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Nitric oxide supplements are extremely popular pre-workout supplements. But does it work? Check this article:
Does Nitric Oxide (NO) Supplements work?
Does Nitric Oxide (NO) Supplements work?
Nutrition. 2006 Sep;22(9):872-81.
Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.
Campbell B, Roberts M, Kerksick C, Wilborn C, Marcello B, Taylor L, Nassar E, Leutholtz B, Bowden R, Rasmussen C, Greenwood M, Kreider R.
Exercise and Sport Nutrition Laboratory at the Center for Exercise, Nutrition, and Preventative Health Research, Department of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, USA.
Abstract
OBJECTIVE: We evaluated the pharmacokinetics, safety, and efficacy of l-arginine alpha-ketoglutarate (AAKG) in trained adult men.
METHODS: Subjects participated in two studies that employed a randomized, double-blind, controlled design. In study 1, 10 healthy men (30-50 y old) fasted for 8 h and then ingested 4 g of time-released or non-timed-released AAKG. Blood samples were taken for 8 h after AAKG ingestion to assess the pharmacokinetic profile of L-arginine. After 1 wk the alternative supplement was ingested. In study 2, which was placebo controlled, 35 resistance-trained adult men (30-50 y old) were randomly assigned to ingest 4 g of AAKG (three times a day, i.e., 12 g daily, n = 20) or placebo (n = 15). Participants performed 4 d of periodized resistance training per week for 8 wk. At 0, 4, and 8 wk of supplementation the following tests were performed: clinical blood markers, one repetition maximum bench press, isokinetic quadriceps muscle endurance, anaerobic power, aerobic capacity, total body water, body composition, and psychometric parameters tests. Data were analyzed by repeated measures analysis of variance.
RESULTS: In study 1, significant differences were observed in plasma arginine levels in subjects taking non-timed-release and timed-release AAKG. In study 2, significant differences were observed in the AAKG group (P < 0.05) for 1RM bench press, Wingate peak power, blood glucose, and plasma arginine. No significant differences were observed between groups in body composition, total body water, isokinetic quadriceps muscle endurance, or aerobic capacity.
CONCLUSION: AAKG supplementation appeared to be safe and well tolerated, and positively influenced 1RM bench press and Wingate peak power performance. AAKG did not influence body composition or aerobic capacity.
Nitric Oxide Supplements for Sports. pg. 14-20
DOI: 10.1519/SSC.0b013e3181bdaf89
Bloomer, Richard J PhD, CSCS
Article
NITRIC OXIDE-STIMULATING DIETARY SUPPLEMENTS ARE ARGUABLY THE MOST WIDELY ADVERTIZED AND PROMOTED AGENTS IN THE SPORT/BODYBUILDING NUTRITION ARENA TODAY. UNFORTUNATELY, THESE PRODUCTS HAVE LITTLE SCIENTIFIC EVIDENCE FOR EFFECT, DESPITE THE MASSIVE HYPE THAT SURROUNDS THE AGGRESSIVE ADVERTISING CAMPAIGNS. WHILE SOME ANECDOTAL REPORTS SUGGEST A POTENTIAL BENEFIT FROM USING THESE PRODUCTS, ONE CANNOT RULE OUT THE POSSIBILITY OF A "PLACEBO EFFECT." THE PURPOSE OF THIS REVIEW IS TO PRESENT INFORMATION RELATED TO THE ROLE OF NITRIC OXIDE IN SPORT PERFORMANCE AND TO PROVIDE AN OVERVIEW OF THE SCIENTIFIC RATIONALE FOR THE USE OF NUTRITIONAL SUPPLEMENTS AIMED AT INCREASING NITRIC OXIDE. (C) 2010 National Strength and Conditioning Association
In fact, if you do a pub med search of "NO supplements exercise", aside from the first study, all the rest are done in clinical situations: ie, heart patients, etc. And from this and in vitro research, the supplement companies extrapolate the data and try to connect it to what would occur in a healthy, trained human.Nitric oxide–stimulating dietary supplements
are widely available and
aggressively marketed to the sports/
bodybuilding community. Unfortunately,
these products have little direct
scientific evidence for effect and depend
largely on borrowed science
related to research done on isolated
and intensified dosing of certain ingredients,
in particular L-arginine. This,
coupled with paid endorsements from
top athletes, and a bit of the placebo
effect thrown in for good measure,
have catapulted this class of supplement
to the top in the bodybuilding
world.With the exception of one study
(5), there exist no published scientific
reports to indicate that the dietary
supplements currently being marketed
as ‘‘nitric oxide stimulators’’ have
proven efficacy. Many research questions
remain to be answered with
regard to this class of dietary supplement,
including GPLC. These include
questions pertaining to whether such
products can reliably (a) stimulate an
increase in nitric oxide production, (b)
stimulate an increase in blood flow, (c)
stimulate an increase in nutrient and
oxygen transport to exercising muscle,
(d) improve exercise performance and
recovery, and (e) increase muscle mass.
Such claims are made routinely within
the advertisements for such supplements.
However, without welldesigned
research studies focused on
the actual product of sale, answers to
such questions will remain unknown
and this field will remain much more
hype than effect.
Right, but there doesn't seem (I have not seen) any strong relationship between NO production and protein synthesis.Arginine based products do jack, but GPLC has some solid data regarding NO production. Arginine for NO production is about as useful as glutamine.
Not to my knowledge. The main scope of the GPLC studies were to see its efficacy on anaerobic threshold. They found the increased NO production in subsequent studies seeking some sort of MoA.Right, but there doesn't seem (I have not seen) any strong relationship between NO production and protein synthesis.
What would be interesting to see is if GPLC increases blood flow to a muscle during exercise beyond what is already occuring. You could use leg extensions as an exercise and measure via pleythosmography (sp?) to see if it makes a significant impact. Has this (or similar) been done that you know of?
Br
I wouldn't call it solid data. They measured nitrate levels at 0 , 5 and 10 minutes and they found a significant difference! That probably will do jack for blood flow. As Br wrote, now combine that with resistance training where there is already blood flow and you probably get nothing.Arginine based products do jack, but GPLC has some solid data regarding NO production. Arginine for NO production is about as useful as glutamine.
While NO supplements may benefit aerobic performance, they are not marketed by the majority of the supplement industry as such. They are aggressively marketed as ergogenic aids of strength, power, and hypertrophy; however, they appear to have no significant impact upon such. Therefore, I think we need to educate, or at least make available the facts about NO supplements WRT strength and size to readers on this and other forums we belong to.Nutrition. 2006 Sep;22(9):872-81.
Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.
Campbell B, Roberts M, Kerksick C, Wilborn C, Marcello B, Taylor L, Nassar E, Leutholtz B, Bowden R, Rasmussen C, Greenwood M, Kreider R.
Exercise and Sport Nutrition Laboratory at the Center for Exercise, Nutrition, and Preventative Health Research, Department of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, USA.
Abstract
OBJECTIVE: We evaluated the pharmacokinetics, safety, and efficacy of l-arginine alpha-ketoglutarate (AAKG) in trained adult men.
METHODS: Subjects participated in two studies that employed a randomized, double-blind, controlled design. In study 1, 10 healthy men (30-50 y old) fasted for 8 h and then ingested 4 g of time-released or non-timed-released AAKG. Blood samples were taken for 8 h after AAKG ingestion to assess the pharmacokinetic profile of L-arginine. After 1 wk the alternative supplement was ingested. In study 2, which was placebo controlled, 35 resistance-trained adult men (30-50 y old) were randomly assigned to ingest 4 g of AAKG (three times a day, i.e., 12 g daily, n = 20) or placebo (n = 15). Participants performed 4 d of periodized resistance training per week for 8 wk. At 0, 4, and 8 wk of supplementation the following tests were performed: clinical blood markers, one repetition maximum bench press, isokinetic quadriceps muscle endurance, anaerobic power, aerobic capacity, total body water, body composition, and psychometric parameters tests. Data were analyzed by repeated measures analysis of variance.
RESULTS: In study 1, significant differences were observed in plasma arginine levels in subjects taking non-timed-release and timed-release AAKG. In study 2, significant differences were observed in the AAKG group (P < 0.05) for 1RM bench press, Wingate peak power, blood glucose, and plasma arginine. No significant differences were observed between groups in body composition, total body water, isokinetic quadriceps muscle endurance, or aerobic capacity.
CONCLUSION: AAKG supplementation appeared to be safe and well tolerated, and positively influenced 1RM bench press and Wingate peak power performance. AAKG did not influence body composition or aerobic capacity.
That's why I said arginine based supplements are not effective. I never said that NO isn't a solid ergogenic.
The one study you posted about arginine supplement is one that I have not seen before and would have to see the full text to really give an assessment.
It is really difficult to find good data out there in the supplement field because there really is no money in it. Generally speaking, we have to take what we can get.Heres another recent article supporting L-ARG supplements
EFFECTS OF ARGININE-BASED SUPPLEMENTS ON THE PHYSICAL WORKING CAPACITY AT THE FATIGUE THRESHOLD
Clayton L Camic, Terry J Housh, Jorge M Zuniga, Russell C Hendrix, et al. Journal of Strength and Conditioning Research. Champaign: May 2010. Vol. 24, Iss. 5; pg. 1306, 7 pgs
Abstract (Summary)
The purpose of the present study was to examine the effects of daily oral administration of arginine-based supplements for 4 weeks on the physical working capacity at the fatigue threshold (PWC^sub FT^). The PWC^sub FT^ test is an electromyographic (EMG) procedure for estimating the highest power output that can be maintained without neuromuscular evidence of fatigue. The study used a double-blind, placebo-controlled design. Fifty college-aged men (mean age ± SD = 23.9 ± 3.0) were randomized into 1 of 3 groups: (a) placebo (n = 19); (b) 1.5 g arginine (n = 14); or (c) 3.0 g arginine (n = 17). The placebo was microcrystalline cellulose. The 1.5-g arginine group ingested 1.5 g of arginine and 300 mg of grape seed extract, whereas the 3.0 g arginine group ingested 3.0 g of arginine and 300 mg of grape seed extract. All subjects performed an incremental test to exhaustion on a cycle ergometer to determine their PWC^sub FT^ before supplementation (PRE) and after 4 weeks of supplementation (POST). Surface EMG signals were recorded from the vastus lateralis using a bipolar electrode arrangement during the incremental tests for the determination of the PRE and POST supplementation PWC^sub FT^ values. There were significant mean increases (PRE to POST) in PWC^sub FT^ for the 1.5 g (22.4%) and 3.0 g (18.8%) supplement groups, but no change for the placebo group (-1.6%). These findings supported the use of arginine-based supplements, at the dosages examined in the present investigation, as an ergogenic aid for untrained individuals. [PUBLICATION ABSTRACT]
The primary mechanism of NO is increased vasodilation and hence increased blood flow. The effect of increased exercise tolerance and o2 cost is speculated to be due to some direct mitochondrial/contractile mechanism and increased o2 supply.No they aren't going to effect bodycomposition or strength, but thats not what NO does in the body, so why would you expect such results. NO also does not increase blood flow, and would not be beneficial anyways considering the flow of blood is a very complex mechanism that requires careful coordination between the heart and vasculature. An external mechanism speeding up the flow of blood would subsequently have to effect heart rate, stroke volume, cardiac output etc..
The primary mechanism of NO is increased vasodilation and hence increased blood flow. The effect of increased exercise tolerance and o2 cost is speculated to be due to some direct mitochondrial/contractile mechanism and increased o2 supply.
The studies you posted used beet root juice to cause an increase in NO. It seems like there is a different mechanism to generate NO besides the arginine one and the beet root juice and sodium nitrate works by this way. I guess you won't see too many companies promoting the beet root juice.
And almost most studies which used PURE arginine failed to show an increase in NO. The studies which did show an increase are either supplemental ones which contains other ingredients or mix of arginine and other products (grape seed extract and such).
Anyone wanna try beetroot juice before training?
If a blood vessel dilates whether in muscle or not, it will increase blood flow (lowering the peripheral resistance to flow). If exercise, the dilation and blood flow might be saturated that an increased NO might not have an effect. There are studies which shows both though.Vasodilation in various vessels does not mean increases blood flow to muscle tissue. Vasodilation is just a mechanism to control the pressure gradient in blood vessels, if you just dilate all vessels the pressure would drop dramatically and we would pass out.
I agree that my grammar is pretty bad and I don't really care about it in a forum post. But I do need to work on it.My favorite supplement that you don't NO is grammar.