forskolin use during androgen PCT may help with recovery

  1. forskolin use during androgen PCT may help with recovery

    Adenosine 3',5'-monophosphate and testosterone responses of normal and desensitized Leydig cells to forskolin.


    Forskolin has a potent stimulatory effect on both cyclic AMP and testosterone formation by purified Leydig cells. Forskolin also markedly enhanced hCG-induced cyclic AMP formation, but maximal testosterone production remained unaltered. Cyclic AMP and testosterone responses of desensitized Leydig cells to in vitro hCG stimulation were completely lost. Cholera toxin-induced cyclic AMP formation was also reduced. However, forskolin was able to stimulate a 3.4-fold increment in cyclic AMP formation and potentiate hCG-induced cyclic AMP response by desensitized Leydig cells. The absolute cyclic AMP levels were significantly lower than in normal control cells. These results suggest that the catalytic unit remains intact in desensitized Leydig cells and the coupling between N-protein and catalytic unit is impaired. The N-protein is required for full expression of maximal response of Leydig cells to forskolin.

    "The only good is knowledge and the only evil is ignorance." - Socrates

  2. Yep, and this has manifested in vivo with increases in T and free T.

  3. Nice article I will have to keep this in mind.

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