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  1. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    At the same time, GABA isnt mainly being excreted. It is working in other areas to upregulate serotonin. If the majority is being directly excreted it isnt acting anywhere else. Like I said way in the beginning. We have no mechanism why it should or does work in humans. We know it isnt...
  2. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Think of the limiting factor for its skeletal muscle absorption as its direct route to excretion.
  3. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Now find where it is shown to enter muscle tissue. Hint: it isn't. Having some similar metabolites from liver metabolism isn't all that telling. I even posted a study above showing that main metabolite, the problem is it is vast majority being excreted.
  4. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    You are correct. That doesnt disagree with what I said. Large portions are not metabolized. But some are. It is not completely metabolized, but there is some happening. Thats why you see both metabolites and full ecdy in excretion. Invalid Link Removed
  5. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Yes
  6. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Thats not the case in this instance. Ingesting ecdy orally (shown by radioactive labeling in humans) shows that it is ingested in the ileum picked up by the liver and then ejected in bile acids, and then quantitatively excreted via urine/feces. Ecdy is too water soluble to be able to...
  7. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    That wouldnt follow without creating a new type of carrier for the ecdy itself. That has not currently happened.
  8. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Oral availability is terrible for ecdy. Taking it on an empty stomach won't change the fact that it is massively water soluble and uptake into human cells is a very real challenge.
  9. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Nah, you weren’t insinuating that. The study at hand suggests gains on that scale, which is why Im skeptical. I’m not saying it can’t work. I think it probably doesn’t, BUT with the new research it would be foolish to outright dismiss it without some follow-up studies. I think if it does...
  10. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    Ive used Iron Forged. Never noticed anything personally, if it was AAS style gains as suggested by that study this would be impossible. Lax and ecdy are called a scam at this point in time because it doesnt seem to work in most people. And there is no likely mechanism (yet?). It’s possible...
  11. Powercage

    Unanswered Ecdysterone-Anabolic effect of ecdysterone strong enough to put it on the doping list

    To be fair, they tested the participants in the recent study for AAS. Im not sure what method for testing they used off-hand. Now realistically, people that want ecdy to succeed are treating this like the Jacob Wilson study on HMB, which we found out later was impossible to replicate...
  12. Powercage

    Citrulline + pycnogenol , erections and breathing

    You dont need to breathe when you have huge erections.
  13. Powercage

    Unanswered ecdysterone any experience ?

    I didnt miss them. I dont put stock in anecdote. There are a lot of reasons you could believe something works. I think it’s irresponsible to promote something with so many issues and so little research backing. That may change in the future if better research is presented. This is the...
  14. Powercage

    Answered best laxogenin product to date ?

    Laxo is meh
  15. Powercage

    Unanswered Shockingly Low T (Help!?)

    Dont see an endo, see a urologist. Endos tend to be very poor for TRT.
  16. Powercage

    Unanswered ecdysterone any experience ?

    I wouldn't spend money on ecdy yet personally. Like I said, I am not convinced by the current research (and having tried numerous products myself I saw nothing, although that is n=1, so you should take that with a grain of salt). There are other studies that have been done in humans where it...
  17. Powercage

    Unanswered Yohmbine question?

    Every yohimbine HCl product is technically illegal in the US. I believe alpha Yoh is as well, but do not quote me on that.
  18. Powercage

    Unanswered Yohmbine question?

    No food in your system whatsoever. Essentially avoid anything that causes an insulin spike as insulin inactivates yohimbine HCl. Also, technically, yohimbine HCl is a controlled substance that shouldn't be available OTC yet is for some reason :p
  19. Powercage

    Unanswered Joint Supps

    Yea that's why you don't see a ton of companies pushing it. It is a patented ingredient.
  20. Powercage

    Unanswered Joint Supps

    lol, Im sorry man. I ruin dreams sometimes, but it's usually while trying to help you. 150mg daily should do the trick. There is some research showing smaller doses taken for prolonged periods of time may be effective, but I am more convinced by the 150mg daily at this time. Taken with...
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