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Anxiety and how to help calm it

GreenMachineX said:
So far I can tell Ceretropic's makes me feel more connected to everything and everyone, increases mood dramatically (borders euphoria), and kills social phobia. SDFT's decreases anxiety and social phobia but doesn't increase the desire to socialize, whereas this does. And SDFT's makes me feel disconnected from everything at anything higher than 15mg.
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This sounds more like it man. Sounds like Ceretropic has proper tianeptine
 
GreenMachineX said:
So far I can tell Ceretropic's makes me feel more connected to everything and everyone, increases mood dramatically (borders euphoria), and kills social phobia. SDFT's decreases anxiety and social phobia but doesn't increase the desire to socialize, whereas this does. And SDFT's makes me feel disconnected from everything at anything higher than 15mg.
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Are you using their sulfate powder or sodium powder tianeptine? Ceretropics sell both plus they have a liquid solution also.
 
GreenMachineX said:
So far I can tell Ceretropic's makes me feel more connected to everything and everyone, increases mood dramatically (borders euphoria), and kills social phobia. SDFT's decreases anxiety and social phobia but doesn't increase the desire to socialize, whereas this does. And SDFT's makes me feel disconnected from everything at anything higher than 15mg.
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That sounds incredible. Now I "need to" try it. lol

1) Does Ceretropic make a liquid suspension or capped preparation.....or only powder?

2) Do I want the sodium or sulfate version? Sulfate correct?

Thanks
 
Have you guys heard of or tried this stuff from Ceretropic?

Bromantane (Ladasten) was developed in Russia in the late 1980's. It is a stimulant, but is unique in that it also has anxiolytic properties. Bromantane mainly inhibits the reuptake of dopamine and serotonin in the brain. Research has shown it is effective in treating asthenic disorders, and was prohibited by the IOC for its stimulant properties. It has also been shown to boost the immune system.
 
ELROCK said:
Are you using their sulfate powder or sodium powder tianeptine? Ceretropics sell both plus they have a liquid solution also.
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I'm using the sodium powder, but the sulfate powder looked interesting also.

Whacked said:
That sounds incredible. Now I "need to" try it. lol

1) Does Ceretropic make a liquid suspension or capped preparation.....or only powder?

2) Do I want the sodium or sulfate version? Sulfate correct?

Thanks
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1. Yes, they have a liquid solution but no caps.
2. Not sure; they claim the sulfate form is longer acting. I'll probably be trying that when it's back in stock.
Whacked said:
Have you guys heard of or tried this stuff from Ceretropic?

Bromantane (Ladasten) was developed in Russia in the late 1980's. It is a stimulant, but is unique in that it also has anxiolytic properties. Bromantane mainly inhibits the reuptake of dopamine and serotonin in the brain. Research has shown it is effective in treating asthenic disorders, and was prohibited by the IOC for its stimulant properties. It has also been shown to boost the immune system.
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Yeah, it looks interesting for sure. Not sure if I'll be trying it though.
 
Thanks Green
 
Whacked said:
Thanks Green
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Beware though. Apparently I was taking a little too much yesterday ( no scale, just using a smidgeon scoop [1/32 tsp]), and I woke up this morning with a killer headache. I used half a smidgeon scoop this morning which should be about 30mg according to how I figured it out. 1/8th tsp is about 240mg, divided by 4 to get the smidgeon amount, then half that. Anyone have a smidgeon scoop and scale they could confirm this for me?
 
Thanks man

PS: anyone concerned Tia's hepatotoxicity profile (from regular use)
 
This is the first I've ever heard about hepatoxicity and I've been doing research on it for years.

There was a case study where someone ingested a ridiculous amount in order to try illicit a high, might've been 50 tabs or so. Didn't cause damage. I'll see if I can find the study on toxicity, but yes it's supposedly nontoxic.
 
I don't know fellas. I read a few diff sites and feedback and it seems there is a concern albeit mild but using this consistently (several times daily) then cumulatively I speculate potential for liver stress. How much will vary of course.
 
Would love to see any studies (actual studies and not speculation)! I've read some myself concerning this and will locate & post
 
Same here and while you are correct that the PubMed studies (the ones I have read) considered a significant liver stress from Tia a rare event; I don't recall the studies taking into account regular use / long term.
 
GreenMachineX said:
Beware though. Apparently I was taking a little too much yesterday ( no scale, just using a smidgeon scoop [1/32 tsp]), and I woke up this morning with a killer headache. I used half a smidgeon scoop this morning which should be about 30mg according to how I figured it out. 1/8th tsp is about 240mg, divided by 4 to get the smidgeon amount, then half that. Anyone have a smidgeon scoop and scale they could confirm this for me?
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What is your dosing regimen? How much and how often?
 
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Tianeptine--an instance of drug-induced hepatotoxicity predicted by prospective experimental studies.
Le Bricquir Y, et al. J Hepatol. 1994.
Show full citation
Abstract
We report the case of a patient who developed acute hepatitis after taking tianeptine, a new tricyclic antidepressant, for 8 weeks. Hepatitis exhibited cholangitis-like clinical features and was associated with hypersensitivity manifestations suggestive of an immuno-allergic mechanism. Histological examination showed microvesicular steatosis. The discontinuation of tianeptine administration was followed by complete recovery. Immunoallergic hepatitis and microvesicular steatosis were predicted 2 years ago from prospective experimental studies prompted by the similarity of the chemical structures of tianeptine and amineptine, another tricyclic antidepressant, well-known for its hepatotoxicity. Experimentally, tianeptine has been found to be oxidized into reactive metabolites in several rodents and human liver and to produce microvesicular steatosis probably through inhibition of mitochondrial beta-oxidation of fatty acid in mice. This case illustrates the value of prospectively assessing potential hepatotoxicity mechanisms for new compounds chemically related to drugs already known to be hepatotoxic.
 
Conjecture from another site.


Hi, I have been doing more research on Stablon (tianeptine), a modified tricyclic antidepressant useful in treating depression and various anxio-depressive states.

Information is hard to come across when it involves medications which are neither FDA-approved nor used in the United States.

Stablon has shown promise in treating not only depression, but also bronchial asthma according to pulmonology specialist Dr. Lechin, M.D. and associates who have done numerous studies on it recently.

Stablon has also been shown to block panic attacks as well as Paxil (paroxetine) when panic disorder patients were exposed to 35% CO2 (carbon dioxide) gas.

The problem is that after doing more research, I have found that Stablon (tianeptine) is closely related to Survector (amineptine), which is known and demonstrated to be toxic to the liver (hepatotoxic). This led to Survector's manufacturer to stop marketing the drug and now it is hard to find.

Stablon was thought to be quite safe, but it too is metabolised in the same way as Survector... broken down into reactive metabolites in the liver. This in turn, in susceptible individuals, can cause death to lymphocytes and liver cells (hepatocellular damage), resulting in hepatitis, cholangitis and necrosis. Often a rash precedes the hepatotoxicity and abrupt discontinuation results in quick recovery.

If anyone else here is taking, or considering to take, Stablon or Survector, please note the following information contained in the abstract below. This is one of many abstracts which demonstrate hepatotoxicity. Those considering taking these drugs should have frequent LFTs (liver function tests) to be on the safer side.
 
Ahh yes, if it's a rare event, I don't concern myself too much with it. I guess the important thing is to know what to look for.

I usually take it for 3 month periods, for years now (since 2008). Never had a problem and liver enzymes always tested fine. I guess I'm a typical case study then.
 
A single individual getting hepatitis is hardly worth mentioning, in my opinion. If this were actually an issue, I'd think there would be a lot more information and anecdotal evidence out there.
 
Whacked said:
What is your dosing regimen? How much and how often?
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With SDFT's 12mg every 3 hours. With Ceretropic's, 20-30mg 3 times a day is the plan, but I just started it yesterday so not sure how it's gonna go. I also definitely took too much yesterday so I'm hoping I didn't already start tolerance issues.
Gutterpump said:
The study I'm looking for is one that shows it's also virtually impossible to overdose on tianeptine
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That's what I've read. The only thing I've seen regarding liver toxicity was a case of a man overdosing tia in combination with alcohol.
 
Ha! Awesome.

I took 30 mg Tia 2 hours ago and didn't notice jack. Lol.
 
Nope. First time. I got it from powder city
 
Whacked said:
Nope. First time. I got it from powder city
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Gotcha. I've seen a lot of reports of first and second time uses without effects. My suggestion would be to take the next several regularly scheduled doses and eventually it'll kick in. Don't do what I did yesterday and keep taking it every half hour in larger amounts until you feel it lol
 
GreenMachineX said:
Gotcha. I've seen a lot of reports of first and second time uses without effects. My suggestion would be to take the next several regularly scheduled doses and eventually it'll kick in. Don't do what I did yesterday and keep taking it every half hour in larger amounts until you feel it lol
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lol. I will leaned from your mistake for sure. lol :p ;)
 
........
 
Gutterpump said:
Ahh yes, if it's a rare event, I don't concern myself too much with it. I guess the important thing is to know what to look for.

I usually take it for 3 month periods, for years now (since 2008). Never had a problem and liver enzymes always tested fine. I guess I'm a typical case study then.
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Do you notice when taking tianeptine that some effects get better with time, or just that the acute effects wear off? In other words, with continued dosing of 30mg TID, will I notice more effects with time or is this all it is?
 
GreenMachineX said:
Do you notice when taking tianeptine that some effects get better with time, or just that the acute effects wear off? In other words, with continued dosing of 30mg TID, will I notice more effects with time or is this all it is?
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I think it depends on the user and what it's being taken for. If it's for state of mind / depression, etc, yes it gets better with prolonged use. It is, after all, an anti-depressant with anxiolytic properties. It was manufactured first and foremost for major depression.
 
Anyone ever try Sulbutiamine? Supposed to be good for depression, mood enhancement and social anxiety
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Whacked said:
Anyone ever try Sulbutiamine? Supposed to be good for depression, mood enhancement and social anxiety
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I've only tried it in Molecular Nutrition's Accelerant which is probably just a little underdosed. Some of what I just read on your link sounds interesting though, particularly curbing behavior inhibitions. Perhaps I'll give it a whirl on its own.

I've emailed Ceretropic's regarding tianeptine sulfate; they said it would be back in stock in a couple weeks. So I'll be trying that as soon as it's in. Working with this tianeptine sodium powder and its short half life is not something I'm willing to continue long term.
 
Whacked said:
Anyone ever try Sulbutiamine? Supposed to be good for depression, mood enhancement and social anxiety
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Sulbutiamin is in Choas & pain's Genius product, but it is severely underdosed. It looks interesting enough to give it a solo run.
 
I love sulbutiamine. I use it often.

In some ways it's subtle as you don't feel the kind of energy you get from caffeine or other stimulants, but in other ways you can definitely tell it's there. Very clean.
 
I'm also testing out Ceretropic's rhodiola, and the first couple days I experienced a strong motivational type of energy but that seems to have disappeared. I've read some reviews around the net and from what I gather, rhodiola's effects can have a dopaminergic or serotoninergic (sp?) edge to it depending on the rosavins and salidrosides/tyrosol content, and only a few companies have the effects with a stronger leaning towards dopamine. Eclectic was supposed to have that effect as well but it's oos everywhere, so I'm going to keep looking to see whose else could have what I'm looking for.
 
For those that were interested, Ceretropic has tianeptine sulfate back in stock for a better price. This is supposedly the long acting version. I ordered 10g. Tianeptine is by far my favorite brain supplement.
 
GreenMachineX said:
I'm also testing out Ceretropic's rhodiola, and the first couple days I experienced a strong motivational type of energy but that seems to have disappeared. I've read some reviews around the net and from what I gather, rhodiola's effects can have a dopaminergic or serotoninergic (sp?) edge to it depending on the rosavins and salidrosides/tyrosol content, and only a few companies have the effects with a stronger leaning towards dopamine. Eclectic was supposed to have that effect as well but it's oos everywhere, so I'm going to keep looking to see whose else could have what I'm looking for.
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Bulk Supplements has the 3% salidrosides if you are looking for the dopamine.
 
Yep, it is quite different than 3% rosavins. This is very energetic mentally and can make you a little spacey because your mind is going so fast. I think it was fine for nice clean energy, but the mental aspects were counterproductive for me. I prefer green tea for my energy or 3% rosavin for a balance.
 
kisaj said:
Yep, it is quite different than 3% rosavins. This is very energetic mentally and can make you a little spacey because your mind is going so fast. I think it was fine for nice clean energy, but the mental aspects were counterproductive for me. I prefer green tea for my energy or 3% rosavin for a balance.
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That's what I'm looking for I think. I love what tianeptine is doing for me, but I'm going to want something to switch to when it "stops working" like I've read so much about. My job is high demand/high stress constantly and I'm trying to find something that balances energy/motivation with stress/anxiety. I stopped taking regular rhodiola for a while, but tried it again this morning and brain fog ensued. So, no more of that. Sticking with Ceretropic's until I test out bulk supplements'.
 
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