HIT4ME's latest activity

  • HIT4ME
    HIT4ME replied to the thread AMPK Inhibitors.
    I didn't imply there is a "need" to convert glucose to fat - that's the point. Your body is VERY good at preserving itself, and we have evolved to have mechanisms which conserve mass in times of...
  • HIT4ME
    HIT4ME replied to the thread AMPK Inhibitors.
    Ok, your responses deserve and require much more time than I have to a lot today, but to discuss what I can. To be clear I am stretching here and just appreciate the discussion and I am not saying...
  • HIT4ME
    HIT4ME replied to the thread AMPK Inhibitors.
    @nostrum420 - great stuff...will be reading through jt.
  • HIT4ME
    HIT4ME reacted to nostrum420's post in the thread AMPK Inhibitors with Like Like.
    As for the relatively high concentrations of AMPK in the brains of Alzheimer's patients, "In Alzheimer’s disease, creatine kinase activity is reduced by as much as 86% along with a reduction of in...
  • HIT4ME
    HIT4ME reacted to nostrum420's post in the thread AMPK Inhibitors with Like Like.
    "There's no real need to create glucose from fat. Your body can create an incredible amount of ATP from fat already. Even if your body is lacking in blood glucose, it can break down muscle and...
  • HIT4ME
    HIT4ME reacted to nostrum420's post in the thread AMPK Inhibitors with Like Like.
    The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways...
  • HIT4ME
    HIT4ME replied to the thread AMPK Inhibitors.
    Me too. :)
  • HIT4ME
    HIT4ME replied to the thread AMPK Inhibitors.
    Great questions - of course this is a theory and the validity of any idea is based on the experiment. I've tried to find studies showing elevated or depleted levels of AMPK in the obese and have...
  • HIT4ME
    HIT4ME reacted to Whisky's post in the thread AMPK Inhibitors with Like Like.
    I guess my main question here is what is the rationale behind looking into this? if it’s genuinely to explore the way the human body works and make advances in our understanding of these...
  • HIT4ME
    HIT4ME reacted to nostrum420's post in the thread AMPK Inhibitors with Like Like.
    Questions that spring to mind: Why don't study models where AMPK is elevated show resulting weight/fat gain? Why does it tend to be the opposite? If an organism is not "burning" (metabolizing)...
  • HIT4ME
    HIT4ME replied to the thread AMPK Inhibitors.
    Ok, so - I hate to lay out all my theories where someone can take my ideas and either open myself up to criticism or have anything that may be beneficial taken and used for profit....but...there...
  • HIT4ME
    HIT4ME reacted to Whisky's post in the thread AMPK Inhibitors with Like Like.
    I see a lot on activating it in the longevity space where I read a lot. Issue for us is that AMPK and Mtor are directly opposed when it comes to muscle building goals. Most people I follow who...
  • HIT4ME
    HIT4ME reacted to Rocket3015's post in the thread AMPK Inhibitors with Like Like.
    Could this catabolism cause great fat catabolism? This is what I need !!
  • HIT4ME
    HIT4ME reacted to Iwilleattuna's post in the thread AMPK Inhibitors with Like Like.
    Well, it has been shown to increase glucose uptake into cells , so I see where you’re going with this . Maybe it’s a response to possibly prevent catabolism from ampk increase productivity...
  • HIT4ME
    HIT4ME reacted to Iwilleattuna's post in the thread AMPK Inhibitors with Like Like.
    phosphocreatine? Would this just be standard creatine in general? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132561/ “ AMPK is also allosterically inhibited by physiological concentrations of...
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