What is the maxium dose of PEA you've dosed?
- 02-14-2007, 06:36 PM
- 02-14-2007, 06:55 PM
- 02-14-2007, 08:23 PM
02-14-2007, 08:26 PM
I think I took 350mg with 200mg Hordenine as my largest one time dose....I was very dissapointed with PEA in that it works once (or twice) but then a tolerance hangs around for a long time after.
My first doses were in the 100-200mg range.
02-14-2007, 09:36 PM
Example Test is the real thing
Andro(or like 1ad) is a deriv
Is Pea the main one, that the amino acid Phenylalaine covert too or is it switched around?
Science I know=)
02-14-2007, 10:10 PM
phenylalanine converts to PEA. It also converts to other things (PEA being one of them.)
02-14-2007, 11:34 PM
I used it a couple time at 200mg, didnt notice much. Went up to 400mg and still didnt notice jack. I stick with Phenibut a few hours before a few drinks (coupled with about 4-5 clear edge), that's been my favorite relax stack as of late. I might try to get a hold of some hordenine to see if that helps with the PEA.
02-14-2007, 11:36 PM
Highest Ive gone was 225mg with 75mg of hordenine. I'm lucky as I don't seem to ever build up a tolerance to the stuff. Anything over 225mg just gives me a headache. Too bad I have never responded to phenibut as that sounds kind of nice as well (6g wont even phase me)
02-14-2007, 11:56 PM
6 grams of phen would have me dizzy for a few days and covering the porceline thrown with a previous meal. I went as high as about 2.5-3 grams and the 2nd day after I was extremely dizzy and somewhat nautious so I try to keep it right under 2 grams. How does PEA feel? I just get kinda relaxed, less anxious, and more talkative on phen.
02-15-2007, 09:07 AM
02-15-2007, 06:28 PM
Thought this be of interest:
effect of PEA replacement
Sabelli H; Fink P; Fawcett J; Tom C
Rush University and the Center for
Creative Development, Chicago, Illinois, USA.
J Neuropsychiatry Clin Neurosci, 1996 Spr, 8:2, 168-71
Phenylethylamine (PEA), an endogenous neuroamine, increases attention and activity in animals and has been shown to relieve depression in 60% of depressed patients. It has been proposed that PEA deficit may be the cause of a common form of depressive illness. Fourteen patients with major depressive episodes that responded to PEA treatment (10-60 mg orally per day, with 10 mg/day selegiline to prevent rapid PEA destruction) were reexamined 20 to 50 weeks later. The antidepressant response had been maintained in 12 patients. Effective dosage did not change with time. There were no apparent side effects. PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance.
02-15-2007, 07:27 PM
I'm currently taking 2.5mg mg/day selegiline, I wonder if that would prevent rapid PEA destruction ?
02-16-2007, 01:12 AM
02-16-2007, 10:49 AM
02-16-2007, 11:04 AM
02-16-2007, 12:33 PM
02-16-2007, 06:10 PM
02-16-2007, 07:25 PM
02-16-2007, 07:29 PM
Here we go.
L-Phenylalanine (LPA) is an electrically-neutral amino acid, one of the twenty common amino acids used to biochemically form proteins, coded for by DNA. L-phenylalanine is used in living organisms, including the human body, where it is an essential amino acid. L-phenylalanine can also be converted into L-tyrosine, another one of the twenty protein-forming amino acids. L-tyrosine is converted into L-DOPA, which is further converted into dopamine, norepinephrine, and epinephrine (latter three are known as the catecholamines).
D-phenylalanine (DPA), can be synthesized artificially. D-phenylalanine can be converted only into phenylethylamine. D-phenylalanine is a non-protein amino acid, meaning that it does not participate in protein biosynthesis. D-phenylalanine and other D-amino acids are, however, found in proteins, in small amounts, particularly aged proteins and food proteins that have been processed. The biological functions of D-amino acids remain unclear. Some D-amino acids, such as D-phenylalanine, may have pharmacologic activity.
DL-phenylalanine is a racemic mixture of phenylalanine - it contains 50 % each of D and L enantiomers. DL-Phenylalanine is marketed as a nutritional supplement for its putative analgesic and antidepressant activities.
The putative analgesic activity of DL-phenylalanine may be explained by the possible blockage by D-phenylalanine of enkephalin degradation by the enzyme carboxypeptidase A. The mechanism of DL-phenylalanine's putative antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
02-16-2007, 08:13 PM
Yeah, D and L are enantiomers, so they sythesize a racemic product; hence, D,L- phenylalanine.
Originally Posted by Andrew Novick
02-16-2007, 08:37 PM
02-16-2007, 09:33 PM
Both increase PEA levels, Pea directly and L-phenyalanine indirectly by acting directly as a precursor. Nice
02-16-2007, 11:51 PM
To feel any significant effects from PEA, you'll need an MAO-B inhibitor at least 15-20 minutes beforehand (up to 4 hours beforehand depending on the compound).
5mg Selegeline (Deprenyl) works wonders.
Follow it up with 100-200mg for a noticeable mood elevation, or 600-800mg for a full on euphoric adventure. I've gone up to 1g, but that was a mistake. Unpleasant to say the least.
Slight nausea is common when it starts to kick in, even at the low doses...but it's mild and acute.
Some people don't get much out of it other than side effects, but plenty of folks (myself included) find it to be a hell of a compound.
One thing is for sure, it tastes worse than a burning tire.
Edit: One more thing, Selegeline is better absorbed with food, the PEA is better absorbed without. You can take the Selegeline with a small amount of food, then wait 45min or so to ingest the PEA if you're not feeling the effects from taking both on an empty stomach.
02-17-2007, 01:36 AM
Thanks for that Dr Gozo does No sell Selegeline. If not Hordinine would be taken the same way right? Forty five minutes before
Another thing PEA can be taking anytime right?
02-17-2007, 02:15 AM
02-17-2007, 02:17 AM
02-17-2007, 08:34 AM
02-18-2007, 03:03 PM
02-18-2007, 04:47 PM
02-18-2007, 06:15 PM
Took a dose of 800mg today and talk about a rush,first it weas euphoric then my skin turned red like a niacin rush and I felt warm,it lasted for about 1 hour.I would not recomend doing this everyone is different and you may have a bad reaction.PS: 1 hour later the toilet was calling...
02-18-2007, 06:49 PM
02-18-2007, 10:19 PM
02-18-2007, 10:52 PM
02-18-2007, 11:35 PM
02-19-2007, 01:26 AM
It works mainly by selectively inhibiting monoamine-oxidase B, which is the enzyme responsible for eliminating dopamine, so this leads to increased brain levels of dopamine.
When PEA is taken orally, MAO-B degrades the compound rapidly, so not much of an effect is felt (although some effect can be noticed, it's not extremely pronounced). This will vary from person to person as well depending on how efficiently their body degrades the PEA.
By taking the deprenyl and knocking out MAO-B, you feel a pronounced effect from the PEA since it remains active in the brain. Hordenine has a similar effect on MAO-B, but not as much.
A high dose of PEA with an MAO-B inhibitor leads to intense euphoria, so much that it will take your breath away for a few minutes, and the euphoria lasts from 45 minutes up to a couple of hours. The higher the dose, the worse the after effect. Feelings of agitation and irritiability and extreme sobriety typically follow the experience.
The high doses (600-800mg) are fun to try occasionaly, but I would stick to the 100-200mg range coupled with an MAO-B inhibitor for regular use as a mood elevator.
02-19-2007, 02:48 AM
02-19-2007, 05:23 AM
Huperzine is a name I hear thrown out a lot with PEA for it's MAOI capabilities.
~ Nothing can kill the Grimace!!
02-19-2007, 06:01 AM
02-19-2007, 06:02 PM
Selegiline is called a "maoB inhibitor" and not just a "mao inhibitor" because it selectively and preferentially inhibits the mao degrading dopamine and apperently PEA among others no doubt but not all amines.At high doses tho it also inhibits maoA. How much of a role PEA plays in depression no doubt depends on that specific individual biochemistry,some need more serotonin,some norepinephrine,some dopamine and maybe some PEA.You don't see the "cheese effect" with selegiline which makes it far safer than the older standby mao's like Nardil,Parnate ect.Hence the selectivity.
One caveat tho: with PEA I could imagine it raising blood pressure at least transiently so if you have high blood pressure that would be a contradiction to it's use.This also applys to L and DL Phenylalanine by the way.
02-20-2007, 08:03 PM
Huperzine is an acetylcholinesterase inhibitor, not an MAO-B inhibitor.Huperzine is a name I hear thrown out a lot with PEA for it's MAOI capabilities.
Deprenyl (Selegeline). Hordenine would be a 2nd choice.What MAO-B inhibitor(s) do you recommend for the Intense euphoria ?
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