D Aspartic Acid & Negative side effects
- 03-08-2011, 05:24 PM
- 03-08-2011, 05:27 PM
- 03-08-2011, 05:30 PM
There are quite a few people taking DAA products, my point is to try to advise them on how to do it in a fashion that may help to minimize some of the sides that some individuals enounterDirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals
03-08-2011, 05:31 PM
03-08-2011, 05:32 PM
03-08-2011, 05:34 PM
03-08-2011, 05:36 PM
ive taken it for 30 days straight twice and while I did notice a slight libido boost, something like Sustain Alpha definitely blew it out of the water. plus considering the possible prolactin issues etc its not worth it IMO
BJJ = life
03-09-2011, 06:40 PM
To add to this discussion on DAA
NOTE: The below copied text is from another thread where the subject of DAA came up and I was given this link (http://en.wikipedia.org/wiki/Excitotoxicity) and that is where I am getting the information (along with a quick google search). NOTE: I am in NO way a research scientist or anything along those lines.. this is just my interpurtation from what I have read. I am not posting this to say I am right or anything as I know I very well may be wrong with my interpetition. I am just adding to the discussion and seeing if someone can help clarify it some more and further elaborate
"The only good is knowledge and the only evil is ignorance." - Socrates
03-09-2011, 06:54 PM
03-09-2011, 07:27 PM
For real. I've been lurking in this thread for a few days........
Then I read the breakdown from JudoJosh earlier and it started to make sense.
These are great questions that I would love to see answered (IMO)
03-09-2011, 08:14 PM
I belive DAA is a NMDA agonist as well.. Through the methyl-tranferase reaction some is converted to N-Methyl-D-Aspartate which is far more potent but I am pretty sure DAA is an agonist on it's own..
Good info though and good questions.
03-10-2011, 05:07 AM
03-10-2011, 07:16 AM
03-10-2011, 07:38 AM
Anybody figure out a way to tolerate GI sides effectively? About an hour after I take it without fail I have like ridiculous diarrhea=no good at my job. I'm clenching my asscheeks to hold it in.
03-10-2011, 07:54 AM
I had stomach pain and diarrhoea, tried splitting the dosage, taking with food etc. After three days or so I stopped usage and sold it.
In retrospect the possible risks on the brain are not worth it for me and I wouldn't take it again and avoid formulas with it in.
03-10-2011, 08:05 AM
03-10-2011, 09:34 AM
JJ - Your questions are valid questions, and ones you will not find a qualified answer for. You will find research on performance of DAA, but safety is lacking. As I said, we are elevating a known exitotoxin with the the severe ability to damage myelin. You will not find safety thresholds because everyone is different, especially with regard to brain chemistry. The problem with everyone's acute idea of saying "I was fine after two months of use" means nothing because the damage wouldn't show up till later in life with brain related disease. Alzheimers? Dimentia? Parkinsons? Who knows. But what I do know is all of these neural diseases are on the rise at a rapid pace, all that with the prior generations not touching stuff like this.
Everyone is free to do as they wish, it is your body.
The Historic PES Legend
03-10-2011, 11:29 AM
All of this talk about activating the NMDA receptor has me thinking of MSG.
Are those having sides also prone to trouble with gluten, chinese food, top ramen, or gas station beef jerkey.
03-10-2011, 11:49 AM
MSG and Aspartame/Aspartic Acid etc is an interesting comparison.
This is definitely not scientific but offers another point of view. I found it interesting if for no other reason than to play devil's advocate.
03-10-2011, 02:28 PM
There are quite a few people taking DAA products, my point is to try to advise them on how to do it in a fashion that may help to minimize some of the sides that some individuals encounter
I got the e-mail rolling along when I read Judo's post over at stakedcops Log and I have an answer now, gonna let u guys have it out on that one, here goes
These cannot be quantitatively answered because there is no negative control, and in order to make even qualitative inferences, one would need to take a biopsy of the brain or testicles. (be my guest, somebody might pay you for the study)
As far as I can tell, DAA almost exclusively promotes the release of GnRH (Gonadotropin-releasing hormone) which is responsible for LH (Luteinizing-hormone) production which is THEN responsible for steroidogenesis. With all these steps and with all the communication that has to occur, I doubt anything will get accumulated to astronomical levels unless somebody has a medical condition.
Questions 4 and 5
If you are talking about calcium influx into a neuron then the limiting factor will become glycine, the ion channel is BOTH ligand and voltage dependent.
NMDA would have to bind AND glycine for calcium to enter the neuron, so even if there is an excess of NDMA it won't effect calcium ion influx into the cell unless there is also an excess of glycine as well. Glycine does not act exclusively as a neurotransmitter/hormone like DAA does so it will not necessarily accumulate in the brain more if you eat a ton of glycine.
Secondly, the channel is voltage dependent, so if the charge inside the neuron reaches a certain point due to calcium buildup there will be a repulsion effect (think of sticking the same pole of two magnets together)
I will say this.
Since DAA is not active directly and must be metabolized, the body's negative feedback system will likely kick in before anything accumulates to dangerous levels.
I hope this covers the information you wanted to cover."
I have been sitting on my butt reading and reading for quite awhile on all sorts of aspartame and glutamate and what nots (Dolly Parton's movie 9-5 playing n the background :/ .....twice) and i havent been thrown off of having my two packets of sweetener in the morning yet.
I have found on my own research, (even researching in Italian) a lot of evidence that back up the claims on the increased production of testosterone and it is used in Italy for fertility treatments. The truth I've seen is there seems to be a lot of info out there that verifies it really does what it's being marketed for in the supps industry and not much research on the negative effects although it does seem to be riding on the research done on aspartame.
this is me, I'm like u guys, I do bodywork not a scientist.
Now I've always had some ideas on the "increase" in neurological disorders (the quotation isn't because I don't believe it, it's because I haven't read up on like per capita or anything, so I'm not sure on it, or at least I haven't been convinced yet either way, but i will read up...anyway)
plastic bowls, pill containers and water bottles etc... (basically a lot of plastic stuff)
*sunblock may cause chemical cancer
ok any way lots of stuff.....
Now I have no idea which way this goes in terms of the current discussion LOL but u know it's info that's out there.
I'm gonna stay away from google for awhile O.o
well I'm sure more questions will pop up so lets keep reading
03-10-2011, 02:29 PM
What is everyone's thoughts with Agmatine then? If I recall correctly Agmatine is a NMDA antagonist right? So basically it's doing the opposite of what DAA is doing. I can't imagine that's a good thing either.
03-10-2011, 04:08 PM
I have used it 3 times so far. Once for a month bulk, once with pills and currently bulk 3 grams a day. I have never noticed any adverse effects. I do notice higher testosterone like sides(positive). I enjoy it and will keep using it.
03-10-2011, 04:09 PM
03-10-2011, 04:35 PM
03-10-2011, 04:35 PM
03-10-2011, 04:43 PM
am i the only one who didn't get jack from daa.....i didn't feel better, i didn't see any bb gains, balls didn't swell....the best part of the stuff was it tasted awesome for a bulk supplement
03-10-2011, 05:22 PM
Can I just get some clarification also here.. Who said that the test boosting activity of DAA was due to its conversion to NMDA and it's activity on that receptor? Or is that theorized? I looked through the whole test and didn't see that information implied anywhere.. Although it was stated that some was converted to NMDA..
Here we demonstrated that D-aspartic acid, which occurs as a physiological compound in the mammalian pituitary and testis, has a role in the regulation of the release and synthesis of LH and testosterone. In humans and rats, sodium D-Asp treatment enhances the release of LH and testosterone. The experiments that we carried out on rats have permitted us to understand that this amino acid regulates the synthesis of LH and testosterone in the pituitary and the testis respectively. This action is mediated in the pituitary by cGMP and in the testis by cAMP, which act as the second messengers in the signal transduction in the pituitary and testes respectively. The pituitary and testis possesses a D-Aspartate racemase, which provides the necessary production of D-Asp.
03-10-2011, 05:28 PM
I am pretty sure this shows that DAA has NMDA activity on its own..
Finally, D-Asp (100-1000 μM) stimulated PRL secretion and this effect was reduced by a NMDA receptor antagonist.
03-10-2011, 05:37 PM
03-10-2011, 06:12 PM
03-10-2011, 06:46 PM
i had great bb'ing effect from daa, strength and appetite both went way up-less than when i started test cyp but in the ballpark. difference was libido tanked.
03-10-2011, 07:27 PM
The benefits of early acceptence are to obtain the edge from a new product, the risk are the limited research on long-term use.
While your questions are valid, they're expensive to verify.
I would imagine test levels increase slowly, then rapidly, then begin to level off, and slowly start to wain with continued usage. This would require a lot of really expensive blood tests. Usually in doing a clinical study, the results are compromised by limited funds. There's an order of operations these tend to follow. You can see the same trend with creatine monohydrate in the 90's. First it's a matter of determining if the product does anything. When this is accomplished, then things progress to determine long-term use.
03-10-2011, 07:52 PM
03-10-2011, 08:04 PM
03-10-2011, 08:14 PM
Well I was planning on running DAA in my summer cut, very happy I found this thread the knowledge dropped has been awesome, now I will not be running DAA, sucks too because it works but I'm not wanting to mess with my brain, its already unstable enough
03-10-2011, 09:15 PM
My guess is that the natural formation from the L-isomer isn't all too significant. Too pick up the slack, you probably have a high receptor density, and thus the capacity for more more activation through external DAA supplementing.
03-10-2011, 09:17 PM
03-10-2011, 09:17 PM
03-10-2011, 10:36 PM
I started getting really bad anxiety on DAA and I've never had it before.. I've since stopped but am still getting it, but noticeably less often.. I don't suggest DAA is solely to blame for this, however it is interesting that it's declined since I stopped taking it.
03-11-2011, 12:51 AM
So to sum up what I've read thus far. DAA has been shown to increase test in in vivo studies, but nobody can produce a single study showing this excitotoxicity that some are stating as "fact." Please, if you have a study, post it, otherwise that is worse than bro science...it's bad science.
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