Daily Agmatine Sulfate dosing
- 07-28-2014, 12:14 PM
- 08-16-2014, 03:06 PM
Agmatine tends to make me sleepy. If taking the supplement solely for spinal pain relief, would a couple grams before bed be sufficient? Or is it better to spread smaller doses throughout the day (instead of one large dose daily)?
- 08-16-2014, 04:12 PM
Agmatine really brings on a sense of focused calm for me. I take 1g on non training days and 1.5 on training pre workout. All day long is a nice mellow focus without any tiredness, and it seems to work very nice with ashwagandha and bacopa for me.Black Lion Research Representative
08-16-2014, 04:12 PM
Found this interesting article on Agmatine today.
08-16-2014, 04:15 PM
It makes me sleepy also. I take all of mine pre-bed when I supplement with agmatine. Makes for a better nights sleep. Also makes me feel "happier" in a sense. I think taking it all at once before bed would be fine for you. Some people do get stomach distress problems with higher dosages though and that would be a reason to spread out your dosages. If you're not getting sides I would say continue taking it as you are.
08-16-2014, 07:45 PM
Is there anything I can take with it to help offset the tiredness during the day? Something that can be taken daily long term. Maybe tyrosine?
08-16-2014, 08:24 PM
Black Lion Research Representative
08-16-2014, 08:53 PM
08-16-2014, 08:59 PM
08-16-2014, 09:08 PM
Taking it after a large meal wouldn't affect it's availability? For some reason was thinking it shouldn't be taken near high protein meals. Could have it mixed up with something else though.
08-16-2014, 10:16 PM
08-17-2014, 12:04 AM
I like 1g preworkout the best. Sometimes I use 500-1000mg in the morning. I always take it in the morning on off days with my other bulk powders. Im going to try the pre bed dosing in a half hour or so with my rezurrect and see how that is.
09-07-2014, 05:03 PM
Sorry for an old thread bump here but trying to figure out the half-life of agmatine effects
Did my own Searching (people still do that???) and found a reference to a 10 minute effect which didn't seem right.
Also one said 2 hours.
Reference was also made to it being able to accumulate as well though.
Looking for any more definitive answers on this if anyone knows
Orbit Nutrition Representative;
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09-07-2014, 05:11 PM
Here we can see up to 12 hours with a single spinal injection:
09-07-2014, 07:04 PM
09-07-2014, 08:11 PM
I guess I'll have to get someone to inject my spine now. What a pain in the ass!
09-07-2014, 10:11 PM
lol, sorry guys, not a whole lot of light has been shed into the agmatinergic system so a rodent study with dosing coming via a intrathecal injection I believe is the best we have to go off of in regards to CNS half-life.
Most of these studies are also administering agmatine systematically vs. the oral route. That's how we're able to see the CNS effects.
I've never seen the full-text, but from the previews Google allows anyone to see, "Pharmacokinetics, Pharmacodynamics and Transport of Agmatine in the Central Nervous System" from John. C Roberts would be a good, comprehensive read.
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