List of Glucose Disposal Agents
1. R-ALA R- (R-ALA), an active isomer of Lipoic Acid, is easily synthesized and metabolized by the body. R-ALA is 2 times more effective than regular (RS) Alpha Lipoic Acid and is a key component of mitochondrial dehydrogenase, which may help to slow the natural aging process in animals. Alpha lipoic acid is known as the "universal antioxidant" because of its unique solubility in both water and fat. It has the ability to conserve and prolong the life of vitamins C & E in the body, increasing their effectiveness. Alpha lipoic acid is also an excellent metal detoxifier, particularly for mercury and cadmium, which it binds to and neutralizes for excretion.
2. Bitter Melon contains four very promising bioactive compounds. These compounds activate a protein called AMPK, which is well known for regulating fuel metabolism and enabling glucose uptake, processes which are impaired in diabetics. "We can now understand at a molecular level why bitter melon works as a treatment for diabetes," said David James, director of the diabetes and obesity program at the Garvan Institute of Medical Research in Sydney. "By isolating the compounds we believe to be therapeutic, we can investigate how they work together in our cells." Bitter melon contains a lectin that has insulin-like activity. The insulin-like bioactivity of this lectin is due to its linking together 2 insulin receptors. This lectin lowers blood glucose concentrations by acting on peripheral tissues and, similar to insulin's effects in the brain, suppressing appetite. This lectin is likely a major contributor to the hypoglycemic effect that develops after eating bitter melon and why it may be a way of managing adult-onset diabetes. Lectin binding is non-protein specific, and this is likely why bitter melon has been credited with immunostimulatory activity - by linking receptors that modulate the immune system, thereby stimulating said receptors.
3. is native to India, and its leaves are a traditional folk medicine for diabetes. Several studies in humans and animals have confirmed it can improve glucose control, possibly by inhibiting glucose uptake in the small intestine and enhancing insulin release. It may even have positive effects on lipid metabolism and has potential for use in treating diabetes and obesity.
4. Phellodendron amurense is otherwise known as "Amur Cork Tree." A native of Asia, the bark has been used in Chinese traditional medicine to treat gastrointestinal problems, ulcers, diabetes and infections.Berberine is the best characterized of the compounds that have been identified. Berberine has antibacterial, anti-tumor and antioxidant activities. It may also have anti-diabetic activity: in one study, it decreased body fat and fasting glucose levels in rats. This work is not conclusive, however, as the berberine was administered by injection, not consumed orally. Unfortunately, we don't have many other in-vivo studies on berberine or Phellodendron.
5. or Chromium Polynicotinate or Chromium FTG or chelated Chromium a nutritional form of the essential mineral chromium, as a safe nutritional supplement that may reduce the risk of insulin resistance and possibly type 2 diabetes. One small study suggests that chromium picolinate may reduce the risk of insulin resistance, and therefore possibly may reduce the risk of type 2 diabetes. FDA concludes, however, that the existence of such a relationship between chromium picolinate and either insulin resistance or type 2 diabetes is highly uncertain. Chromium Polynicotinate is a niacin bound form of chromium picolinate which is considered less potentially toxic with better absorbsion qualities while FTG and the chelated form of chromium are from organic sources and considered the safest of all.
6. Vanadyl Sulfate Under normal conditions, the body contains 20 to 25 mg. of vanadium, and the average diet supplies about 2 mg. of vanadium per day. Food sources rich in vanadium include pepper, dill, radishes, eggs, vegetable oils, buckwheat and oats. Because of their organic environment, these natural sources are likely to be safer than over the counter preparations.
7. Cinnamon There has been a lot of talk these days about cinnamon. According to some studies, cinnamon may improve blood glucose and cholesterol levels in people with Type 2 diabetes. The results of a study from 2003 in Pakistan showed lower levels of fasting glucose, triglycerides, LDL cholesterol and total cholesterol after 40 days with levels continuing to drop for 20 days after that.
8. Vinegar You can lower blood sugar with apple cider vinegar, which has long been valued for its nutritive properties as a folk remedy. The health benefits and effect of apple cider vinegar on blood glucose levels has been clinically researched.
9. Corosolic acid, a triterpenoid found in the leaves, helps regulate blood sugar by stimulating glucose uptake. This blood sugar lowering effect is similar to that of insulin - which induces glucose transport from the blood into body cells. In a study of humans with type-2 diabetes, banaba extract showed a 30% reduction in blood glucose levels. It is considered a natural plant insulin, can be taken orally, and has no side effects, according to Japanese research. Corsolic acid also appears to have strong antioxidant properties.
10. Extracts of The chemical compounds found in fenugreek have the ability to aid the digestive process. Consequently, when taken with meals it is believed that fenugreek is able to slow down the rate at which sugars are absorbed into the body, whereby regulating blood sugar levels. Additionally, studies indicate that 4-hydroxyisoleucine (an amino acid) found in fenugreek may induce or promote the production of insulin when blood sugar levels are elevated.
11. is also known as "Veld Grape." It's another medicinal plant native to Africa, India, and other parts of Asia. Cissus has traditionally been used to treat a variety of ailments such as bone fractures, ulcers, wounds, indigestion and asthma. Animal studies have shown Cissus extracts may have gastroprotective effects, contribute to bone health, and have antioxidant/antimicrobial activities. A number of people swear by Cissus as an analgesic and use it to treat weight lifting injuries. Lately, Cissus has also been touted as a fat loss agent, thanks to two studies.The first was discussed by Paul in his review of Cylaris. Of course, this study actually tested the entire Cylaris formula—which makes it difficult to draw conclusions about Cissus itself. A second study, however, did test a proprietary Cissus extract (CQR-300) and concluded it "...brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors."
12. Phellodendron extract Anti-inflammatory, antipyretic, cholagogue, antibacterial, lowers blood sugar.
13. BMOV (Bis-Malto-Oxovanadium) BMOV is an organic form of the mineral vanadium. Although elemental vanadium and inorganic salts of vanadium show significant biological potential, it has a poor therapeutic index due to low gastrointestinal absorbance. BMOV is recognized as safer, more absorbable, and able to deliver a therapeutic effect up to 50% greater than the inorganic forms. (9) Vanadium is one of the rare microelements that can promote a profound boost in and strongly support anabolism. BMOV can give muscles a hardness like you have never experience before. The form of vanadium used in this formula is one of the very best you can find, if not the best.
14. Na-R-ALA(Na RALA is the sodium salt form of R-Lipoic Acid) Sodium R-Lipoate (Na-r-ALA)
ALA is naturally produced in the body as a mitochondrial enzyme cofactor. It is important to aerobic metabolism. ALA has been shown to increase cellular uptake of glucose to cell membranes by recruiting the glucose transporter GLUT4. ALA improves skeletal muscle glucose transport, resulting in desirable blood glucose disposal and increased muscle glycogen concentrations. (1) Studies also indicate that in muscle, ALA is a potent anti-oxidant which protects cells from oxidative stress-induced insulin resistance. (2) The ALA used in this formula is chemically stabilized and of the highest quality. It?s the most active isomer and the highest potency salt commercially available. ALA is an invaluable addition that offers a multitude of benefits plus countless extras for any serious athlete.
15. Magnolia officinalis Magnolia bark is used as a general anti-stress and anti-anxiety agent - so its claims typically center on general benefits in controlling stress and anxiety. Newer claims are emerging, however, to link magnolia's anti-stress benefits with control of the body's primary stress hormone, cortisol, and the myriad health benefits associated with normal cortisol levels (versus elevated cortisol, which has been associated with obesity, diabetes, osteoporosis, memory problems and suppressed immune function).
15. Lagerstroemia speciosa is Banaba—a tree native to Southeast Asia. The leaves have been used in traditional medicine in the Phillipines as a treatment for diabetes. As it turns out, the leaves are high in corosolic acid, which has been shown to improve glucose control in human and animal studies. It appears to do this by stimulating glucose uptake in muscle cells. Glucose transport is mediated by specific transporter proteins. Corosolic acid acts by increasing the amount of a particular transporter (GLUT-4) on the cell membrane surface. Although more work remains to be done, banaba looks like a useful ingredient for treating hyperglycemia and diabetes.