Fenugreek supp useful for PCT

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  1. The smell is one of the reasons I was using it. I love smelling like maple. Chicks wanna put me on their waffles and lick me up... uhhh


  2. So how much fenugreek per day is the suggested dose to add in for pct ??
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  3. I'll start with 2, 650mg pills/night and work up to 6 or 8 over about 4 weeks. That's seems to work well for me. Take it all at once and NOT with food or hormones.

  4. D, why not with food and why only all at once at night??

  5. If your goal is to lower cholesterol assimilation, then take 2 caps, 3x/d with each main meal. It also lowers PH/AS absorption so it must be staggered if your on any oral hormones. For PCT purposes, one dose at night seems to work best. Plus I'm usually taking DHEA, Preg, 7-OH, or something like that daily so it's convenient at night too. I practice the same method with SERMs. One dose all at night, and it peaks early morning with your natural test surge. The dose of Fen must be steadily increased and finally becomes somewhat ineffective at about a month, as the body starts to develope a tolerance at about 2 wks. Then break a few weeks, and you can start all over.
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  6. I'm confused, are people using Fenugreek or Fenugreek Seed for PCT?

  7. Quote Originally Posted by Onslaught
    I'm confused, are people using Fenugreek or Fenugreek Seed for PCT?
    The whole, powdered seed is the common form. When people say fenugreek, they probably mean the seed.

  8. Gotcha, thanks for the clarification Dr. D

  9. Diosgenin, extracted from the root of Wild Yam (Dioscorea villosa), has been reported to demonstrate tremendous opportunity for medical application. Vascular endothelial growth factor-A (VEGF-A) plays an important role in bone-related angiogenesis, a critical process occurring during bone formation and fracture healing. Here we examine whether diosgenin is able to induce VEGF-A expression as well as to promote angiogenesis in osteoblasts. For murine MC3T3-E1 preosteoblast-like cells, VEGF-A mRNA and protein expression appeared to be significantly elevated in response to diosgenin in a concentration-dependent fashion. Conditioned media prepared from cells treated with diosgenin induced strong angiogenic activity in either in vitro or ex vivo angiogenesis assay. Furthermore, diosgenin treatment increased the stability and activity of HIF-1{alpha} protein. Inhibition of HIF-1{alpha} activity by transfection with DN-HIF-1{alpha} significantly diminished diosgenin-mediated VEGF-A up-regulation. The use of pharmacological inhibitors or genetic inhibition revealed that both the PI3K/Akt and p38 signalling pathways were potentially required for diosgenin-induced HIF-1 activation and subsequent VEGF-A up-regulation. Of interest, estrogen receptor binding assay revealed that diosgenin has the strong ability to replace [3H]-estradiol bind to estrogen receptor (IC(50):10 nM). In addition, the specific estrogen receptor antagonists ICI 182,780 and tamoxifen were noted to be able to strongly inhibit the diosgenin-induced src kinase-dependent Akt and p38 MAPK activation. Taken together, such results provide evidence that diosgenin up-regulates VEGF-A and promotes angiogenesis in preosteoblast-like cells by a HIF-1{alpha}-dependent mechanism involving the activation of src kinase, p38 MAPK and Akt signalling pathways via estrogen receptor.
    CONTROLLED LABS - WINNING the WAR against GENETICS
    Email: pt [at] controlledlabs.com

  10. pu12en12g!

    I was unaware of the angiogenic effects. That is very interesting.
  11. Arrow Hijack...


    Quote Originally Posted by DR.D
    pu12en12g!

    I was unaware of the angiogenic effects. That is very interesting.
    Dr.D, I made a thread with your name on it. Please look a few threads below this one..
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