MidwestBeast in: The Case of the Mysterious Weight Gain! - AnabolicMinds.com - Page 4

MidwestBeast in: The Case of the Mysterious Weight Gain!

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    Quote Originally Posted by ssbackwards View Post
    http://diabetes.diabetesjournals.org...46/4/717.short

    http://diabetes.diabetesjournals.org...3/5/1253.short

    http://ajpendo.physiology.org/content/283/1/E187.full

    http://www.sciencedirect.com/science...31938406002447

    now im looking into another satiety hormone like GLP1 and PYY, im not sure there can be a resistance to this, however it can be high post prandually which can cause that satiety. need to research it more in regards to leptin resistance. However im really thinking your leptin issues are the main cause for throwing off other hormones in your body and the way the normal signaling works.

    I cant find a good study, but its something to look into.
    I'll take a look at these this evening. I appreciate you taking the time to post stuff like this; it really means a lot (this pretty much consumes my life at the moment).






    So something else to note. This has happened a bit for the past couple months, but I'm really noticing it, today (and it could just be getting used to my keyboard again after using my work keyboard -- Macbook vs. Dell). I am transposing a lot of letters when I'm typing. It's not making spelling mistakes; it's actually switching out the order of letters in the middle of words (I've caught it and fixed it in several posts, today, already). I notice it instantly (largely just due to the red underlining, I imagine), but it's not like I do it and then go back and then realize it.

    Still, though, it's a bit odd for me.
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    All right, so I met with my GP, this morning, again.

    This meeting just really solidified why I like working with him. I didn't have the best grasp on thyroid antibodies and how a problem with them (like Hashimoto's) could be an issue if you were already treating with exogenous thyroid hormone. He actually drew out a diagram and explained it to me. Finding a doctor who A) knows his stuff B) knows how to explain it C) has a good rapport with you and D) appreciates the researching that you put in is hard to find. Once you do, you don't leave that.

    Anyway, it was a great meeting (we talked for probably half an hour) and on Friday morning I'm having thyroid antibodies checked for the first time (even though I'd requested this back in June with my 1st endo and they never did), a heavy metal screening (he said that serum levels outweigh urine testing because with urine it's hit and miss as it could just be leaving your body and not actually staying in there), checking insulin and doing a glucose tolerance test. I'm very hopeful that of these 4 (arguably, 3) things, I will find some resolution. If not, I've still got plenty to look at!
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    Sounds like hit a good doc!!!
    Looking forward to seeing what the tests show!!
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    Quote Originally Posted by mattrag View Post
    Sounds like hit a good doc!!!
    Looking forward to seeing what the tests show!!
    Yeah, man. He's the doc that prescribed my the Cytomel and actually listened about the importance of keeping rT3 down.

    The insulin intrigues me because my dad is diabetic and has to take insulin throughout the day. I stopped eating carbs for the most part for several years until I moved and my friend turned me onto Anabolic Pump. I used some form of insulin mimetic or GDA before EVERY carb-heavy meal (honestly, more than 30g or so) for a year and a half. I stopped the use of them around May when I cut out all supplements to try and get a better judgment on what was causing the problems. Things degraded much more rapidly from June-now.

    My weight doesn't really drastically jump up. But it will climb, and not fall (outside of water weight). Insulin problems would logically (in my opinion) explain nutrients being shuttled predominantly to fat and hindering weight loss.

    However, the fact that I took 100mcg of T3 daily for 10 weeks and didn't lose any weight (or strength) still doesn't sit well with me (making me think thyroid antibody issues).

    And the absolute inability to lose weight (not just having to starve myself and train like a mad man to lose) started ~4 months after I had been living in KY. That's what makes me wonder about the heavy metals. If the pipes around here are that bad, since I drink about 2 gallons of water/day, it would make sense.

    So, we'll see. Friday will be the testing and hopefully before Christmas I'll get a call from the doc to tell me what's up.
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    That'd be a great Xmas present.

    Figuring out what is wrong and getting on path to fix it.
    Hope it all turns out well for you.
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    Quote Originally Posted by MidwestBeast View Post
    All right, so I met with my GP, this morning, again.

    This meeting just really solidified why I like working with him. I didn't have the best grasp on thyroid antibodies and how a problem with them (like Hashimoto's) could be an issue if you were already treating with exogenous thyroid hormone. He actually drew out a diagram and explained it to me. Finding a doctor who A) knows his stuff B) knows how to explain it C) has a good rapport with you and D) appreciates the researching that you put in is hard to find. Once you do, you don't leave that.

    Anyway, it was a great meeting (we talked for probably half an hour) and on Friday morning I'm having thyroid antibodies checked for the first time (even though I'd requested this back in June with my 1st endo and they never did), a heavy metal screening (he said that serum levels outweigh urine testing because with urine it's hit and miss as it could just be leaving your body and not actually staying in there), checking insulin and doing a glucose tolerance test. I'm very hopeful that of these 4 (arguably, 3) things, I will find some resolution. If not, I've still got plenty to look at!

    Holy smokes and to think i asked about this way back in the beginning. Let's hope you finally get an answer you have been searching for.
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    Yep, I'd be a very happy man to find that out. I was 274.8 lbs at my weigh-in this afternoon (in dress slacks, a polo, dress shoes and with my keys/phone on), so I've got about 75 lbs I'm looking to shred off. Whenever I figure it out you can believe I'll be starting an epic log and going into fitness model mode, haha.
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    Makes me wonder if I have hypo thyroid.... Let's see I gain fat very easily and it is difficult to take off although nothing like your experience if I want to shred I do..... Maybe just a slow metabolism?
    Test e/dbol/epi/winnie
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    Quote Originally Posted by schwellington View Post
    Makes me wonder if I have hypo thyroid.... Let's see I gain fat very easily and it is difficult to take off although nothing like your experience if I want to shred I do..... Maybe just a slow metabolism?
    Well, in essence, thyroid = metabolism (I'm well aware that's not a completely true statement, but for these purposes, it illustrates the point). I always thought, "I must have a slow metabolism," too. What I didn't know, was that even though your metabolism is unique to you, you can still control it to an extent. Certainly more plays into it than just the thyroid, but it's worth getting a thyroid panel done if you never have, before.

    I kick myself for not doing that back in high school or college, but back then, I just thought I wasn't working hard enough or eating well enough. In retrospect, barely eating, lifting and playing basketball for 3 hours a night should have had me tiny lol, so all the signs were there.
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    Quote Originally Posted by MidwestBeast View Post
    Well, in essence, thyroid = metabolism (I'm well aware that's not a completely true statement, but for these purposes, it illustrates the point). I always thought, "I must have a slow metabolism," too. What I didn't know, was that even though your metabolism is unique to you, you can still control it to an extent. Certainly more plays into it than just the thyroid, but it's worth getting a thyroid panel done if you never have, before.

    I kick myself for not doing that back in high school or college, but back then, I just thought I wasn't working hard enough or eating well enough. In retrospect, barely eating, lifting and playing basketball for 3 hours a night should have had me tiny lol, so all the signs were there.
    I used to play tennis for 6 hrs a day, drink 2 shakes, a jamba juice and then lift and sleep... I still was over 220... haha. Yea... I always said it was because I was dieting for 8 years... Perhaps Ill get that done too when I go back to Hawaii in Feb. Along with my test panel as well.
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    Quote Originally Posted by mattrag View Post
    I used to play tennis for 6 hrs a day, drink 2 shakes, a jamba juice and then lift and sleep... I still was over 220... haha. Yea... I always said it was because I was dieting for 8 years... Perhaps Ill get that done too when I go back to Hawaii in Feb. Along with my test panel as well.
    I advise it to everyone. I'm doing annual blood work from now on, anyway, on all the important stuff (and of course whatever this problem ends up being will be checked more regularly). When I was younger, I didn't have the knowledge of how over-dieting could screw your metabolism up and make it worse. The weirdest thing about all of this is once I actually studied nutrition at it's basic levels and got really smart about what I was doing, I had a couple months of great success and then that's when I hit my plateau. I was in worse shape when I was smarter and doing things better! lol

    But yeah, I'm a huge advocate for blood work. You get stuff right in the gym and the kitchen, first, but you don't waste years or even months before searching for another cause/issue as long as you rule out the diet and training, first.
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    Quote Originally Posted by MidwestBeast View Post
    I advise it to everyone. I'm doing annual blood work from now on, anyway, on all the important stuff (and of course whatever this problem ends up being will be checked more regularly). When I was younger, I didn't have the knowledge of how over-dieting could screw your metabolism up and make it worse. The weirdest thing about all of this is once I actually studied nutrition at it's basic levels and got really smart about what I was doing, I had a couple months of great success and then that's when I hit my plateau. I was in worse shape when I was smarter and doing things better! lol

    But yeah, I'm a huge advocate for blood work. You get stuff right in the gym and the kitchen, first, but you don't waste years or even months before searching for another cause/issue as long as you rule out the diet and training, first.
    Let us hope till that time comes I can use my wonderful PH to help me look decent haha. Probably not... but oh wellz. Liver, kidneys, heart, who needs um if I look awesome? (j/k well mostly haha)
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    Quote Originally Posted by mattrag View Post
    Let us hope till that time comes I can use my wonderful PH to help me look decent haha. Probably not... but oh wellz. Liver, kidneys, heart, who needs um if I look awesome? (j/k well mostly haha)
    lol

    It's funny how resilient the body is that it can be so complex and yet work so well, but all it takes is one thing to set it all in an odd direction.

    On another note, I was clearly meant to live and survive in arctic conditions. lol
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    Spent 3 hours at the lab, this morning.

    The woman who I usually see and talk to pretty frequently was supposed to work, but apparently called in sick, so the other girl got in 20 minutes after the lab was supposed to open. I'd been waiting in my car since just before 8. Some woman got there about 10 minutes after me; she went up to the door and looked in and then looked over and saw me sitting in my car. Once the girl got there to open it up, this woman was out of her car in a flash and right behind her. I was trying to figure out if the was a part-time worker who just didn't have keys or what was going on. I walked in a few seconds after they did and I just sat down. She looked over and saw me; she had clearly seen me before, but didn't feel like acknowledging that, apparently. Since I'm a nice guy, and I had so many tests to get done and would be there for a while, I decided to just let her go. It's just weird how people don't even acknowledge that. Whatever.

    Anyway, got all the fasted stuff drawn (insulin, heavy metals, thyroid antibodies, and original glucose). Then I was stuck there another 2 hours for 2 more draws. Hopefully I'll find out sometime mid next week what the results are before Christmas and the weekend hit. As always, updates will come when I have them.
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    Would be a nice xmas gift to finally know.
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    I'll get the blood work scanned in and added, tomorrow, hopefully.

    Anywho, fasting insulin was good; right in the middle of normal (I'm still interested to see how it would show up post meals and post carbs, though).

    Glucose tolerance test was great; fasting was 89, 1 hour after 75g dextrose was only 95 and 2 hours after it was down to 84. I'd be more interested to see what it jumped to immediately after consumption (~5 minutes), but that's refreshing since I was always so deathly afraid of carbs.

    Heavy metals test all came back good.

    TPO-Ab = 166 (ref range: < 35)

    So, anti-thyroid TPO is significantly high out of range, which would be indicative of Hashimoto's. This is rather frustrating to me since Hashimoto's is the leading cause of hypothyroidism, so one would think a competent GP (but especially the endo I saw after) would have requested anti-thyroid antibodies to rule this out or confirm it. This information comes to me an entire year after the fact. On top of that, I actually requested these to be tested back in May or June and the endo's nurse practitioner said okay, but when I got my results back, no one had ever sent off for it.

    That being said, I'm going to ask my doc if it's worth having Tg-Ab checked, as well, or if that has any relevance in this.

    I still haven't had a chance to talk to him, but one of his office assistants told me over the phone after they got back from Christmas and while I was out of state that his notes indicated that he wanted me to add Synthroid back in. This test showed my TSH at 3.5 and my T4 low OOR (not by a whole lot, though).

    To me, that seems odd and finding the root cause of the autoimmune disorder would seem like the logical step, since exogenous thyroid hormone has done nothing for me despite lowering my TSH to near hyperthyroidism levels. Granted, I've never taken both T4 and T3 together, but when I was on T4, my urine was dark yellow all day long even when drinking 2+ gallons of water/day and that just doesn't seem right. Also, my hair shedding has since become less of a problem. It's still there, but no where near as bad as when I was on T4 (I've also been using N2Shampoo ever since September or whenever and that likely has helped some, too).

    Anywho, the idea of adding T4 back in actually sounds good to me since the T3 has such a short half life, but because of the symptoms I'm hesitant to bring it back in. If I do, I think I'd like to have rT3 tested again to make sure it hasn't crept back up. It was initially high OOR (checked in June) and then I crushed it to low OOR with my 100mcg of T3/day for 10 weeks (last checked in September).

    I'll likely schedule an appointment just to pick his brain about this, since he is great about listening to me and explains things very well (doesn't rush me out, either). I also want to request having hormones (testosterone, free testosterone, estradiol) checked again, since it's been a year since they were last checked and in the past year, I've used very few supplements outside of some staples. I still think I'm going to try to get a 4x saliva cortisol test since my 24-hour urine cortisol test came back high, despite ACTH coming back normal. I'd still kind of be interested to see what LH, FSH and SHBG are, but I don't know how necessary those would be in all of this.

    I'm also curious, could overuse of NO products (namely forms of arginine) cause blood-flow issues? My veins slowly disappeared as far as being raised. It started with the brachials disappearing from my biceps even before I put on much extra weight at all. I'm at a point now where even my forearms don't have raised veins during lifting sessions, which seems odd during heavy arm days/shrugs, etc. My forearms are still quite lean. What's also odd is that the veins in my arms (particularly inner biceps) are much more visible, now, than ever, but not raised in the slightest. That could be because I haven't tanned in quite a while and am pretty pale, though.

    What also made me curious about this was the nurse trying to draw blood from my left arm and getting nothing. She didn't miss, either. She could only get blood from my right arm and that even seemed a bit slow. My ferritin levels have always seemed to be good and a couple months ago, my serum iron level was very high OOR, although this most recent iron test from 3 weeks ago shows it fine (though it doesn't distinguish serum, so I have no clue).

    I'm interested in anyone's thoughts on this, especially.

    This is the second day of me going gluten-free. One thing I'll say is that my bowel movements have been very frequent, today, and fiber hasn't really been all that high (2 tbsp of psyllium husk with my breakfast shake and not much else in the way of fiber) and I actually do feel very good. I did the paleo thing a ways back for a month, but gave it up because I didn't notice anything, but I don't see taking gluten out of my diet being a negative thing, at all. Eventually, I'll try to add some rice back in and potatoes, as well, but initially, I want to keep the majority of my carb sources coming from fruit and veggies; cycling them up and down depending on the day.

    Constantly stuff on my mind and coming up on the 1-year mark of when I was first diagnosed with hypothyroidism.

    As always, I'll update whenever anything comes up.
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    You have to remember alot of Dr.s just dont care about testing. It's all about the all mighty dollar and co pays. And medication they get kick backs on.

    I would demand them to test for hashimoto. Everything fits but that is just my opinion.
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    Quote Originally Posted by Onlychevy6 View Post
    You have to remember alot of Dr.s just dont care about testing. It's all about the all mighty dollar and co pays. And medication they get kick backs on.

    I would demand them to test for hashimoto. Everything fits but that is just my opinion.
    Yeah, the TPO-Ab being what it is pretty well solidifies Hashimoto's being the case and it originating from an autoimmune disorder. It actually makes sense, as my dad has an autoimmune disorder, as well.

    The doctor I have been working with since September in town is great. Like I said, he is the only guy who has appreciated my researching and he doesn't try to rush me out. I just don't know if Tg-Ab is something that needs testing, as well, or if it doesn't matter (not an area of expertise for me).

    The other endo who didn't give me this test apparently wasn't that knowledgeable, though, since they also said rT3 was a pointless test and I should continue 112mcg T4/day despite it being significantly high OOR. And the initial GP I went to for the blood testing wasn't even near helpful, so them overlooking testing the antibodies isn't surprising, either.

    The funny thing is that endo actually was talking to me about TRT because of my test levels (which were still in range, but not where I'd necessarily like to see them; though I certainly wouldn't want to go TRT this early unless I absolutely had to for quality of life).

    I e-mailed the doctor who goes to my gym about these results to get his opinion on it. If I recall correctly, he was the one who said that Hashimoto's is more of finding out what's causing the problem and not just treating it with thyroid hormone. That makes the most sense to me, particularly since thyroid hormone hasn't done anything for me thus far (relatively speaking).
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    Exactly. Keep doing your thing. Hashimoto is a wild thing. Watching my mom experience the things she has is amazing. Of course she also has m.s.
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    Updated post #2 on page 1 with the new blood tests.

    After some looking, I noticed they put the accession date as 12-17 (Saturday), when I had this all done on 12-16 (Friday). I know no one else went in and had the exact same testing done as myself, but I have to admit, I don't like seeing errors like that when it comes to things of this nature.
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    keep it up man!
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    Quote Originally Posted by MidwestBeast View Post
    Yeah, man. He's the doc that prescribed my the Cytomel and actually listened about the importance of keeping rT3 down.

    The insulin intrigues me because my dad is diabetic and has to take insulin throughout the day. I stopped eating carbs for the most part for several years until I moved and my friend turned me onto Anabolic Pump. I used some form of insulin mimetic or GDA before EVERY carb-heavy meal (honestly, more than 30g or so) for a year and a half. I stopped the use of them around May when I cut out all supplements to try and get a better judgment on what was causing the problems. Things degraded much more rapidly from June-now.

    My weight doesn't really drastically jump up. But it will climb, and not fall (outside of water weight). Insulin problems would logically (in my opinion) explain nutrients being shuttled predominantly to fat and hindering weight loss.

    However, the fact that I took 100mcg of T3 daily for 10 weeks and didn't lose any weight (or strength) still doesn't sit well with me (making me think thyroid antibody issues).


    And the absolute inability to lose weight (not just having to starve myself and train like a mad man to lose) started ~4 months after I had been living in KY. That's what makes me wonder about the heavy metals. If the pipes around here are that bad, since I drink about 2 gallons of water/day, it would make sense.

    So, we'll see. Friday will be the testing and hopefully before Christmas I'll get a call from the doc to tell me what's up.
    thats very fuked up! i wont evne pass 50mcg but 100mcg for weeks and no effects!?!? if its lagit then thats VERY odd.
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    Quote Originally Posted by Blergs View Post
    thats very fuked up! i wont evne pass 50mcg but 100mcg for weeks and no effects!?!? if its lagit then thats VERY odd.
    Haha yeah, beyond odd. It was legit, pharm-grade and it brought my TSH down to 0.44 from ~3, so it was working in that regard, at least and it also crushed the rT3, which was good. It's just very strange that anything could keep that much T3 from making one lose weight, even if it was muscle.
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    Well, I spent the last few hours putting all of my (relevant) lab work into an Excel spreadsheet so I could see everything in one picture versus having to shuffle pages or pdf's back and forth. It's fairly interesting.

    I was mainly doing it for my thyroid panels, but I ended up including some other hormonal categories (cortisol, ferritin/iron, liver values, blood values). I've seen liver numbers do a bit of a 180 over the course of this and some other numbers were either high or low out of range, so I felt they were worth including so I know to have a little mental flag in case anything else pops up in the future.

    So my TSH got down to just below 2 on 112mcg of T4 and then upping to 100mcg of T3/day took it down to 0.13 (technically hyper, though I never felt/noticed any symptoms). After being on just 25mcg T3/day, it's gone back up to 3.5, now.

    My Free T4 has also been low out of range ever since I went onto T3-only, so adding the T4 dose back in would certainly seem to be a smart move. That's what the doc has suggested and it certainly makes sense, though I'd like to get rT3 checked one last time to make sure it's still low OOR or in range.

    I'm curious how important Free T4 levels are in the big scheme of things. I wonder if them being that low could be hindering anything.

    I'm going to try to get into my doc this week and ask him that as well as get some more general hormonal panels done just since it's been a year since doing those last and I want that to be an annual thing. So, on my list of things I want to get checked are:


    - Testosterone
    - Free Testosterone
    - Estradiol
    - SHBG
    - FSH
    - LH
    - Prolactin
    - Cortisol
    - Total T4
    - Free T4
    - Total T3
    - Free T3
    - T3 Uptake
    - Reverse T3
    - Tg-Ab
    - AST
    - ALT
    - Cholesterol panel
    - White Blood Cell Count
    - HMC


    The document is on a jump drive and it won't load back up for some reason, so this is all from memory and my mind has gone to garbage right now, so I may be overlooking some things.

    Test, free test, and estradiol are all things I had checked last January and want to continue having checked on an annual basis. The thyroid tests are all pretty obvious. The SHBG, LH and FSH are things I've wanted checked, anyway, and to me aren't unwarranted based on the high prolactin. I want the prolactin drawn as an AM since the only time I had it checked and it was high OOR (only marginally), it was a PM draw, so it logically should have been lower than normal. The liver values have gone kind of sour with the added weight gain, so I want those checked (both have been high OOR at one point or another); same with the WBC count and HMC. With all of that being what it is, cholesterol is something I want to look into, as well.

    I want to have these tests done before I resume T4 for the first time since June. If I remember anything else, I'll make a note of it.
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    So, yesterday, I had my doctor's appointment and this morning, I had my blood draw. I ended up with a lot of things getting checked, which is good, because I want some things checked at least once a year.

    Everything listed in the post above, except for TgAb (doc said it's not necessary because any antibody level being OOR like my TPO-Ab is shows enough evidence of Hashimoto's so any other level out of wack doesn't make treatment any different). I also had a number of other things checked, including IGF-1 and leptin. As always, I'll post up the results whenever they get back in.

    Tomorrow morning, I'll be starting back in on my T4 in conjunction with T3. I wanted this panel done before I started so I could have an accurate 6-week representation for all my thyroid numbers. The doc wanted me to use Synthroid, specifically, this time around because he said there can be a difference between it and the generics (which I have in fact heard). Sucks paying $14 more for it, but if it works, I don't care lol. I'll be dosing 50mcg T4 and 25mcg T3 for the next 6 weeks and having more blood work, then. I'll likely ask the doc if he can bump the scrip to 112mcg (or an even 100, if they do that dose) so I can pay the same amount and just split the tabs.
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    I'll get everything scanned and uploaded, soon, but here are some highlights from the blood work I had done last week:


    *Note, this panel was done fasting (10+ hour fast) and the morning following a non-lifting day*




    Glucose: 101 H (65-99)
    Calcium: 10.3 (8.5-10.3)
    Albumin: 4.8 (3.5-4.8)
    ALT & AST: both good and in range, now (suspect previous elevation was due to lifting)
    HDL: 40 (40-131)
    LDL: 104 H (0-100)

    Cortisol: 14.2 (8.7-22.4)
    Prolactin: 17.07 H (2.64-13.13) (previously just high OOR, but that was a PM draw)
    LH: 3.46 (1.24-8.62)
    FSH: 4.00 (1.27-19.26)
    SHBG: 27.6 (13.3-89.5)

    Testosterone Bioavailable: 251 (131-682)
    Testosterone Free (calculation): 96 (33-227)
    Free Testosterone %: 2.14 (1.6-2.9)
    Testosterone: 450.18 (205.00-781.00)
    Estradiol: 20 (0-47)


    FT4: 0.51 L (0.58-1.64)
    TSH: 4.96 (0.34-5.60)
    T Uptake: 39.9% (33.7-43.3)
    FT3: 2.79 (2.39-6.79)
    rT3: 130 (90-350)

    Leptin: 10.4 (0.5-12.7)
    IGF-1: 357 (112-402)


    I bolded everything that was "clinically" low or high out of range. However, from some of the others I added, you can see that they're right on the edge of being out of range.

    I'm impressed with IGF-1 being what it is and I'm actually happier with testosterone than what I'd expected. I'd like to see the bioavailable and free test up, but they're not awful. Estradiol being as low as it is, still, I'm very pleased with.

    Free T4 is low; that's due to my not taking in anything aside from cytomel (T3) for the last 6 months. The day after that test, I started back up on 50mcg of Synthroid (brand name, this time, not generic) along with the 25mcg of cytomel (generic) that I take per day. The TSH is nearly as bad as when I was diagnosed hypo a year ago. As I've been on just the 25mcg of T3/day, I've watched that steadily climb higher and higher. Between that and the Hashimoto's, it'll be something I have to pay close attention to, to keep in a low range. Reverse T3 is finally back from low out of range, but nice and low within range, so that's good. The free T3 is surprisingly low, too. Even when I was running the 100mcg of T3/day, it still showed up within range and not all that high, which is interesting.

    The prolactin is clearly a problem/issue. It was barely high out of range last time, but that was an afternoon draw. This was an AM draw, and as I was worried of, it's higher. The dynamic brain MRI I'd had done showed no prolactinomas, but this leads me to question if there is possibly an insulinoma elsewhere in the body. It also makes me wonder if caber would be a smart thing. My instincts say that finding the cause is more important; but I'm noting it.

    Cortisol is looking good, though I'd still like to run a 4x saliva test to rule anything out since my 24-hour urine test came back high out of range several months back.

    Leptin is interesting. I've been reading so much about it, lately, and as I've learned more (particularly in thanks to the article that AM just had in the newsletter), I'm more intrigued by/worried about this, since it's more than just controlling feelings of hunger. I could care less if I'm hungry or not (if I lift, I'm not hungry, if I don't, I am); I have willpower to battle that. But, if signals are being missed to my brain and metabolism is continually slowing through that miscommunication, I'm very much worried about leptin and insulin resistance.

    I'm not sure what to think about the blood glucose level being high out of range in a fasted state. The 2 hour GTT last time showed it not having much of an impact and in fact, the 2 hour mark had a lower blood sugar than fasting. But, if my fasting state is technically high out of range or just really high, is that a problem? That's something I'm wondering about. I also don't know enough about the differences in blood glucose readings versus insulin and not only that, but the utilization of insulin. Again, I go back to questioning the insulin resistance and if that insulin is just going straight into fat instead of doing it's job. I don't know nearly enough about this.

    LH and FSH are both in range, but they seem somewhat low. Again, this is an area I don't have very much knowledge in, either. I'm curious if either are numbers I should be worried or cautious of.

    LDL and HDL are both basically bad. This scares me, to be entirely honest. That has heart attack pre-cursor written all over it. I sadly don't have any former HDL/LDL labs to compare this to, so I don't know if I've always carried numbers closer in this direction or if it's just gone completely downhill since adding all the weight.

    Calcium is also on the border of being high (which has been the case every time I've had it checked), so that's why I don't supplement with external calcium outside of what's in my multi. That's something I've kept an eye on because of its interactions with other hormones and levels in the body.
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    Are the Docs just as confused? They have any 'theories' about what's going on?
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    Very interesting stuff here MWB. Sounds like you got a whole host of problems. Hopefully the docs get get things figured out, otherwise we'll have to search for a Black Series expansion, like Black Cure.
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    Quote Originally Posted by schizm View Post
    Are the Docs just as confused? They have any 'theories' about what's going on?
    Yeah; I've worked with a handful of docs:

    - GP in town a year ago who I got my first blood work through (didn't bother to check thyroid antibodies and just put me on 50mcg T4; TSH results after 6 weeks were 3.7 from 5.7 and she said it was good despite me feeling no different)
    - Endocrinologist in Louisville who bumped me to 112mcg and also mentioned possibly TRT lol (TSH in check after 6 weeks, but no difference in feeling or weight and urine was dark yellow even when drinking 2 gallons H2O/day; also didn't check for thyroid antibodies; checked rT3 after my request, it was high OOR and he said it was a pointless test)
    - GP with endocrinology background in town; he has been awesome and put me on a scrip of 25mcg T3/50mcg T4 (after I'd been running 100mcg T3 on my own for 10 weeks), I then ran just T3 until a week ago (6mo no T4). He has looked at tons of options for me (cortisol, ACTH, prolactin, brain MRI). At this point, he doesn't seem to have any theories (haven't talked to him since this latest blood work came back, though). He was the only one to check thyroid antibodies; so a year after all of this, I finally get diagnosed with Hashimoto's autoimmune disorder.
    - Endocrinologist at University of Louisville who said these are my genetics and the weight gain was normal. Also said I just eat too much/don't burn enough energy...biggest waste of my life.



    So, no theories on my doc's behalf that I'm aware of. I have my suspicions (as noted above), but that's all.
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    Quote Originally Posted by MidwestBeast View Post
    Yeah; I've worked with a handful of docs:

    - GP in town a year ago who I got my first blood work through (didn't bother to check thyroid antibodies and just put me on 50mcg T4; TSH results after 6 weeks were 3.7 from 5.7 and she said it was good despite me feeling no different)
    - Endocrinologist in Louisville who bumped me to 112mcg and also mentioned possibly TRT lol (TSH in check after 6 weeks, but no difference in feeling or weight and urine was dark yellow even when drinking 2 gallons H2O/day; also didn't check for thyroid antibodies; checked rT3 after my request, it was high OOR and he said it was a pointless test)
    - GP with endocrinology background in town; he has been awesome and put me on a scrip of 25mcg T3/50mcg T4 (after I'd been running 100mcg T3 on my own for 10 weeks), I then ran just T3 until a week ago (6mo no T4). He has looked at tons of options for me (cortisol, ACTH, prolactin, brain MRI). At this point, he doesn't seem to have any theories (haven't talked to him since this latest blood work came back, though). He was the only one to check thyroid antibodies; so a year after all of this, I finally get diagnosed with Hashimoto's autoimmune disorder.
    - Endocrinologist at University of Louisville who said these are my genetics and the weight gain was normal. Also said I just eat too much/don't burn enough energy...biggest waste of my life.



    So, no theories on my doc's behalf that I'm aware of. I have my suspicions (as noted above), but that's all.
    Never heard of that one before. I hope you can find something that works for you. My wife has an autoimmune disorder that the docs can't figure out either. She's been diagnosed with Chronic Fatigue, then change to Lupus, then changed to Fibromyalgia and possible something else. This has been going on for over three years. Gets pretty frustrating.
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    SHBG is low you lucky ****. Easier test binding and high igf1 man u got good natrual genes, besides the test low, i bet being on cycle works wonders on you huh?
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    Quote Originally Posted by Jasen View Post
    SHBG is low you lucky ****. Easier test binding and high igf1 man u got good natrual genes, besides the test low, i bet being on cycle works wonders on you huh?
    Only cycle I've ever ran is epi bridged into h-drol, about 15 months ago. It was a resort (before I did any blood work) to attempt to cut since nothing else would work. So unfortunately I haven't been able to reap the benefits of that.

    I'm pleased with the IGF-1 and the SHBG was in good order, too; same with estradiol.

    And overall test really isn't bad; could be better, but it's not bad.




    I'm trying to figure out what the heck could cause the high prolactin since they didn't find any prolactinomas (tumors on the pituitary). Like I said, I'm still suspicious of insulinomas or tumors elsewhere in the body. Along with that, the fasting blood sugar being high is odd/unsettling and the cholesterol numbers make me very uncomfortable.
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    wow that is rough bro.... wtf man...
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    Quote Originally Posted by mattrag View Post
    wow that is rough bro.... wtf man...
    You're telling me. So now with the fasting blood sugar being what it is and the cholesterol levels, I fall into the lovely category of Syndrome X/Metabolic Syndrome. The best part is when you look for treatment options, it lists diet and exercise...lol. Hmmmm...I never thought of that!
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    Quote Originally Posted by MidwestBeast View Post
    You're telling me. So now with the fasting blood sugar being what it is and the cholesterol levels, I fall into the lovely category of Syndrome X/Metabolic Syndrome. The best part is when you look for treatment options, it lists diet and exercise...lol. Hmmmm...I never thought of that!
    Jeez man... what is one to do eh? You work hard in the gym and in the kitchen and still get no break... Hopefully with these tests you can get some good advice for improvement. I am at a loss lol.
    Your fasting insulin and triglycerides were okay before? perhaps they were always elevated?
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    Wow, that is mind boggling and frustrating!

    I just did a quick google search for metabolic syndrome treatment and in the first two pages the only thing that didn't say diet and exercise said Metformin perscription and insulin injections.

    But seriously you should consider stopping smoking.
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