LCLT and androgen receptor sensitivity
- 06-07-2011, 11:06 PM
LCLT and androgen receptor sensitivity
LCLT has been touted as being able to increase androgen receptor sensitivity. Now this is a great thing in muscle cells, but not so hot in cells of other organs such as the prostate. I guess my question is, is the whole androgen receptor thing and LCLT specific to the muscle cell or is it a body wide thing? The last thing a guy needs is am increase in androgen sensitivity in the prostate...i don't plan on possible castration being part of my future. The only intranet access I have at the moment is on my phone so researching myself is a real pain. Any insight?
- 06-08-2011, 12:47 AM
A bigger question is AR sensitivity even beneficial?
When there are more androgens in the body, it products more ARs. Not sure the sensitivity increase would really do anything. It could though
06-08-2011, 10:51 AM
06-08-2011, 01:11 PM
Androgenic responses to resistance exercise: effects of feeding and L-carnitine.
Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM.
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269-1110, USA. William.Kraemer@uconn.edu
* Med Sci Sports Exerc. 2006 Oct;38(10):1861.
PURPOSE: The purpose of this investigation was to determine the effects of 3 wk of L-carnitine L-tartrate (LCLT) supplementation and post-resistance-exercise (RE) feeding on hormonal and androgen receptor (AR) responses.
METHODS: Ten resistance-trained men (mean+/-SD: age, 22+/-1 yr; mass, 86.3+/-15.3 kg; height, 181+/-11 cm) supplemented with LCLT (equivalent to 2 g of L-carnitine per day) or placebo (PL) for 21 d, provided muscle biopsies for AR determinations, then performed two RE protocols: one followed by water intake, and one followed by feeding (8 kcal.kg body mass, consisting of 56% carbohydrate, 16% protein, and 28% fat). RE protocols were randomized and included serial blood draws and a 1-h post-RE biopsy. After a 7-d washout period, subjects crossed over, and all experimental procedures were repeated.
RESULTS: LCLT supplementation upregulated (P<0.05) preexercise AR content compared with PL (12.9+/-5.9 vs 11.2+/-4.0 au, respectively). RE increased (P<0.05) AR content compared with pre-RE values in the PL trial only. Post-RE feeding significantly increased AR content compared with baseline and water trials for both LCLT and PL. Serum total testosterone concentrations were suppressed (P<0.05) during feeding trials with respect to corresponding water and pre-RE values. Luteinizing hormone demonstrated subtle, yet significant changes in response to feeding and LCLT.
CONCLUSION: In summary, these data demonstrated that: 1) feeding after RE increased AR content, which may result in increased testosterone uptake, and thus enhanced luteinizing hormone secretion via feedback mechanisms; and 2) LCLT supplementation upregulated AR content, which may promote recovery from RE.
06-08-2011, 01:16 PM
l carnitine tartrate
bumped thread since Andrew732 said "The good thing about it, is it does NOT aggrevate the AR receptors within the prostate which makes it quite the catch."
Might want to send him a PM and ask if he knows the study that documented this.
06-08-2011, 01:48 PM
06-08-2011, 02:04 PM
06-08-2011, 02:16 PM
06-08-2011, 02:21 PM
06-08-2011, 02:28 PM
06-08-2011, 02:35 PM
06-08-2011, 02:56 PM
Study is old news. But they were measuring skeletal muscle AR content. Not prostate. So OP's question is still unknown. I know there is nothing on humans and LCLT/Prostate interactions but I believe there is some more rat research out there, but I cannot recall if it was relevant. University of Stirling in Scotland has one I think.
Btw in that study they made them skwat A LOT!!!
06-08-2011, 03:03 PM
06-08-2011, 03:47 PM
06-08-2011, 05:53 PM
06-08-2011, 05:59 PM
06-08-2011, 06:00 PM
06-08-2011, 06:13 PM
06-08-2011, 07:29 PM
06-08-2011, 08:13 PM
06-08-2011, 08:43 PM
Not sure what all this secrecy is about a relevant study. Why doesn't somebody who has it jist post it up or link it? I think it would be intersting and pertinent to the op's question if it is as it is claimed.
Serious Nutrition Solutions rep
06-08-2011, 10:58 PM
06-08-2011, 11:11 PM
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