If anyone can access this full text I would appreciate it. It seems to technically meet label claims, although I'm not certain what PEA forms they found based on the abstract alone.
I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use.
A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.
AuthorsVenhuis B, et al. Show all Journal
Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print]
Affiliation
Abstract
Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as β-methyl-β-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
I'm also not sure if it was "Dexaprine" or "Dexaprine XR" that was sold in Europe. There were however several adverse events reported there in the last half of 2013 and several European countries were warning consumers to avoid its use.
A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events.
AuthorsVenhuis B, et al. Show all Journal
Drug Test Anal. 2014 May 6. doi: 10.1002/dta.1664. [Epub ahead of print]
Affiliation
Abstract
Food supplements are regularly found to contain pharmacologically active substances. Recently, the food supplement Dexaprine was removed from the Dutch market because it was associated with severe adverse events. Reports to the Dutch Poisons Information Center (DPIC) showed that ingestion of as little as half a tablet caused several cases of nausea, agitation, tachycardia, and palpitations and even one case of cardiac arrest. The remaining tablets of four patients were sent in by different healthcare professionals. Analysis by ultra-performance liquid chromatography quadrupole time of flight mass-spectrometry (UPLC-QTOF-MS) confirmed the presence of synephrine, oxilofrine, deterenol, yohimbine, caffeine, and theophylline. Two more compounds were found which were tentatively identified as β-methyl-β-phenylethylamines. This incident is only the next in a series of similar incidents involving dietary supplements with (undeclared) active substances that are either unsafe or have no known safety profile. Copyright © 2014 John Wiley & Sons, Ltd.