Recent content by radone
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Myostatin Sequence?
Just curious as to why you would want myostatin's sequence? You don't want to increase it, as it will decrease your muscle mass. Of course if you are thinking of making an inhibitory peptide fragment, that would be a good idea. Also soluble myostatin receptors are effective for inhibiting... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
Superchip, Take a look at IGF gene therapy studies done by Dr. Lee Sweeney. The idea is that direct intramuscular injection would lead to increased IGF only in the muscle. So, the other risk associated with IGF should be reduced. These are only animal studies, so who knows how the results... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
xxl610, There is some info on genetherapy dot net. If you google follistatin or myostatin inhibitors there is also some good info. -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
xxl610, There is some info on genetherapy dot net. If you google follistatin or myostatin inhibitors there is also some good info. -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
Angelo, I don't think I would try it. That type of drug tends to have a lot of sides. Now acvr2b, that would be worth trying. -
Myostatin Sequence?
I think they may have on Openbiosystems website. Also you may find it on Origene. -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
It is very expensive. There may be some options for custom bulk synthesis. That may get the prices down to a reasonable level. Also, I forgot to mention that was once a week dosing at 10-50mg/kg. I did see some research that suggest that dosing might be effective for every 3-4 weeks. That... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
JohnnieFreeze, You are probably right. Researchers are losing interest for that one. I have checked around on research grade acvr2b. It seems like a better choice. It is just too high for a researcher in today's economy. I will keep an eye out for a better deal. -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
I have heard about myo-029. It is a monoclonal antibody blocking the myostatin receptor. That helps block the effect of myostatin. The trials weren't super exciting. The company that was developing it has decided not to move any further with it. This doesn't mean that it would not work for... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
Darkvard, I don't think they are. But I am sure that once there is a little more data or when the agents are more available, then it will be used for performance enhancement. The researchers are predicting that it will be showing up in athletes within the next 2 years. There is no way to... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
Bigironkiller, I am glad you asked. That is my speciality. I do minimally invasive imaged guided spine procedures. You should research ozone disc therapy. It is used more in Europe, though you can find it in the US. It has good success, better than surgery for an isolated disc... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
Darkvard, There are several types of gene therapy vectors. Adenoviruses are fairly safe. There is a gene therapy for treating cancer (gendacine) approved in China using adenoviruses. Adeno associated virus (AAV) are probably the one of choice. There is a low immune response with good gene... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
My initial post was really meant to see if anyone is getting good results injecting IGF-1. The gene therapy for IGF-1 in animals was very impressive. It seems that you should be able to obtain similar results with peptide injections. Plus with peptide injections, you control the amount... -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
I agree that it isn't cheap. However, a single injection can give 2 plus years of muscle 2-4x greater than steroids. If you compare it, in the long run, gene therapy is a better value. -
Follistatin, ACTN3, IGF-1, shRNA myostain and gene therapy
Undergraduate was biochemistry. I have an MD, but also post graduate work in Molecular Biology and Biochem. My research has been mainly for cancer gene therapy, but got into anabolic work for cancer muscle wasting. Once I started working on muscle building, I have become completely consumed...