Some new 1,3-DMAA Studies - Safety + Efficiency

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    Some new 1,3-DMAA Studies - Safety + Efficiency


    I came across these recent DMAA studies this morning. I haven’t seen such comprehensive studies on safety and effectiveness on any 1,3 product or any mainstream product this well to date.

    This one is on OxyElite Pro effect on lipolysis and metabolic rate, which contains 1,3-DMAA:
    A Finished Dietary Supplement Stimulates Lipolysis and Metabolic Rate

    Another on OxyElite, touching on blood pressure and heart rate effects:
    Biochemical and Anthropometric Effects of a Weight Loss Dietary Supple

    This one is on OxyElite and Jack3d
    Hemodynamic and Hematologic Profile of Healthy Adults Ingesting Dietar

    Now, this doesnt mean all supplements containing the ingredients of OEP and Jack3d means they would give the same effects, because these are formulated products and the doses are unknown. An impressive effort by USPlabs to study both safety and efficiency.
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    sweet!
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    Wow, nice find.
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    This is a better 1,3-dimethylamylamine study:

    Effects of 1,3-Dimethylamylamine and Caffeine Alone or in Combination on Heart Rate and Blood Pressure in Healthy Men and Women

    Richard J. Bloomer, PhD; Innocence C. Harvey, BS; Tyler M. Farney, MS; Zach W. Bell, BS; and Robert E. Canale, MS

    The Physician and Sportsmedicine:
    Volume: 39 No.3
    The use of 1,3-dimethylamylamine (geranamine), alone and in combination with caffeine, is becoming widespread within the dietary supplement industry. To our knowledge, no data are available concerning the effects of oral geranamine intake on heart rate (HR) and blood pressure in individuals.

    Methods: Ten young healthy men and women ingested 1 of 5 conditions on different days using a double-blind, randomized, crossover design. The following were ingested after a 10-hour overnight fast: 250 mg caffeine (C), 50 mg geranamine (G 50 mg), 75 mg geranamine (G 75 mg), 250 mg caffeine + 50 mg geranamine (C + G 50 mg), and 250 mg caffeine + 75 mg geranamine (C + G 75 mg). Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and rate pressure product (RPP) were measured pre-ingestion and at 30, 60, 90, and 120 minutes post-ingestion. Plasma norepinephrine (NE) and epinephrine (EPI) were measured pre-ingestion and at 60 and 120 minutes post-ingestion.

    Results:
    Heart rate was unaffected by treatment, but blood pressure and RPP were higher with geranamine, generally in a dose-dependent manner. The peak percent change from pre-ingestion in SBP (~20%), DBP (~17%), and RPP (~9%) was noted with C + G 75 mg at 60 minutes post-ingestion. Plasma NE and EPI were relatively unaffected by treatment.

    Conclusion:
    We report for the first time that acute ingestion of 1,3-dimethylamylamine alone and in combination with caffeine results in an increase in SBP, DBP, and RPP without an increase in HR. The largest increase is observed at 60 minutes post-ingestion of C + G 75 mg. These changes cannot be explained by circulating NE and EPI.


    https://physsportsmed.org/doi/10.3810/psm.2011.09.1927
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    Quote Originally Posted by nattydisaster View Post
    I came across these recent DMAA studies this morning. I haven’t seen such comprehensive studies on safety and effectiveness on any 1,3 product or any mainstream product this well to date.

    This one is on OxyElite Pro effect on lipolysis and metabolic rate, which contains 1,3-DMAA:
    A Finished Dietary Supplement Stimulates Lipolysis and Metabolic Rate

    Another on OxyElite, touching on blood pressure and heart rate effects:
    Biochemical and Anthropometric Effects of a Weight Loss Dietary Supple

    This one is on OxyElite and Jack3d
    Hemodynamic and Hematologic Profile of Healthy Adults Ingesting Dietar

    Now, this doesnt mean all supplements containing the ingredients of OEP and Jack3d means they would give the same effects, because these are formulated products and the doses are unknown. An impressive effort by USPlabs to study both safety and efficiency.
    This barely hit Pubmed...great sign of a good researcher...your customer are lucky,
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    DALLAS – December 8, 2011Four new medical research studies published today and one more to come confirm that the best-selling supplements produced by USPlabs, Jack3d and OxyElite Pro, which contain DMAA, are safe and do not cause adverse health effects when used as directed, according to the research on DMAA conducted by a leading medical expert on nutritional supplements.

    The groundbreaking, peer-reviewed studies on the DMAA products were performed at an esteemed cardiorespiratory laboratory at a Division I, U.S. university by one of the nation’s leading and most respected experts on nutritional supplements.

    The release of these studies places both Jack3d and OxyElite Pro in the top 1% for volume of medical research performed on finished dietary supplements. The studies were undertaken in order to reiterate the safety of products containing DMAA through medical research and the results show that DMAA-containing products can be a safe and effective part of a healthy workout regimen.

    The results of the studies are as follows.

    Study #1: OxyElite Pro Acute Study
    In a randomized, double-blind and placebo-controlled trial with crossover, OxyElite Pro was shown to increase markers of lipolysis (fat breakdown) and energy expenditure (metabolic rate) in a group of six healthy men and six healthy women, all of whom were exercise-trained individuals. Specifically for the markers of lipolysis, glycerol was increased by an average of 29% and 65% over baseline in men and women, respectively, 120 minutes after ingesting two capsules of OxyElite Pro. Free fatty acids were increased by an average of 92% and 68% in men and women, respectively. Finally, energy expenditure was increased by an average of 9% and 24% in men and women, respectively.
    These data indicate that by increasing lipolysis and metabolic rate, the DMAA-containing OxyElite Pro may allow for reduced fat mass and weight loss.

    Link: http://www.la-press.com/a-finished-dietary-supplement-stimulates-lipolysis-and-metabolic-rate--article-a2945

    Study #2: OxyElite Pro Eight-Week Safety & Efficacy Study
    In a randomized, double-blind, placebo-controlled trial, OxyElite Pro was studied to see if it could improve body composition in healthy men and women over an eight-week period of use. A group of 32 exercise-trained men and women participated in the study. When comparing baseline values with those after eight weeks of use, subjects in the OxyElite Pro group were found to have decreased body weight, BMI, waist size, waist to hip ratio, total body fat percentage, fat mass and appetite.

    In addition to efficacy, safety of the DMAA-containing product was also assessed via hemodynamic and metabolic variables. While OxyElite did increase heart rate by an average of six beats per minute (comparable to the effect seen in some studies after the administration of caffeine dosages equivalent to 2 or 3 cups of coffee), no changes in blood pressure were noted when comparing the values seen at baseline to those after eight weeks of use. In addition, liver and kidney function were not affected as indicated by various blood borne markers. The supplement was well-tolerated and no serious adverse events were noted.

    In looking at the product’s efficacy, men experienced an average 1.16% reduction in body fat percentage while women experienced an average decrease of 0.8%. Men experienced a 1.24 inch reduction in their waist size from baseline, while women lost 0.78 inches. Men also lost 0.92 inches off their hips while the women's hip sizes didn't change, indicating an improvement of the waist-hip ratio.

    Men's fat mass decreased by 3.86 lb from baseline while women's fat mass decreased 1.9 lb. Men's body weight decreased by an average of 5.06 lb from baseline while women's decreased 3.36 lb.

    In addition, when subjects were asked to rate their appetite on a scale of 1-10 from baseline until week eight of the study, they reported an average decrease in appetite scores of approximately 24% after using OxyElite Pro.

    Overall, this eight-week study corroborated what the previous acute study indicated, which is that by increasing lipolysis and metabolic rate, OxyElite Pro is able to reduce fat mass in healthy men and women.
    Link: http://www.la-press.com/biochemical-and-anthropometric-effects-of-a-weight-loss-dietary-supple-article-a2946

    Study #3: Jack3d Two-Week Safety Study
    In an open-label, single-arm trial consisting of seven healthy men, each was instructed to consume the DMAA-containing Jack3d each day for two weeks. At the beginning and end of the study, blood pressure, heart rate and various indicators of renal and liver function were assessed. The study found that there were no statistically significant changes from baseline to the end of the study. Jack3d, which contains DMAA, was well tolerated and no serious adverse events were noted.

    In addition to these data, the hemodynamic response to acute ingestion was assessed as well for this DMAAproduct. Although small and transient changes in blood pressure were noted, these changes were consistent with changes seen after administration of the equivalent of 2-3 cups of coffee. Jack3d did not result in a statistically significant change in heart rate or blood pressure.

    Link: http://www.la-press.com/hemodynamic-and-hematologic-profile-of-healthy-adults-ingesting-dietar-article-a2947

    Study #4: OxyElite Pro Two-Week Safety Study

    In an open-label, single-arm trial consisting of four men and two women, subjects were instructed to consume OxyElite Pro each day for two weeks. At the beginning and end of the study, blood pressure, heart rate and various indicators of renal and liver function were assessed. The study found that there were no statistically significant changes from baseline to the end of the study. No serious adverse events were noted.

    In addition to these data, the hemodynamic response to acute ingestion was assessed as well. OxyElite Pro did not result in a statistically significant change in heart rate or diastolic pressure, but did cause a statistically significant change in systolic blood pressure; this increase was mild and transient and yet again, was similar to the increase seen in subjects ingesting an amount of caffeine equivalent to 2-3 cups of coffee.

    Link: http://www.la-press.com/hemodynamic-and-hematologic-profile-of-healthy-adults-ingesting-dietar-article-a2947

    Study #5: Jack3d Ten-Week Safety Study

    In addition, a ten-week safety study on the DMAA-containing Jack3d has been submitted for publication. This study evaluated heart rate, blood pressure and various measures of metabolic function (e.g., liver and kidney function) and found no changes from baseline to the end of the study. Jack3d was well tolerated and no adverse effects were noted.
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    Quote Originally Posted by USProduct-Edu View Post
    This barely hit Pubmed...great sign of a good researcher...your customer are lucky,
    I spend my saturdays doing fun things like researching
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    Damn...looks like I only came across 3 of 5. Ah well still not too shabby!
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    Quote Originally Posted by nattydisaster View Post
    I spend my saturdays doing fun things like researching
    Great for the consumer...
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    anyone mind postin a run down of the findings?
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    These studies are all nice and dandy, but I'm going to take a wild guess and say that users of OEP or Jack3d will be taking it for more than 2 weeks... So this 'safety' is purely academic.
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    Quote Originally Posted by trenbologna View Post
    These studies are all nice and dandy, but I'm going to take a wild guess and say that users of OEP or Jack3d will be taking it for more than 2 weeks... So this 'safety' is purely academic.
    There are 8 week oxy elite and 10 week jack3d safety studies as well. Just read a few post up haha
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    Quote Originally Posted by trenbologna View Post
    These studies are all nice and dandy, but I'm going to take a wild guess and say that users of OEP or Jack3d will be taking it for more than 2 weeks... So this 'safety' is purely academic.
    Exactly why we funded an 8 week and 10 week study..
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    Quote Originally Posted by SweetLou321 View Post
    There are 8 week oxy elite and 10 week jack3d safety studies as well. Just read a few post up haha
    University studies at that...these are a risk because the University will publish regardless of results.
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    Quote Originally Posted by tilldeath View Post
    anyone mind postin a run down of the findings?
    Post 6 has a synopsis..
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    Quote Originally Posted by USProduct-Edu View Post
    University studies at that...these are a risk because the University will publish regardless of results.
    This...most people don't realize the significance or reason university studies are so important
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    Isn't 1,3 banned? Aren't several companies taking it away from their sups? Endosurge, 1mr etc.. ?
    Studies or not, I would never touch it again..
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    Quote Originally Posted by AutoKal47 View Post
    Isn't 1,3 banned? Aren't several companies taking it away from their sups? Endosurge, 1mr etc.. ?
    Studies or not, I would never touch it again..
    Endosurge doesnt have 1,3 in it brother. Also i noticed the newer 1mr has no 1,3.
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    I am mobile so I am sure I am missing it. But what university sponsored these studies for USPlabs?[QUOTE="nattydisaster"]

    This...most people don't realize the significance or reason university studies are so important[/QUOTE
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    Quote Originally Posted by nattydisaster View Post
    This...most people don't realize the significance or reason university studies are so important
    ..But sometimes they are not
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    Quote Originally Posted by 3clipseGT View Post
    Endosurge doesnt have 1,3 in it brother. Also i noticed the newer 1mr has no 1,3.
    Sorry, it was PreSurge, my bad
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    Journal of Caffeine Research
    Effect of Caffeine and 1,3-Dimethylamylamine on Exercise Performance and Blood Markers of Lipolysis and Oxidative Stress in Trained Men and Women


    Background: Caffeine is one of the most widely used ergogenic aids worldwide. Recently, caffeine has been combined with 1,3-dimethylamylamine (1,3-D) in an attempt to improve exercise performance and related variables. We investigated the effect of caffeine and 1,3-D alone and in combination on exercise performance and blood markers of lipolysis and oxidative stress.

    Methods: Twelve exercise-trained subjects ingested placebo, caffeine (4 mg·kg−1), 1,3-D (1 mg·kg−1), or caffeine+ 1,3-D, 60 minutes before completing a 10 km run. Blood was collected before intake, immediately pre-exercise, and at 5 and 30 minutes postexercise. Samples were analyzed for glycerol, free fatty acids (FFAs), malondialdehyde, nitrate/nitrite, and trolox equivalent antioxidant capacity (TEAC).
    Results: Run time (minutes) was not different for placebo (52.55±1.96), caffeine (52.00±1.88), 1,3-D (52.02±1.86), or caffeine+ 1,3-D (52.46±1.94) (p>0.05). Glycerol and FFA were higher 5 and 30 minutes postexercise compared with pretreatment and pre-exercise (p<0.05). A condition effect was noted for glycerol (p=0.01), with higher values for 1,3-D compared with caffeine+ 1,3-D (p<0.05). A condition effect was noted for TEAC (p=0.0001), with higher values for placebo compared with caffeine and caffeine+ 1,3-D, and higher values for 1,3-D compared with caffeine (p<0.05). No other effects were noted for any measured variable (p>0.05).

    Conclusion: We report for the first time that caffeine+ 1,3D does not improve exercise performance as measured by run time. Isolated ingestion of 1,3-D results in the greatest increase in postexercise glycerol and FFA. Caffeine or 1,3-D alone or in combination does not differently affect oxidative stress biomarkers.

    Richard J. Bloomer, Cameron G. McCarthy, Tyler M. Farney, and Innocence C. Harvey. Journal of Caffeine Research. September 2011, 1(3): 169-177. doi:10.1089/jcr.2011.0019.
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    Quote Originally Posted by AutoKal47 View Post
    Sorry, it was PreSurge, my bad
    Np bro just wanted to clarify.
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