2:1:1 BCAA ratio-Does the Science exist?

[USPlabsRep]

or Is it even real?

who needs answers?

 

[Admin]

 

[NewAgeMayan]

define 'exist'

 

[mr.cooper69]

The evidence is weak and irrelevant to our populations. It's extrapolated from in vitro biochemistry regarding leucine metabolism. As far as I know, nothing compares the efficacy of different ratios so calling it the only proven ratio is marketing bs. I've seen tons of bcaa studies, all with different ratios...those don't count as proven?

Of course, these claims were made at the same time that they said megadosing bcaas yields gains comparable to AAS and that a study was about to be published (never happened obviously). Such is marketing

 

[schizm]

Seems like there's been more recent studies on a higher leucine ratio...?

Oh, and there is no spoon.

 

[mw1]

I think 2:1 are just Pink magic

 

[johnnyp]

"Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study"
jissn.com/content/9/1/20 This study used a 2:1:1 ratio. (sorry can't post links yet)

 

[USPlabsRep]

"Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study"
jissn.com/content/9/1/20 This study used a 2:1:1 ratio. (sorry can't post links yet)

20 grams a day of BCAA. Its safe to assume its not the ratio but the amount consumed? plus the significant limitations to the study as the authors note.

My mind is caught on "well studied" and the "proven" ratio.

 

[USPlabsRep]

The evidence is weak and irrelevant to our populations. It's extrapolated from in vitro biochemistry regarding leucine metabolism. As far as I know, nothing compares the efficacy of different ratios so calling it the only proven ratio is marketing bs. I've seen tons of bcaa studies, all with different ratios...those don't count as proven?

Of course, these claims were made at the same time that they said megadosing bcaas yields gains comparable to AAS and that a study was about to be published (never happened obviously). Such is marketing

leucine is rate limiting...Mega dose or Mega waste?

 

[USPlabsRep]

I think 2:1 are just Pink magic

Ultimate T

 

[Jiigzz]

20 grams a day of BCAA. Its safe to assume its not the ratio but the amount consumed? plus the significant limitations to the study as the authors note.

My mind is caught on "well studied" and the "proven" ratio.

Correct. It is not the ratio but the total dose

 

[Jiigzz]

Ultimate T

Optimize T **

 

[Geoforce]

Have never noticed a difference between the ratios. I've used Modern BCAA, Xtend, Recoverpro, Amino IV, etc. Not saying differences don't exist just that I have not "felt" them in terms of improvement.


Perhaps an even better question would be are BCAA products even worth the money if adequate protein levels are being consumed?

 

[USPlabsRep]

Have never noticed a difference between the ratios. I've used Modern BCAA, Xtend, Recoverpro, Amino IV, etc. Not saying differences don't exist just that I have not "felt" them in terms of improvement.


Perhaps an even better question would be are BCAA products even worth the money if adequate protein levels are being consumed?

well that depends if the amount of protein reaches the Leucine daily limit threshold, timing and its a great alternative to drinking shakes or eating protein. Its a way to get the benefit of protein in another beverage.

 

[USPlabsRep]

Optimize T **

good name

 

[Jiigzz]

well that depends if the amount of protein reaches the Leucine daily limit threshold, timing and its a great alternative to drinking shakes or eating protein. Its a way to get the benefit of protein in another beverage.

Whats the point of reaching MPS if you have no protein to build muscle with?

Both together is best

 

[Geoforce]

well that depends if the amount of protein reaches the Leucine daily limit threshold, timing and its a great alternative to drinking shakes or eating protein. Its a way to get the benefit of protein in another beverage.

A great alternative to drinking a shake is to drink another flavored drink instead?

I use BCAA's but question the necessity of them in the majority of situations considering most of us take in tons of protein to begin with. And I am currently using your BCAA product so I'm not hating!

 

[TheFugitive]

Amino acid supplementation – particularly with branched-chain amino acids (BCAAs) – is a widely accepted means for increasing endurance, muscle performance, and muscle mass.
This said, for all the studies and user reports showing that these aminos are an effective anabolic, and enhance endurance and performance, there are contradictory ones showing less than optimal clinical outcomes.

This begs the question as to, ‘why’ are there studies like “A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during marathon” published in Amino Acids, and “Periexercise coingestion of branched-chain amino acids and carbohydrates in men does not preferentially augment resistance exercise-induced increases in phosphatidylinoisitol 3 kinase/protein kinase B-mammalian target of rapamycin pathway markers indicative of muscle protein synthesis” published in Nutrition Research, or “Branched-chain amino acid supplementation during a 100-km ultra-marathon – a randomized controlled trial” published in Journal of Nutritional Science and Vitaminology, or “Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines” published in Amino Acids?

The answer lies, in our studied evaluation and estimation, in two key areas. First in something called “pharmacokinetics”. And, second, in the fact that science doesn’t remain stagnant – it is fluid and ever changing, and what was true twenty years ago, may not be wholly correct today.

Let’s start with the knowledge that despite their central role in cellular metabolism, amino acids can be inefficiently absorbed by the digestive tract, for a multitude of factors, chiefly including poor solubility in the acidic environment of the stomach. Said plainly – it’s about how aminos are absorbed and taken up that determine whether or not than can have an impact on endurance, muscle performance, and muscle mass. This is what pharmacokinetics is all about … about whether or not the amino acid(s) can get absorbed and taken up and effectively utilized. Which is why every compound ever looked at for pharmaceutical development is examined for its pharmacokinetics. Meaning what happens to the compound from the time it is ingested to the time it is eliminated.

When Best BCAA™ was being developed, the R&D team for BPI Sports set out to fully comprehend what happens and doesn’t happen – from a pharmacokinetic perspective – to BCAAs, and how best to take advantage of emerging science – the newest and the best for creating a product that would produce a positive impact on endurance, muscle performance, and muscle mass.

Best BCAA™ is predicated on the science of oligopeptides as a superior mechanism for improving the absorption and uptake of BCAAs. Oligopeptides, by way of background, are molecules that are linked in a polypeptide chain. In this linked polypeptide chain cutting edge research shows that there is higher plasma amino acid concentrations and greater homogeneity of amino acid absorption. A typical, and excellent example of this, is the study, “Pharmacokinetic assessment of an oligopeptide-based enteral formula in abdominal surgery patients” published in the American Journal of Clinical Nutrition. This is further supported by another oligopeptide research paper from Germany, and published in the German medical journal, Leber, Magen, Darm, “Comparison of enteral resorption rates of free amino acids and oligopeptides”, which documents that while there is an amino acid transport system, there is also a transport system for peptides, which shows marked advantages as compared to amino acids in free form, which use the standard amino acid transport system. Researchers theorize that this is because the peptide carrier system has a ‘bigger transport capacity than the amino acid transport system.’ Another study, “Characterization and nutritional significance of peptide transport in man”, published in the Annals of Nutrition and Metabolism, consistently found that ‘amino acid residues were absorbed more rapidly from di- and tripeptides than from free amino acids’, and that ‘oligopeptide-based nitrogen sources’ are rapidly assimilated.

An analogy to whey proteins might be beneficial, as detailed in Sports Nutrition Insider, in the article entitled “Show Me The Whey: Concentrates Versus Isolates Versus Hydrolysates”, as to the potential advantages of oligopeptide BCAAs as compared to free form … ‘Then there is also hydrolyzed whey protein (also called hydrolyzed whey peptides). When a protein is hydrolyzed is means that it, by technological processes, has been split to smaller chains of amino acids, called peptides. The hydrolytic process mimics our own digestive actions; thus it can be said that hydrolyzed protein is a predigested protein. Hydrolyzed proteins contain mostly di-peptides and tri-peptides, and are absorbed more rapidly than free-form amino acids and much more rapidly than intact (non-hydrolyzed) proteins.’

Are oligopeptide BCAAs superior to free form BCAAs? The science on the way in which compounds such as these are absorbed and transported in humans would certainly suggest so … and, if BPI Sports’ Best BCAA™ wasn’t such a popular product with actual people – the individual people that use the products and determine best if they are actually satisfied with the results – then we wouldn’t even be having this conversation. But, we are having this conversation, and Best BCAA™ is here to stay, because that’s what the countless people that use, believe in, and rely on this product to get them the results that they want say - it is also our common desire to want and expect more from our supplementation.

 

[USPlabsRep]

A great alternative to drinking a shake is to drink another flavored drink instead?

I use BCAA's but question the necessity of them in the majority of situations considering most of us take in tons of protein to begin with. And I am currently using your BCAA product so I'm not hating!

Simply variety...you may be a person who can eat the exact same meal at the exact same time all the time...

 

[USPlabsRep]

Amino acid supplementation – particularly with branched-chain amino acids (BCAAs) – is a widely accepted means for increasing endurance, muscle performance, and muscle mass.
This said, for all the studies and user reports showing that these aminos are an effective anabolic, and enhance endurance and performance, there are contradictory ones showing less than optimal clinical outcomes.

This begs the question as to, ‘why’ are there studies like “A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during marathon” published in Amino Acids, and “Periexercise coingestion of branched-chain amino acids and carbohydrates in men does not preferentially augment resistance exercise-induced increases in phosphatidylinoisitol 3 kinase/protein kinase B-mammalian target of rapamycin pathway markers indicative of muscle protein synthesis” published in Nutrition Research, or “Branched-chain amino acid supplementation during a 100-km ultra-marathon – a randomized controlled trial” published in Journal of Nutritional Science and Vitaminology, or “Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines” published in Amino Acids?

The answer lies, in our studied evaluation and estimation, in two key areas. First in something called “pharmacokinetics”. And, second, in the fact that science doesn’t remain stagnant – it is fluid and ever changing, and what was true twenty years ago, may not be wholly correct today.

Let’s start with the knowledge that despite their central role in cellular metabolism, amino acids can be inefficiently absorbed by the digestive tract, for a multitude of factors, chiefly including poor solubility in the acidic environment of the stomach. Said plainly – it’s about how aminos are absorbed and taken up that determine whether or not than can have an impact on endurance, muscle performance, and muscle mass. This is what pharmacokinetics is all about … about whether or not the amino acid(s) can get absorbed and taken up and effectively utilized. Which is why every compound ever looked at for pharmaceutical development is examined for its pharmacokinetics. Meaning what happens to the compound from the time it is ingested to the time it is eliminated.

When Best BCAA™ was being developed, the R&D team for BPI Sports set out to fully comprehend what happens and doesn’t happen – from a pharmacokinetic perspective – to BCAAs, and how best to take advantage of emerging science – the newest and the best for creating a product that would produce a positive impact on endurance, muscle performance, and muscle mass.

Best BCAA™ is predicated on the science of oligopeptides as a superior mechanism for improving the absorption and uptake of BCAAs. Oligopeptides, by way of background, are molecules that are linked in a polypeptide chain. In this linked polypeptide chain cutting edge research shows that there is higher plasma amino acid concentrations and greater homogeneity of amino acid absorption. A typical, and excellent example of this, is the study, “Pharmacokinetic assessment of an oligopeptide-based enteral formula in abdominal surgery patients” published in the American Journal of Clinical Nutrition. This is further supported by another oligopeptide research paper from Germany, and published in the German medical journal, Leber, Magen, Darm, “Comparison of enteral resorption rates of free amino acids and oligopeptides”, which documents that while there is an amino acid transport system, there is also a transport system for peptides, which shows marked advantages as compared to amino acids in free form, which use the standard amino acid transport system. Researchers theorize that this is because the peptide carrier system has a ‘bigger transport capacity than the amino acid transport system.’ Another study, “Characterization and nutritional significance of peptide transport in man”, published in the Annals of Nutrition and Metabolism, consistently found that ‘amino acid residues were absorbed more rapidly from di- and tripeptides than from free amino acids’, and that ‘oligopeptide-based nitrogen sources’ are rapidly assimilated.

An analogy to whey proteins might be beneficial, as detailed in Sports Nutrition Insider, in the article entitled “Show Me The Whey: Concentrates Versus Isolates Versus Hydrolysates”, as to the potential advantages of oligopeptide BCAAs as compared to free form … ‘Then there is also hydrolyzed whey protein (also called hydrolyzed whey peptides). When a protein is hydrolyzed is means that it, by technological processes, has been split to smaller chains of amino acids, called peptides. The hydrolytic process mimics our own digestive actions; thus it can be said that hydrolyzed protein is a predigested protein. Hydrolyzed proteins contain mostly di-peptides and tri-peptides, and are absorbed more rapidly than free-form amino acids and much more rapidly than intact (non-hydrolyzed) proteins.’

Are oligopeptide BCAAs superior to free form BCAAs? The science on the way in which compounds such as these are absorbed and transported in humans would certainly suggest so … and, if BPI Sports’ Best BCAA™ wasn’t such a popular product with actual people – the individual people that use the products and determine best if they are actually satisfied with the results – then we wouldn’t even be having this conversation. But, we are having this conversation, and Best BCAA™ is here to stay, because that’s what the countless people that use, believe in, and rely on this product to get them the results that they want say - it is also our common desire to want and expect more from our supplementation.

cool! n

 

[The_Old_Guy]

... and then there's the "how much better, is better?" At the end of a year, how many more ounces/pounds of muscle will you have on your frame, by sipping BCAA's vs relying on pre/post workout protein in meals? "Hey! I spent $1500 on BCAA's and have 9 more ounces of muscle than you!" I get it, for a competitor that needs to pay his mortgage, but for the average Joe?

 

[Whacked]

... and then there's the "how much better, is better?" At the end of a year, how many more ounces/pounds of muscle will you have on your frame, by sipping BCAA's vs relying on pre/post workout protein in meals? "Hey! I spent $1500 on BCAA's and have 9 more ounces of muscle than you!" I get it, for a competitor that needs to pay his mortgage, but for the average Joe?

Nice perspective

 

[USPlabsRep]

Whats the point of reaching MPS if you have no protein to build muscle with?

Both together is best

who suggested not to eat protein?

 

[uubiduu]

Amino acid supplementation – particularly with branched-chain amino acids (BCAAs) – is a widely accepted means for increasing endurance, muscle performance, and muscle mass.
This said, for all the studies and user reports showing that these aminos are an effective anabolic, and enhance endurance and performance, there are contradictory ones showing less than optimal clinical outcomes.

This begs the question as to, ‘why’ are there studies like “A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during marathon” published in Amino Acids, and “Periexercise coingestion of branched-chain amino acids and carbohydrates in men does not preferentially augment resistance exercise-induced increases in phosphatidylinoisitol 3 kinase/protein kinase B-mammalian target of rapamycin pathway markers indicative of muscle protein synthesis” published in Nutrition Research, or “Branched-chain amino acid supplementation during a 100-km ultra-marathon – a randomized controlled trial” published in Journal of Nutritional Science and Vitaminology, or “Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines” published in Amino Acids?

The answer lies, in our studied evaluation and estimation, in two key areas. First in something called “pharmacokinetics”. And, second, in the fact that science doesn’t remain stagnant – it is fluid and ever changing, and what was true twenty years ago, may not be wholly correct today.

Let’s start with the knowledge that despite their central role in cellular metabolism, amino acids can be inefficiently absorbed by the digestive tract, for a multitude of factors, chiefly including poor solubility in the acidic environment of the stomach. Said plainly – it’s about how aminos are absorbed and taken up that determine whether or not than can have an impact on endurance, muscle performance, and muscle mass. This is what pharmacokinetics is all about … about whether or not the amino acid(s) can get absorbed and taken up and effectively utilized. Which is why every compound ever looked at for pharmaceutical development is examined for its pharmacokinetics. Meaning what happens to the compound from the time it is ingested to the time it is eliminated.

When Best BCAA™ was being developed, the R&D team for BPI Sports set out to fully comprehend what happens and doesn’t happen – from a pharmacokinetic perspective – to BCAAs, and how best to take advantage of emerging science – the newest and the best for creating a product that would produce a positive impact on endurance, muscle performance, and muscle mass.

Best BCAA™ is predicated on the science of oligopeptides as a superior mechanism for improving the absorption and uptake of BCAAs. Oligopeptides, by way of background, are molecules that are linked in a polypeptide chain. In this linked polypeptide chain cutting edge research shows that there is higher plasma amino acid concentrations and greater homogeneity of amino acid absorption. A typical, and excellent example of this, is the study, “Pharmacokinetic assessment of an oligopeptide-based enteral formula in abdominal surgery patients” published in the American Journal of Clinical Nutrition. This is further supported by another oligopeptide research paper from Germany, and published in the German medical journal, Leber, Magen, Darm, “Comparison of enteral resorption rates of free amino acids and oligopeptides”, which documents that while there is an amino acid transport system, there is also a transport system for peptides, which shows marked advantages as compared to amino acids in free form, which use the standard amino acid transport system. Researchers theorize that this is because the peptide carrier system has a ‘bigger transport capacity than the amino acid transport system.’ Another study, “Characterization and nutritional significance of peptide transport in man”, published in the Annals of Nutrition and Metabolism, consistently found that ‘amino acid residues were absorbed more rapidly from di- and tripeptides than from free amino acids’, and that ‘oligopeptide-based nitrogen sources’ are rapidly assimilated.

An analogy to whey proteins might be beneficial, as detailed in Sports Nutrition Insider, in the article entitled “Show Me The Whey: Concentrates Versus Isolates Versus Hydrolysates”, as to the potential advantages of oligopeptide BCAAs as compared to free form … ‘Then there is also hydrolyzed whey protein (also called hydrolyzed whey peptides). When a protein is hydrolyzed is means that it, by technological processes, has been split to smaller chains of amino acids, called peptides. The hydrolytic process mimics our own digestive actions; thus it can be said that hydrolyzed protein is a predigested protein. Hydrolyzed proteins contain mostly di-peptides and tri-peptides, and are absorbed more rapidly than free-form amino acids and much more rapidly than intact (non-hydrolyzed) proteins.’

Are oligopeptide BCAAs superior to free form BCAAs? The science on the way in which compounds such as these are absorbed and transported in humans would certainly suggest so … and, if BPI Sports’ Best BCAA™ wasn’t such a popular product with actual people – the individual people that use the products and determine best if they are actually satisfied with the results – then we wouldn’t even be having this conversation. But, we are having this conversation, and Best BCAA™ is here to stay, because that’s what the countless people that use, believe in, and rely on this product to get them the results that they want say - it is also our common desire to want and expect more from our supplementation.

Do you really think everyone will read such long answers? Lol