D Aspartic Acid & Negative side effects

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  1. What is everyone's thoughts with Agmatine then? If I recall correctly Agmatine is a NMDA antagonist right? So basically it's doing the opposite of what DAA is doing. I can't imagine that's a good thing either.


  2. I have used it 3 times so far. Once for a month bulk, once with pills and currently bulk 3 grams a day. I have never noticed any adverse effects. I do notice higher testosterone like sides(positive). I enjoy it and will keep using it.
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  3. Quote Originally Posted by Mrodz View Post
    I got the e-mail rolling along when I read Judo's post over at stakedcops Log and I have an answer now, gonna let u guys have it out on that one, here goes

    "Questions 1-3

    These cannot be quantitatively answered because there is no negative control, and in order to make even qualitative inferences, one would need to take a biopsy of the brain or testicles. (be my guest, somebody might pay you for the study)

    As far as I can tell, DAA almost exclusively promotes the release of GnRH (Gonadotropin-releasing hormone) which is responsible for LH (Luteinizing-hormone) production which is THEN responsible for steroidogenesis. With all these steps and with all the communication that has to occur, I doubt anything will get accumulated to astronomical levels unless somebody has a medical condition.


    Questions 4 and 5

    If you are talking about calcium influx into a neuron then the limiting factor will become glycine, the ion channel is BOTH ligand and voltage dependent.
    NMDA would have to bind AND glycine for calcium to enter the neuron, so even if there is an excess of NDMA it won't effect calcium ion influx into the cell unless there is also an excess of glycine as well. Glycine does not act exclusively as a neurotransmitter/hormone like DAA does so it will not necessarily accumulate in the brain more if you eat a ton of glycine.

    Secondly, the channel is voltage dependent, so if the charge inside the neuron reaches a certain point due to calcium buildup there will be a repulsion effect (think of sticking the same pole of two magnets together)


    I will say this.

    Since DAA is not active directly and must be metabolized, the body's negative feedback system will likely kick in before anything accumulates to dangerous levels.

    I hope this covers the information you wanted to cover."



    I have been sitting on my butt reading and reading for quite awhile on all sorts of aspartame and glutamate and what nots (Dolly Parton's movie 9-5 playing n the background :/ .....twice) and i havent been thrown off of having my two packets of sweetener in the morning yet.

    I have found on my own research, (even researching in Italian) a lot of evidence that back up the claims on the increased production of testosterone and it is used in Italy for fertility treatments. The truth I've seen is there seems to be a lot of info out there that verifies it really does what it's being marketed for in the supps industry and not much research on the negative effects although it does seem to be riding on the research done on aspartame.
    this is me, I'm like u guys, I do bodywork not a scientist.

    Now I've always had some ideas on the "increase" in neurological disorders (the quotation isn't because I don't believe it, it's because I haven't read up on like per capita or anything, so I'm not sure on it, or at least I haven't been convinced yet either way, but i will read up...anyway)
    alleged causes:
    plastic bowls, pill containers and water bottles etc... (basically a lot of plastic stuff)
    tampons
    fluorescent lights
    wireless devices
    *sunblock may cause chemical cancer

    ok any way lots of stuff.....
    Now I have no idea which way this goes in terms of the current discussion LOL but u know it's info that's out there.

    I'm gonna stay away from google for awhile O.o

    well I'm sure more questions will pop up so lets keep reading
    So basically we still don't know if it is safe or not.

    Edit: Repped for your work smallfry.

  4. Quote Originally Posted by TheLastRonin View Post
    I have used it 3 times so far. Once for a month bulk, once with pills and currently bulk 3 grams a day. I have never noticed any adverse effects. I do notice higher testosterone like sides(positive). I enjoy it and will keep using it.
    About 3 weeks in on PCT. About the same results.

  5. Quote Originally Posted by thesinner View Post
    All of this talk about activating the NMDA receptor has me thinking of MSG.

    Are those having sides also prone to trouble with gluten, chinese food, top ramen, or gas station beef jerkey.
    Not here.. I have never had a problem with anything I eat or drink.. Nor some very questionable substances I have taken.. Although 10 days on DAA made me feel like I had been binging all night..

  6. am i the only one who didn't get jack from daa.....i didn't feel better, i didn't see any bb gains, balls didn't swell....the best part of the stuff was it tasted awesome for a bulk supplement

  7. Can I just get some clarification also here.. Who said that the test boosting activity of DAA was due to its conversion to NMDA and it's activity on that receptor? Or is that theorized? I looked through the whole test and didn't see that information implied anywhere.. Although it was stated that some was converted to NMDA..

    http://www.rbej.com/content/7/1/120

    Here we demonstrated that D-aspartic acid, which occurs as a physiological compound in the mammalian pituitary and testis, has a role in the regulation of the release and synthesis of LH and testosterone. In humans and rats, sodium D-Asp treatment enhances the release of LH and testosterone. The experiments that we carried out on rats have permitted us to understand that this amino acid regulates the synthesis of LH and testosterone in the pituitary and the testis respectively. This action is mediated in the pituitary by cGMP and in the testis by cAMP, which act as the second messengers in the signal transduction in the pituitary and testes respectively. The pituitary and testis possesses a D-Aspartate racemase, which provides the necessary production of D-Asp.

  8. I am pretty sure this shows that DAA has NMDA activity on its own..

    Finally, D-Asp (100-1000 μM) stimulated PRL secretion and this effect was reduced by a NMDA receptor antagonist.

    https://www.thieme-connect.com/ejour...5/s-2002-29092

  9. The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.

    http://www.ncbi.nlm.nih.gov/pubmed/15806114

  10. Quote Originally Posted by Young Gotti View Post
    am i the only one who didn't get jack from daa.....i didn't feel better, i didn't see any bb gains, balls didn't swell....the best part of the stuff was it tasted awesome for a bulk supplement
    Yeah, aspartic acids have a sweet taste.

    Studies are showing that it increases testosterone by about a third. What sort of gains were you expecting from daa?
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  11. Quote Originally Posted by thesinner View Post
    Yeah, aspartic acids have a sweet taste.

    Studies are showing that it increases testosterone by about a third. What sort of gains were you expecting from daa?
    at what dose and after how long. also how long will this last after stopping, plus will it put you in the negative after. the study i saw was based on 3 gm for 12 days, will higher dose and longer use increase or decrease effect. mostly i am concerned about what happens after taking-will it continue to keep test level raised for a significant amount of time, or will test levels drop to lower than before using level.

    i had great bb'ing effect from daa, strength and appetite both went way up-less than when i started test cyp but in the ballpark. difference was libido tanked.
    WELL DONE IS BETTER THAN WELL SAID

  12. Quote Originally Posted by thebigt View Post
    at what dose and after how long. also how long will this last after stopping, plus will it put you in the negative after. the study i saw was based on 3 gm for 12 days, will higher dose and longer use increase or decrease effect. mostly i am concerned about what happens after taking-will it continue to keep test level raised for a significant amount of time, or will test levels drop to lower than before using level.

    i had great bb'ing effect from daa, strength and appetite both went way up-less than when i started test cyp but in the ballpark. difference was libido tanked.
    Now we're getting into the complexities of new product development.

    The benefits of early acceptence are to obtain the edge from a new product, the risk are the limited research on long-term use.

    While your questions are valid, they're expensive to verify.

    I would imagine test levels increase slowly, then rapidly, then begin to level off, and slowly start to wain with continued usage. This would require a lot of really expensive blood tests. Usually in doing a clinical study, the results are compromised by limited funds. There's an order of operations these tend to follow. You can see the same trend with creatine monohydrate in the 90's. First it's a matter of determining if the product does anything. When this is accomplished, then things progress to determine long-term use.

  13. Quote Originally Posted by thesinner View Post
    Now we're getting into the complexities of new product development.

    The benefits of early acceptence are to obtain the edge from a new product, the risk are the limited research on long-term use.

    While your questions are valid, they're expensive to verify.

    I would imagine test levels increase slowly, then rapidly, then begin to level off, and slowly start to wain with continued usage. This would require a lot of really expensive blood tests. Usually in doing a clinical study, the results are compromised by limited funds. There's an order of operations these tend to follow. You can see the same trend with creatine monohydrate in the 90's. First it's a matter of determining if the product does anything. When this is accomplished, then things progress to determine long-term use.
    my biggest concern is does test levels fall off the chart after using. lol-do you need a pct for daa?
    WELL DONE IS BETTER THAN WELL SAID

  14. Quote Originally Posted by thebigt View Post
    my biggest concern is does test levels fall off the chart after using. lol-do you need a pct for daa?
    If I recall grambo had bloods and said his test levels were normal after use. I'm not 100% sure but I was using 6 grams for a month and stopped once I read all the **** about NMDA but I kept taking my 2 erase. Can't be sure without bloods but my lady poker works fine still. I miss the every lasting sexual desire daa gave me... I still have a huge appetite for woman but man I was unreal while I daa!!


  15. Well I was planning on running DAA in my summer cut, very happy I found this thread the knowledge dropped has been awesome, now I will not be running DAA, sucks too because it works but I'm not wanting to mess with my brain, its already unstable enough

  16. Quote Originally Posted by thebigt View Post
    my biggest concern is does test levels fall off the chart after using. lol-do you need a pct for daa?
    The mechanism seems a bit indirect to cause significant negative feedback on a single outlet. When feedback happens over so many iterations, it takes a long time for the signal to get back to the source, and by that point it's usually pretty muffled. Kind of like when you were 6 and played the game "telephone".

    My guess is that the natural formation from the L-isomer isn't all too significant. Too pick up the slack, you probably have a high receptor density, and thus the capacity for more more activation through external DAA supplementing.

  17. Quote Originally Posted by thesinner View Post
    The mechanism seems a bit indirect to cause significant negative feedback on a single outlet. When feedback happens over so many iterations, it takes a long time for the signal to get back to the source, and by that point it's usually pretty muffled. Kind of like when you were 6 and played the game "telephone".

    My guess is that the natural formation from the L-isomer isn't all too significant. Too pick up the slack, you probably have a high receptor density, and thus the capacity for more more activation through external DAA supplementing.
    thanks...i think.
    WELL DONE IS BETTER THAN WELL SAID

  18. Quote Originally Posted by bubsnt3 View Post
    Not here.. I have never had a problem with anything I eat or drink.. Nor some very questionable substances I have taken.. Although 10 days on DAA made me feel like I had been binging all night..
    In all fairness, on a molar basis, 3g of DAA is equal to 3.8g of MSG.

    I'm not sure what that converts to in terms of packages of Top Ramen.

  19. I started getting really bad anxiety on DAA and I've never had it before.. I've since stopped but am still getting it, but noticeably less often.. I don't suggest DAA is solely to blame for this, however it is interesting that it's declined since I stopped taking it.

  20. So to sum up what I've read thus far. DAA has been shown to increase test in in vivo studies, but nobody can produce a single study showing this excitotoxicity that some are stating as "fact." Please, if you have a study, post it, otherwise that is worse than bro science...it's bad science.

  21. Quote Originally Posted by CobbledPath View Post
    I started getting really bad anxiety on DAA and I've never had it before.. I've since stopped but am still getting it, but noticeably less often.. I don't suggest DAA is solely to blame for this, however it is interesting that it's declined since I stopped taking it.
    Anxiety can indeed be caused by activation of the NMDA receptor, which is why supplementing with Magnesium (which blocks the channel) can help aleviate anxiety symptoms. Of course, using DAA and Mg together would defeat the purpose of each, so if you're having anxiety issues, I wouldn't use DAA.

  22. Quote Originally Posted by Aleksandar37 View Post
    So to sum up what I've read thus far. DAA has been shown to increase test in in vivo studies, but nobody can produce a single study showing this excitotoxicity that some are stating as "fact." Please, if you have a study, post it, otherwise that is worse than bro science...it's bad science.
    It is actually good science. No studies have been performed for the safety in humans.. DAA is a PROVEN EXITOTOXIN with agonist activity at the NMDA receptor.. And NMDA toxicity is not someones theory but proven science.. You are saying to ignore both anecdotal reports and available scientific literature because it is not "fact." That is rediculous when this substance has never been tested for it's toxicity in humans.. That is like saying taking the proline analog that was in Slim Xtreme is safe because noone has proof that the specific proline analog is neorotoxic.. Although 2DPMP is and they are as close as two sides of the same coin.. If you are basing your faith in the studies or information that supplement companies produce you are a retard.

    http://www.ncbi.nlm.nih.gov/pubmed/11738498
    http://en.wikipedia.org/wiki/Excitotoxicity

    The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.

    http://www.ncbi.nlm.nih.gov/pubmed/15806114

  23. Quote Originally Posted by bubsnt3 View Post
    It is actually good science. No studies have been performed for the safety in humans.. DAA is a PROVEN EXITOTOXIN with agonist activity at the NMDA receptor.. And NMDA toxicity is not someones theory but proven science.. You are saying to ignore both anecdotal reports and available scientific literature because it is not "fact." That is rediculous when this substance has never been tested for it's toxicity in humans.. That is like saying taking the proline analog that was in Slim Xtreme is safe because noone has proof that the specific proline analog is neorotoxic.. Although 2DPMP is and they are as close as two sides of the same coin.. If you are basing your faith in the studies or information that supplement companies produce you are a retard.

    http://www.ncbi.nlm.nih.gov/pubmed/11738498
    http://en.wikipedia.org/wiki/Excitotoxicity

    The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.

    http://www.ncbi.nlm.nih.gov/pubmed/15806114
    Beat me to it. DAA also converts to N-Methyl-D-Asparate through SAMe methyl-transferese.
    The Historic PES Legend

  24. Quote Originally Posted by thesinner View Post
    Yeah, aspartic acids have a sweet taste.

    Studies are showing that it increases testosterone by about a third. What sort of gains were you expecting from daa?
    just expected to see some of the stuff i was reading in reviews.....alpha male feeling, overall well being increased, leaning and hardening, possibly some strength gains

  25. I've run DAA on 3 seperate occasions. I've used bulk from NP & TCF-1. Minimum run was 2 weeks, max was a month. Each time I've noticed the following:

    Positives:
    -Better workouts & recovery
    -More of an "alpha male" mentality when working out

    Negatives
    -dull headache
    -sleep wasn't as sound or as good as it normally is
    -bloating. I seem to hold water when taking it
    -mood is off just a bit

    Does it work? I think it does raise "T" levels for me. I do get some acne on my back but I didn't experience any crazy rise in libido though.

  26. Quote Originally Posted by bubsnt3 View Post
    It is actually good science. No studies have been performed for the safety in humans.. DAA is a PROVEN EXITOTOXIN with agonist activity at the NMDA receptor.. And NMDA toxicity is not someones theory but proven science.. You are saying to ignore both anecdotal reports and available scientific literature because it is not "fact." That is rediculous when this substance has never been tested for it's toxicity in humans.. That is like saying taking the proline analog that was in Slim Xtreme is safe because noone has proof that the specific proline analog is neorotoxic.. Although 2DPMP is and they are as close as two sides of the same coin.. If you are basing your faith in the studies or information that supplement companies produce you are a retard.

    The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.
    Your first citation is a study in the slice which they intentionally use a large amount of NMDA, NOT DAA to lesion the cells in their study. This is common practice and is not proof in any way, shape or form. The second citation is wikipedia...shooting that one down is too easy.

    Your third citation shows that DAA is an agonist of NMDA, BUT never once shows it to be excitotoxic. Just because something is an agonist, does not make it excitotoxic! DAA is a precursor to the biosynthesis of NMDA, but even that does not mean it will lead to excitoxicity. If any compound in use today has been shown to have excitotoxic properties, it is nitric oxide, but even that is not always the case and the mass amounts of arginine you would need to ingest to actually make this possible across the blood brain barrier make it a moot point.

    You're talking about endogenous neurotransmitters in relation to an event like excitotoxicty which requires a unique set of circumstances to occur. The simple act of increasing neurotransmission will not cause excitotoxicity.

    I'm not trying to be a jerk, just trying to keep you honest because I keep seeing this said with no evidence. So I will repeat my challenge. Can anybody show a single in vivo study where DAA causes excitotoxicity?

  27. Quote Originally Posted by bubsnt3 View Post
    If you are basing your faith in the studies or information that supplement companies produce you are a retard.
    And just to address this direct attack on me. I'm asking an honest question as somebody that has a PhD in neuroscience. I do not work for or rep any company nor do I believe anything that anybody says without seeing studies that back it up. So I find your accusation of me being a "retard" to be quite funny and await you actually addressing my question.

  28. Quote Originally Posted by Aleksandar37 View Post
    And just to address this direct attack on me. I'm asking an honest question as somebody that has a PhD in neuroscience. I do not work for or rep any company nor do I believe anything that anybody says without seeing studies that back it up. So I find your accusation of me being a "retard" to be quite funny and await you actually addressing my question.
    I do not personally care for attacks as such, but please spare us your E-Resume.

    All the science leads to what has been stated, being a neuroscientist I would assume you would provide a word of caution given the facts presented. As I have yet to see you provide in vivo studies proving to the contrary I can only assume you have some vested interest, even after the aforementioned statement. In our PM you even agreed with me about DAA converting to N-Methyl-D-Aspartate, but then gave a "Yes, but" that something that is a known excitotoxin is no long an excitotoxin in this instance?!

    As a neuroscientiest I would expect you to err on the side of caution. Seems incongruous to your self proclaimed profession.
    The Historic PES Legend

  29. Quote Originally Posted by DAdams91982 View Post
    I do not personally care for attacks as such, but please spare us your E-Resume.

    All the science leads to what has been stated, being a neuroscientist I would assume you would provide a word of caution given the facts presented. As I have yet to see you provide in vivo studies proving to the contrary I can only assume you have some vested interest, even after the aforementioned statement. In our PM you even agreed with me about DAA converting to N-Methyl-D-Aspartate, but then gave a "Yes, but" that something that is a known excitotoxin is no long an excitotoxin in this instance?!

    As a neuroscientiest I would expect you to err on the side of caution. Seems incongruous to your self proclaimed profession.
    I have no vested interest and will not be pulled into a name calling match as you have now jumped on board with that one. I have NOT said that DAA is completely safe and everybody should use it.

    This is real easy and let me talk slow so even my "retard" brain can keep up. Can anybody show one single study where DAA causes excitotoxicity?

    I'm asking for my own personal knowledge and don't care if the study was performed in humans, rats or trees. Just one!

  30. Ive bben taking 4.5 g a day for 9 days with no sides except some diarhea 2 days. Not noticing strength increases yet. I have anxiety and havent felt different.
  

  
 

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