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  1. AMNES1A Q&A

    Did some deep digging. You sir are correct!!! Now, aside from 2D6 variance, I have seen far more people complain of benadryl keeping them foggy than doxylamine. Perhaps Benadryl has an active metabolite that last far longer.

  2. AMNES1A Q&A

    Not really, they’re about the same. But diphenhydramine seems to be more susceptible to genetetic polymorphism in p450’s. Especially with 2D6. That’s why the half life ranges is so wild, from 2hr to 18hr. I haven’t seen as many people complain of doxylamien making them groggy.

  3. AMNES1A Q&A

    That’s why I like doxylamine over Benadryl. Clears the system faster, so less grogginess. Makes you cinstipsted if you take it a lot though.

  4. AMNES1A Q&A

    Try a quarter of a doxylamine and cut stims and coffee. Could be stress too; don’t go for ambien. It looses effects after two weeks man.

  5. AMNES1A Q&A

    Hey, bupropion works through dopamine and norepi reuptake inhibition. Human receptor binding shows 5-HT receptor inhibition at around 2%. So 5-HT supplements are not likely to be a big deal. Now, this stuff has a lot of herbal products in it which are very difficult to find receptor binding...

  6. Injectable replacement for tren during a strength cycle

    Okay not mocking you, seriously asking, but are you autistic? Or dyslexic? Genuinely asking. It would seem either you are not understanding me or I am not conveying my points well. And I’ve been in college 8 years, I have two chem degrees and almost done with doctorate with a research focus in...

  7. Injectable replacement for tren during a strength cycle

    Same, I don't care. I get no money from anything. Put it to bed, I was having fun with Frymaster! He gets awful sore idk why. Thank you for representing your thoughts with good sources, even if we reach different conclusions. Few rarely take the time to read the nit picky details on things.

  8. Injectable replacement for tren during a strength cycle

    Read this one, Invalid Link Removed "Collectively, these data support the notion that the C19-angular methyl group, which is the site of attack for the first and second hydroxylation reactions [4,6], is important for optimal formation of aromatic A-ring products by the human P450 aromatase...

  9. Injectable replacement for tren during a strength cycle

    Who said I don't understand aromatization? Only you did. The scope of this conversation is limited to the biochemical pathway via the aromatase enzyme, as it accounts for any significant amount of estradiol produced. Other cyp mediated production has shown to be so insignificant its not...

  10. Injectable replacement for tren during a strength cycle

    Finish reading. They do not interact with aromatase. I suggest you review your chapters on keto-enol tautomerization; this is what happens.

  11. Injectable replacement for tren during a strength cycle

    Correct. So AI is worthless, SERM is needed. This was the entire point

  12. Injectable replacement for tren during a strength cycle

    Well, it would look like I have more experience than you in chemical synthesis. Who is Jbry? This is old and I don't have enough time to go through 9 pages of crap, since I just got done giving an hour long presentation on Oxandrolone in burn patients to some faculty and colleagues...

  13. Liver damage from oral AAS greatly exggerated

    I get this from several compounds. AR agonists with an altered nucleus decrease the innate immune response but increase the humoral response. Estrogens do the opposite from what I've read.

  14. Liver damage from oral AAS greatly exggerated

    I have to present a poster on this very topic tomorrow. Well, actually it's an unexpected secondary anti-inflammatory outcome.

  15. Liver damage from oral AAS greatly exggerated

    Just saw this, think I can explain a possible explanation. You have this thing called residence time for renally excreted drugs. After it’s secreted into the urine before it’s actually urinated out you can decrease the time a drug resides in the filtrate by administering diuretics, pH adjusting...

  16. Liver damage from oral AAS greatly exggerated

    Precisely; aside from the unchanged drug Being 1/3 i can’t seem to find much pharmacokinetics either. What I’m kooking for is specific metabolites defected. So if you find it let me know!

  17. Liver damage from oral AAS greatly exggerated

    I was just calculating some stuff from the oxandrolone study. Some NNT and NNH, but no ADR's reported so no NNH. Also, I know there is no cyp metabolism on first pass, second pass im not sure, but some odd blood esterase blood activity on the lactone. It appears to be excreted as about 1/3...

  18. Liver damage from oral AAS greatly exggerated

    Whatt??? I thought it was p450 inhibition???? Caffeine free's adenosine up for cAMP/ATP, i get that, but as far as I read it was just p450 inhibition by caffeine that increases oxandrolones serum levels.

  19. Liver damage from oral AAS greatly exggerated

    HGH makes the organs and bones grow drastically more than the muscles.

  20. Liver damage from oral AAS greatly exggerated

    Well he actually went into V. Tach. He was known to abuse cocaine and he had admitted himself on his youtube videos that he had an adderall problem. So adderall problem plus that white powder the police allegedly found (probably cocaine) coupled with his athletically enlarged heart, and his...
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