulate estrogen with an AI and SERM. Others need str8 HCG because the SERM route was too rough. A lot of factors. Glad you got a doctor to help, and I hope it was a good experience. With...
  7. GoHardOrGoHme

    Clomid during cycle

    Sounds good.
  8. GoHardOrGoHme

    Clomid during cycle

    site your source
  9. GoHardOrGoHme

    Clomid during cycle

    First: Okay if you want to argue different cells have different amounts of certain receptors we are in agreement. That clarification goes a long way. Second: When i was reading through the current argument that was the biggest miscommunication that I was noticing. Arguing affinity between...
  10. GoHardOrGoHme

    Clomid during cycle

    Invalid Link Removed Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and beta. Abstract Clomiphene citrate (CC) is known to possess dual actions as an estrogen agonist and an estrogen antagonist. To see how the dual actions of CC...
  11. GoHardOrGoHme

    Clomid during cycle

    a physiological antagonist is something that produces the opposite effect whether through transcription or signal release or etc. You are using one definition of antagonist, however you are wrong to separate reverse agonism from antagonism when talking about a physiological process.
  12. GoHardOrGoHme

    Clomid during cycle

    I cell type and a receptor type are GROSSLY different things. One cell can have MULTIPLE receptor types. I did not compare SERMS to estrogen, I compared SERMS to SERMS on its affinity to varying estrogen receptors. If you wanted to discuss affinity of SERMs VS Estrogens that is a separate...
  13. GoHardOrGoHme

    Clomid during cycle

    reverse agonist and antagonist are literally synonyms....Inverse agonist, reverse agonist, antagonist all mean to induce the opposit effect of the agonist. You literally defined a partial or mixed agonist/antagonist right after your corrected me. A SERM can shut off an estrogen...
  14. GoHardOrGoHme

    Clomid during cycle

    Allow me to clarify your statement. It is a poor SERM for breast tissue affinity.....it's a GREAT SERM for fertility. Remember..... these are Selective Estrogen Receptor Modulator. So some will select for different receptors and modulate them for different end goals.:biggthumpup:
  15. GoHardOrGoHme

    Clomid during cycle

    .......... so........ speaking of anatomy you know there are different kinds of estrogen receptors that depending on the SERM will have a different affinity to? So tamoxifen has a really strong binding affinity to breast tissue ER while clomid has much stronger activity in the hypothalamus with...
  16. GoHardOrGoHme

    Clomid during cycle

    Let me break down what Jinsun is saying.... If your engine is broke, not matter how much gas is in your tank the car won't run. What you are arguing for Ricky is when exogenous testosterone shuts down your pituitary, adding a stimulus such as clomid will keep it functioning. To use the same...
  17. GoHardOrGoHme

    Clomid during cycle

    do you by chance have the LH and FSH measurement? Or did you just do a total test measurement?
  18. GoHardOrGoHme

    Clomid during cycle

    Im skeptical because of the questions I posed, not because of it goes against everything I have learned. According to what I have learned, your experiment may be successful. Spurfy just elaborated why i think this is plausible, what I want to see is whether it actually occurs. The plausibility...
  19. GoHardOrGoHme

    Clomid during cycle

    Honestly, this is something I have been wondering myself and offered my input because theoretically I think its plausible given the MOA of clomid. However, the hole in your argument is the following: 1) question of whether or not primo will show up as elevated test regardless of LH and FSH 2)...
  20. GoHardOrGoHme

    Clomid during cycle

    primobolan depot has a half life of 10 days. So to clarify, the primo may show up as test during a routine total test blood work. This is what I am skeptical about. Now my assumption can be completely incorrect and primo wont show up as test on a standard hormone panel, but in the case that it...
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