Dexaprine 3rd Party Test

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  1. Dexaprine 3rd Party Test


    If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone.

    I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use.


    A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.

    AuthorsVenhuis B, et al. Show all Journal
    Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print]

    Affiliation
    Abstract
    Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as β-methyl-β-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
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  2. I tried but came up empty
    "The only good is knowledge and the only evil is ignorance." - Socrates

  3. Dexaprine has three different versions correct? OG, V 2.0 (which still went by Dexaprine) and XR. I used V1, but didn't enjoy V2 nearly as much. Pretty sure I still have an unopened bottle of it. Never used XR.
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  4. Quote Originally Posted by Geoforce View Post
    Dexaprine has three different versions correct? OG, V 2.0 (which still went by Dexaprine) and XR. I used V1, but didn't enjoy V2 nearly as much. Pretty sure I still have an unopened bottle of it. Never used XR.
    I'm not sure. Hard to keep up. This is the label currently on their website for XR which matches what this analysis found.

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  5. Correction the Netherlands did ban it last year. And some chick in the UK overdosed on it after taking 20 ****ing pills.

    http://www.nutraingredients.com/Regu...es-DNP-warning
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  6. Quote Originally Posted by Royd The Noyd View Post
    If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone. I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. AuthorsVenhuis B, et al. Show all Journal Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print] Affiliation Abstract Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as ?-methyl-?-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.

    Just bought mine and have some left over as well.

    Pea's are pretty damn cool. Especially with an Mao b inhibitor and a couple added goodies. For the purpose of going out

  7. Interesting stuff here.
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  8. Quote Originally Posted by Royd The Noyd View Post
    If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone.

    I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use.


    A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.

    AuthorsVenhuis B, et al. Show all Journal
    Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print]

    Affiliation
    Abstract
    Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as β-methyl-β-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
    Everything they listed is a constituent of natural extracts which we use. This witch hunt is going strong.

  9. Quote Originally Posted by VaughnTrue View Post
    Everything they listed is a constituent of natural extracts which we use. This witch hunt is going strong.
    Yeah it meets label claims. Is it safe to assume XR is what they tested?
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  10. Quote Originally Posted by Royd The Noyd View Post
    Yeah it meets label claims. Is it safe to assume XR is what they tested?

    not a clue sorry man

  11. Quote Originally Posted by VaughnTrue View Post
    not a clue sorry man
    Speaks again to the validity of the "study" that they can't even list specifically what product they are testing.
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  12. Quote Originally Posted by PuZo View Post
    Speaks again to the validity of the "study" that they can't even list specifically what product they are testing.
    Do you have the full text? 98% of studies on specific supplements like this do not list the actual name of the supplement in the abstract. I'm surprised they even included "Dexaprine" in the abstract.
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  13. Quote Originally Posted by Royd The Noyd View Post
    Do you have the full text? 98% of studies on specific supplements like this do not list the actual name of the supplement in the abstract. I'm surprised they even included "Dexaprine" in the abstract.
    I do not. It's more alarmist propaganda. Everything they found was as listed on the label so it comes to question if whoever made this study has some sort of an agenda.

    This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances
    Everything they found was declared... so...
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  14. Quote Originally Posted by PuZo View Post
    I do not. It's more alarmist propaganda. Everything they found was as listed on the label so it comes to question if whoever made this study has some sort of an agenda.



    Everything they found was declared... so...
    Alarmist propaganda? Lol you cannot be serious. Do you know what a peer reviewed journal is?

    How do you know if everything they found was declared if you don't even know which version of Dexaprine they tested?
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  15. Quote Originally Posted by Geoforce View Post
    Dexaprine has three different versions correct? OG, V 2.0 (which still went by Dexaprine) and XR. I used V1, but didn't enjoy V2 nearly as much. Pretty sure I still have an unopened bottle of it. Never used XR.
    Correct. I still have some v1 and 3 bottles of v2 i bought on ebay 2 months ago at 20$ each lol...

  16. I have eaten many bottles of each version. Its golden...at least the US stuff.

  17. Quote Originally Posted by PuZo View Post
    Speaks again to the validity of the "study" that they can't even list specifically what product they are testing.
    FYI - reading an abstract does not equal reading a study.

    The point of the thread is to see if someone has access to the text so he can see if it is mentioned in thr study.


    Quote Originally Posted by PuZo View Post
    It's more alarmist propaganda.
    A few people had bad reactions to a product. In an industry that is notorious for spiking products they figured they would test the pills and see if there was anything extra in it. They list what they would which if it is XR then there wasnt anything extra.

    How is this alarmist propaganda?

    Showing that a product meets label claims and isnt spiked (assuming it was xr) is alarmist propaganda?
    "The only good is knowledge and the only evil is ignorance." - Socrates

  18. Quote Originally Posted by Royd The Noyd View Post
    Alarmist propaganda? Lol you cannot be serious. Do you know what a peer reviewed journal is?

    How do you know if everything they found was declared if you don't even know which version of Dexaprine they tested?
    Quote Originally Posted by JudoJosh View Post
    A few people had bad reactions to a product. In an industry that is notorious for spiking products they figured they would test the pills and see if there was anything extra in it. They list what they would which if it is XR then there wasnt anything extra.

    How is this alarmist propaganda?

    Showing that a product meets label claims and isnt spiked (assuming it was xr) is alarmist propaganda?
    I was speaking in part due to the comment at the end:

    This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances
    What undeclared active substances did they find? The propaganda is you're scaring the general public by spreading misinformation. There are 2 point of views from this abstract. You have the one that says everything found in their test was listed on the ingredient panel, and then you have the other stating undeclared active substances... so which is it?
    iForce Nutrition Representative
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  19. Quote Originally Posted by PuZo View Post
    I was speaking in part due to the comment at the end:



    What undeclared active substances did they find? The propaganda is you're scaring the general public by spreading misinformation. There are 2 point of views from this abstract. You have the one that says everything found in their test was listed on the ingredient panel, and then you have the other stating undeclared active substances... so which is it?
    They tested the product and indicated something in it was undeclared. There is nothing in the abstract that states everything they found was listed in the ingredient panel. They are spreading factual information based on their findings. Just bc the abstract doesn't list the undeclared ingredient doesn't mean there wasn't one in there.
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  20. All I know about dexaprine XR is that that **** had me shaking worse than clenbuterol. Made me hot and jittery with chills. Thoroughly unpleasant.

  21. I still have a bunch of the original. I'll pass it out at work and see what everybody has to say, haha.
    I liked it when I tried it.
    RcB Since 09-06-2011 20:55 EST, Post 49

  22. Quote Originally Posted by BamBam0319 View Post
    All I know about dexaprine XR is that that **** had me shaking worse than clenbuterol. Made me hot and jittery with chills. Thoroughly unpleasant.
    if you didn't like this, you surely wouldn't like liquid clebutrx hardcore by VPX lulz
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  23. Quote Originally Posted by EBF Inc View Post

    Just bought mine and have some left over as well.

    Pea's are pretty damn cool. Especially with an Mao b inhibitor and a couple added goodies. For the purpose of going out
    What exactly would you recommend?

  24. Could they be talking about the β-methyl-β-phenylethylamines when they say "undeclared".
    NSCA-CSCS and CPT - Pursuing DPT Degree

  25. Quote Originally Posted by haiz69 View Post
    Could they be talking about the β-methyl-β-phenylethylamines when they say "undeclared".
    Well, considering that is most likely in reference to acacia rigidula, then probably not:

    http://en.wikipedia.org/wiki/N-Methylphenethylamine
    iForce Nutrition Representative
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  26. I've searched far and wide, and I cannot access this text. It is quite protected lol
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES

  27. Don't they have a website?

  28. Quote Originally Posted by BamBam0319 View Post
    All I know about dexaprine XR is that that **** had me shaking worse than clenbuterol. Made me hot and jittery with chills. Thoroughly unpleasant.
    Same here! I had to bin the bottle - the worst stim I have ever taken. I'm not bashing iFroce, because I do use some of their other products, but this one felt dangerous.

  29. Email the author
    "The only good is knowledge and the only evil is ignorance." - Socrates

  30. Quote Originally Posted by PuZo View Post
    Well, considering that is most likely in reference to acacia rigidula, then probably not:

    http://en.wikipedia.org/wiki/N-Methylphenethylamine
    I only say that because since the label only list Acacia and not what it is standardized for, that when they found the phenethylamines, that they would consider them "unlabeled".
    NSCA-CSCS and CPT - Pursuing DPT Degree

  31. Quote Originally Posted by haiz69 View Post
    I only say that because since the label only list Acacia and not what it is standardized for, that when they found the phenethylamines, that they would consider them "unlabeled".
    I think this is exactly what we will come to find out. Maybe...
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  32. Quote Originally Posted by JudoJosh View Post
    Email the author
    Gave it a shot...pending reply.
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  33. Quote Originally Posted by Royd The Noyd View Post
    Gave it a shot...pending reply.
    I put a request in as well
    "The only good is knowledge and the only evil is ignorance." - Socrates

  34. Quote Originally Posted by Royd The Noyd View Post
    I think this is exactly what we will come to find out. Maybe...
    That would be my guess, especially considering all the hoopla over different forms of B-PEA's being structurally similar to amphetamine. Of course, we know that they don't act that way secondary to varied metabolism, but most won't dig that deep.
    NSCA-CSCS and CPT - Pursuing DPT Degree

  35. Quote Originally Posted by haiz69 View Post
    I only say that because since the label only list Acacia and not what it is standardized for, that when they found the phenethylamines, that they would consider them "unlabeled".
    And that's the issue we face. Are these authors familiar with DSHEA, in it's entirety, and what is allowed to be labelled.
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  36. Quote Originally Posted by PuZo View Post
    And that's the issue we face. Are these authors familiar with DSHEA, in it's entirety, and what is allowed to be labelled.
    DSHEA is a USA law. Not the same as the European Commission regulations.
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  37. Quote Originally Posted by Royd The Noyd View Post
    DSHEA is a USA law. Not the same as the European Commission regulations.
    Very well then. Are the authors familiar with the European Commission regulations?
    iForce Nutrition Representative
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  38. I briefly looked over the full study (4 pages).. their main gripe is that they want active's to be listed on the label.
    They also claim unnaturally high levels of theophylline.. which doesn't really make sense...

    That's like saying a 5g serving of creatine mono contains "unnaturally" high levels of creatine that you can't find in nature.
    iForce Nutrition Representative
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  39. Quote Originally Posted by PuZo View Post
    I briefly looked over the full study (4 pages).. their main gripe is that they want active's to be listed on the label.
    They also claim unnaturally high levels of theophylline.. which doesn't really make sense...

    That's like saying a 5g serving of creatine mono contains "unnaturally" high levels of creatine that you can't find in nature.
    They may be saying that the theophylline content exceeds that which is naturally extractable from the plant.
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES

  40. coop... that's why they use 2 whole plants per bottle man.
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