AICAR is an AMPk [adenosine monophosphate kinase] agonist that has been shown to regulate both glucose homeostasis, as well as adaptive thermogenesis. You may have seen recent research on it heralding it as, "Exercise in a pill". This is said because it upregulates PPARa [peroxisome proliferated activated receptor alpha] gene expression in adipocytes, thereby controlling target genes that control how your body tells your fat cells how to react in energy demands - i.e., tells fat cells to expend themselves! Ostensibly, this is all caused by AMPk regulation.
In reading some old research, I found this interesting:
Considering AICAR is being considered as the newest product in a sophisticated line of possible doping agents, this statement is absolutely phenomenal!!
In reading some old research, I found this interesting:
http://www.shmu.edu.cn/courses/2008aut/20080916/20081016/Zhangzeng Berberine_ a Natural Plant__ Product_ Activates AMPActivated protein kinase with beneficial metabolic__ effects in diabetic and insulin-resistant states.pdfIntriguingly, the effects of berberine on AMPK activity in adipocytes
were more pronounced than that of 5-aminoimidazole-4-
carboxamide riboside (AICAR), a known AMPK agonist
(Fig. 5A)
Considering AICAR is being considered as the newest product in a sophisticated line of possible doping agents, this statement is absolutely phenomenal!!