AICAR and AP, Interesting Statements!!!

Mulletsoldier

Mulletsoldier

Binging on Pure ****ing Rage
Awards
2
  • Established
  • Legend!
AICAR is an AMPk [adenosine monophosphate kinase] agonist that has been shown to regulate both glucose homeostasis, as well as adaptive thermogenesis. You may have seen recent research on it heralding it as, "Exercise in a pill". This is said because it upregulates PPARa [peroxisome proliferated activated receptor alpha] gene expression in adipocytes, thereby controlling target genes that control how your body tells your fat cells how to react in energy demands - i.e., tells fat cells to expend themselves! Ostensibly, this is all caused by AMPk regulation.

In reading some old research, I found this interesting:

Intriguingly, the effects of berberine on AMPK activity in adipocytes
were more pronounced than that of 5-aminoimidazole-4-
carboxamide riboside (AICAR), a known AMPK agonist
(Fig. 5A)
http://www.shmu.edu.cn/courses/2008aut/20080916/20081016/Zhangzeng Berberine_ a Natural Plant__ Product_ Activates AMPActivated protein kinase with beneficial metabolic__ effects in diabetic and insulin-resistant states.pdf

Considering AICAR is being considered as the newest product in a sophisticated line of possible doping agents, this statement is absolutely phenomenal!!
 
Mulletsoldier

Mulletsoldier

Binging on Pure ****ing Rage
Awards
2
  • Established
  • Legend!
Ah that one works. I have this one saved on my comp already too, great article though. I thought it was one comparing AICAR vs Berberine.
Nope, just measuring the attenuation of lipogenic gene expression by BBR, mostly mediated by AMPk.
 
Thread starter Similar threads Forum Replies Date
Anabolics 14
Supplements 2
mnemotron Cycle Logs 11
biggfly Supplements 3
biggfly Weight Loss 3

Similar threads


Top