I wonder if some of those results are due to "contamination" (accidental, or otherwise) with an oral DS/PH. Hard to imagine why this would suppress T otherwise.
The ≈20% of subjects requiring a dose increase after 2 years could quite easily be explained by subjects' vascular function continuing to decline. Target market is old guys, after all.
The non-responders may also have such ****ty endothelial function that no amount of cGMP can compensate for...
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