D Aspartic Acid & Negative side effects
- 03-10-2011, 03:29 PM
- 03-10-2011, 05:08 PM
I have used it 3 times so far. Once for a month bulk, once with pills and currently bulk 3 grams a day. I have never noticed any adverse effects. I do notice higher testosterone like sides(positive). I enjoy it and will keep using it.
03-10-2011, 05:09 PM
03-10-2011, 05:35 PM
03-10-2011, 05:35 PM
03-10-2011, 05:43 PM
am i the only one who didn't get jack from daa.....i didn't feel better, i didn't see any bb gains, balls didn't swell....the best part of the stuff was it tasted awesome for a bulk supplement
03-10-2011, 06:22 PM
Can I just get some clarification also here.. Who said that the test boosting activity of DAA was due to its conversion to NMDA and it's activity on that receptor? Or is that theorized? I looked through the whole test and didn't see that information implied anywhere.. Although it was stated that some was converted to NMDA..
Here we demonstrated that D-aspartic acid, which occurs as a physiological compound in the mammalian pituitary and testis, has a role in the regulation of the release and synthesis of LH and testosterone. In humans and rats, sodium D-Asp treatment enhances the release of LH and testosterone. The experiments that we carried out on rats have permitted us to understand that this amino acid regulates the synthesis of LH and testosterone in the pituitary and the testis respectively. This action is mediated in the pituitary by cGMP and in the testis by cAMP, which act as the second messengers in the signal transduction in the pituitary and testes respectively. The pituitary and testis possesses a D-Aspartate racemase, which provides the necessary production of D-Asp.
03-10-2011, 06:28 PM
I am pretty sure this shows that DAA has NMDA activity on its own..
Finally, D-Asp (100-1000 μM) stimulated PRL secretion and this effect was reduced by a NMDA receptor antagonist.
03-10-2011, 06:37 PM
03-10-2011, 07:12 PM
03-10-2011, 07:46 PM
i had great bb'ing effect from daa, strength and appetite both went way up-less than when i started test cyp but in the ballpark. difference was libido tanked.
WELL DONE IS BETTER THAN WELL SAID
03-10-2011, 08:27 PM
The benefits of early acceptence are to obtain the edge from a new product, the risk are the limited research on long-term use.
While your questions are valid, they're expensive to verify.
I would imagine test levels increase slowly, then rapidly, then begin to level off, and slowly start to wain with continued usage. This would require a lot of really expensive blood tests. Usually in doing a clinical study, the results are compromised by limited funds. There's an order of operations these tend to follow. You can see the same trend with creatine monohydrate in the 90's. First it's a matter of determining if the product does anything. When this is accomplished, then things progress to determine long-term use.
03-10-2011, 08:52 PM
03-10-2011, 09:04 PM
03-10-2011, 09:14 PM
Well I was planning on running DAA in my summer cut, very happy I found this thread the knowledge dropped has been awesome, now I will not be running DAA, sucks too because it works but I'm not wanting to mess with my brain, its already unstable enough
03-10-2011, 10:15 PM
My guess is that the natural formation from the L-isomer isn't all too significant. Too pick up the slack, you probably have a high receptor density, and thus the capacity for more more activation through external DAA supplementing.
03-10-2011, 10:17 PM
03-10-2011, 10:17 PM
03-10-2011, 11:36 PM
I started getting really bad anxiety on DAA and I've never had it before.. I've since stopped but am still getting it, but noticeably less often.. I don't suggest DAA is solely to blame for this, however it is interesting that it's declined since I stopped taking it.
03-11-2011, 01:51 AM
So to sum up what I've read thus far. DAA has been shown to increase test in in vivo studies, but nobody can produce a single study showing this excitotoxicity that some are stating as "fact." Please, if you have a study, post it, otherwise that is worse than bro science...it's bad science.
03-11-2011, 01:58 AM
03-11-2011, 10:03 AM
The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.
03-11-2011, 10:18 AM
03-11-2011, 10:19 AM
03-11-2011, 10:25 AM
I've run DAA on 3 seperate occasions. I've used bulk from NP & TCF-1. Minimum run was 2 weeks, max was a month. Each time I've noticed the following:
-Better workouts & recovery
-More of an "alpha male" mentality when working out
-sleep wasn't as sound or as good as it normally is
-bloating. I seem to hold water when taking it
-mood is off just a bit
Does it work? I think it does raise "T" levels for me. I do get some acne on my back but I didn't experience any crazy rise in libido though.
03-11-2011, 11:01 AM
Your third citation shows that DAA is an agonist of NMDA, BUT never once shows it to be excitotoxic. Just because something is an agonist, does not make it excitotoxic! DAA is a precursor to the biosynthesis of NMDA, but even that does not mean it will lead to excitoxicity. If any compound in use today has been shown to have excitotoxic properties, it is nitric oxide, but even that is not always the case and the mass amounts of arginine you would need to ingest to actually make this possible across the blood brain barrier make it a moot point.
You're talking about endogenous neurotransmitters in relation to an event like excitotoxicty which requires a unique set of circumstances to occur. The simple act of increasing neurotransmission will not cause excitotoxicity.
I'm not trying to be a jerk, just trying to keep you honest because I keep seeing this said with no evidence. So I will repeat my challenge. Can anybody show a single in vivo study where DAA causes excitotoxicity?
03-11-2011, 11:06 AM
03-11-2011, 11:19 AM
All the science leads to what has been stated, being a neuroscientist I would assume you would provide a word of caution given the facts presented. As I have yet to see you provide in vivo studies proving to the contrary I can only assume you have some vested interest, even after the aforementioned statement. In our PM you even agreed with me about DAA converting to N-Methyl-D-Aspartate, but then gave a "Yes, but" that something that is a known excitotoxin is no long an excitotoxin in this instance?!
As a neuroscientiest I would expect you to err on the side of caution. Seems incongruous to your self proclaimed profession.
The Historic PES Legend
03-11-2011, 11:29 AM
This is real easy and let me talk slow so even my "retard" brain can keep up. Can anybody show one single study where DAA causes excitotoxicity?
I'm asking for my own personal knowledge and don't care if the study was performed in humans, rats or trees. Just one!
03-11-2011, 11:34 AM
Ive bben taking 4.5 g a day for 9 days with no sides except some diarhea 2 days. Not noticing strength increases yet. I have anxiety and havent felt different.
Similar Forum Threads
- By Guest in forum Company PromotionsReplies: 48Last Post: 06-06-2012, 12:51 PM
- By packers6211 in forum SupplementsReplies: 8Last Post: 12-19-2010, 08:36 AM
- By MAxximal in forum SupplementsReplies: 1Last Post: 11-08-2010, 12:32 PM
- By MAxximal in forum SupplementsReplies: 0Last Post: 08-04-2010, 01:45 PM
- By Graham in forum SupplementsReplies: 1Last Post: 10-30-2008, 03:43 AM