USPlabs Patented Anabolic - Beta-Test Review/Feedback

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  1. Quote Originally Posted by bolt10 View Post
    Nice updates.
    Thank you!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.


  2. Days 19 - 21 [December 4 - December 6]

    Preface

    Dosage here was, as in the earlier cases, one (1) capsule daily with meals (pre-workout meals on workout days and breakfast on non-workout days). Although I am neither aware of the name of the specific compound(s) in Patented Anabolic, nor am I aware of the specific mechanism(s) of action (MOA) through which it(they) exert(s) its(their) pharmacological effects, in what follows, I will attempt to speculate on some of the possible mechanisms I suspect are behind the results I have accumulated so far.
    At this point in time, I am roughly ten days to the end of the log. During the past three weeks, I have experienced results that are for me impressive. In particular, at above-maintenance feeding, I have noticed efficient nutrient utilization, denser muscles, and markedly enhanced exercise-related and non-exercise-related physical performance.

    Observations/Results:

    Having consistently stayed on excess (about 10% above-maintenance) caloric consumption, lipolysis should have been obstructed and subcutaneous adipose accumulation should ordinarily have ensued. The reality has been different, however. In particular, I have experienced an accumulation of lean mass, reflecting, to my mind, a combination of anabolic action, cyclic-AMP mediation, and some beta-adrenoceptor-type stimulation, resulting in improved protein-synthetic mechanisms and diminution in subcutaneous adipose stores.

    1) Muscle-fullness and vascularity

    I can report increased Muscle-fullness, muscle-hardness/density, and vascularity, both in resting and non-resting states, one of my favorite results from Patented Anabolic so far. As is obvious, muscle-fullness and enhanced vascular tone are associated with improved lean mass and reduction of subcutaneous adipose expression. In part, these effects are probably downstream results of beta-adrenergic and cAMP-mediated processes, ignoring for a moment the potentially purely anabolic aspects of Patented Anabolic. More on this shortly. Before then, let us focus for a second or two on vasodilation itself.

    Broadly stated, vasodilation precedes vascularity. Put differently, improved vascularity is hard to imagine without enhanced vasodilation. As it turns out, there exists consensus that vasodilation (also coronary/pulmonary artery vasodilation) can be induced by androgens, especially testosterone. Furthermore, these androgens can produce enhanced muscle density and hardness, and ultimately aesthetic vascularity. In particular, like I have stated elsewhere, endothelium-dependent (partly via nitric-oxide enhancement) and non-endothelium-dependent/endothelium-independent (via smooth-muscle ion conductance) pathways are mechanisms through which androgens, for example, testosterone can induce an impact on vascular tone. In my observation, the pre-dominance of muscle density, muscle-fullness, and vascularity appears to be a reflection of a deeper metabolic-endocrine effect, namely the increased endogenous production of androgens, particularly, testosterone.

    Furthermore, vasodilation is, again, like I have stated elsewhere, in part more a function of improved stimulation of beta-2 adrenoceptors on the endothelial surface of skeletal-muscle blood vessels than the stimulation of the alpha-1 (and alpha-2) adrenoceptors (in the proximity of the sympathetic nerve terminals) that would lead to vasoconstriction. Vasodilation and increased blood flow play an important role in lipolysis, as the by-products of lipolysis, such as non-esterified fatty acids and glycerol, are better transported to oxidative sites (although glycerols, unlike non-esterified fatty acids, are water-soluble and can consequently diffuse out of adipose cells into extracellular circulation).

    2) Strength/Endurance

    Strength and endurance, especially intra-exercise, as well as workout load, duration, and intensity have seen significant improvements since the start of my Patented Anabolic run. Chances are, that this might be related to the efficient utilization of free fatty acids for fuel, as metabolites of the lipolytic process initiated by Patented Anabolic. These improvements in workout load, duration, and intensity are clearly attributable to Patented Anabolic. Apart from the pronounced boost in ATP-synthetic effects that translate into superior cardiovascular capacity, enhanced strength and endurance are also known to be a reflection of testosterone's anabolic activity expressed via direct stimulation of increased muscle-synthetic response.

    Furthermore, improvements in strength and endurance represent, for me, central outcomes of Patented Anabolic supplementation, as energy recruitment improves with structural enhancements in skeletal muscle integrity and efficiency. So, altogether, Patented Anabolic appears to acts as an ergogenic agent that not only promotes increases in muscle and energy-producing tissues, but also positively influences the availability of energy and its rate of regeneration, resulting in improved strength and endurance.

    3) Body Recomposition

    By now, I can report amplified changes in body composition. In particular, I refer to greater leaning effects, improved visual manifestation of enhanced lean mass, as well as elevated lipolytic and anti-catabolic effects. More compactly, I report more noticeable shifts toward receding adipose accumulation and elevated muscular expression. Altogether, endogenous androgen-induced hormonal manipulation positively impacts the metamorphosis of stem cells into satellite cells at the expense of pre-adipocytes, and ultimately leads to enhanced hypertrophy and reduced fat mass. Body-compositional changes, like muscle-density and muscular tone, are also, I postulate, modulated by beta-adrenergic and cAMP-mediated metabolic mechanisms.

    Consider the significance of this for a second! Insignificant fat accumulation on above-maintenance feeding!

    The results here remind me of an earlier product log. In particular, cumulative changes in body composition have been positive: a pronounced improvement in lean-mass-to-fat-mass ratio, with noticeable aesthetic enhancements in muscular tone. All this on an above-maintenance caloric feeding! As is well known, beyond being a storage unit for energy (as triacylglycerol) and acting as an insulator, adipose tissue is metabolically active. Usually, feeding should inhibit lipolysis via its stimulation of insulin release and the consequent impact on the enzyme, hormone sensitive lipase (HSL), the rate-limiting enzyme for lipolysis. On the other hand, fasting and exercise have the opposite (favorable) effect on lipolysis by reducing insulin and recruiting catecholamines such as noradrenaline (norepinephrine) and adrenaline (epinephrine), the main hormones involved in the regulation of lipid status. These catecholamines act as first messengers in the lipolytic cascade that lead to beta-adrenoceptor activation and downstream activation of the second messenger (cAMP) that ultimately induces thermogenesis and lipolysis in visceral, subcutaneous, and gluteofemoral (buttocks and thighs) sites with varying results reflecting adrenoceptor distribution. So, the results I have seen so far appear to me to be consistent with the postulated adrenergic pathway to lipolysis and thermogenesis. Finally, recall, too, that testosterone also upregulates beta-adrenoceptors in the abdominal and other regions, explaining one pathway it employs to induce lipolysis.

    4) Other Effects [Hair loss, acne, lethargy, spontaneous mood swings, and related]

    No negative side effects have been observed.

    General comments and Next Steps:

    As I mentioned earlier, free fatty acids as a preferred source of fuel can power exercise sessions, leading to improvements in strength and endurance, aside from initiating favorable body-compositional changes. As is well known, lipolysis is the breakdown of triglycerides in adipocytes to form fatty acids and glycerol. These fatty acids and glycerol are eliminated from fat cells by passive diffusion, transported across the cell membrane via protein transporters and are ultimately shuttled into the bloodstream to be expensed as fuel by other cells and tissues.

    I speculate that the effects I have seen so far in the course of taking Patented Anabolic are due to a combination of direct anabolic effects (possibly due to hormonal modulation), beta-adrenergic effects, as well as cyclic-AMP-mediated effects.

    Recall that 3,5 cyclic adenosine monophosphate (cAMP) is the messenger for beta adrenoceptors. Increased cAMP levels are known to, for instance, stimulate lipolytic activity, trigger the levels of a Leydig-cell cholesterol-transfer protein, known as steroidogenic acute regulatory protein (StaR) and steroidogenesis, stimulate the HPTA, inhibit platelet aggregation, improve thyroid function, improve the contractile force of cardiac muscles, boost fat metabolism, and so on. Put differently, cyclic AMP and the host of chemical actions and metabolic processes it activates, together form a complex second messenger system that modulates the intricate and powerful effects of hormones in our body, both lipolytic/anti-catabolic and anabolic.

    Now, as is well-known, adrenergic receptors, or adrenoceptors, belong to the G-protein class of coupled receptors, and are the most prominent receptors in the adipose membrane, besides also being expressed in skeletal muscle tissue. These adipose-membrane receptors are classified as either alpha- or beta-adrenoceptors. Although these beta and alpha adrenoceptors share the same messenger, cyclic adenosine monophosphate (cAMP), the specific transduction pathway depends on the receptor type (alpha or beta). The beta adrenoceptors, in particular the beta-2 adrenoceptors, are the most thermogenic and lipolytic, and also induce anabolic effects. In particular, the stimulation of beta-2 adrenoceptors triggers vasodilation in muscle tissue, and promotes oxygen uptake and nutrient transportation to muscle tissue. Furthermore, beta-2 adrenergic receptors are direct thermogenic activators via stimulating direct increases in fatty acid oxidation. Increased oxidation of fatty acids in skeletal muscle cells promotes leaning. To continue, activation of beta-2 adrenoceptors directly upregulates uncoupling proteins 2 and 3 in skeletal muscle cells, leading to enhanced energy expenditure and impairment of the anti-lipolytic effects of alpha-2 adrenoceptors. Overall, the lipolytic and thermogenic beta-adrenoceptors promote the uptake of fatty acids into perixosomes and mitochondria, leading to the oxidation of fats, not carbohydrates, for energy. Furthermore, beta adrenergic stimulation, in particular, tends to exhibit a potential for anabolic activity. The specific anabolic activity of beta-adrenoceptors depends in some cases on the duration of their interaction with receptors in skeletal muscle cells, or whether or not they bypass the liver (thus circumventing first-pass degradation). Examples of anabolic effects from beta-adrenergic stimulation include improved muscle strength, preservation of lean mass (anti-catabolic action), improved nitrogen retention and improved protein synthesis in skeletal muscles (even during caloric restriction).

    Patented Anabolic has been incredible so far. It is like I am stacking PowerFULL, Pink Magic, PRIME, and Anabolic Pump! I have experienced and reported solid improvements in different classes as enumerated earlier. After three weeks of Patented Anabolic, I have experienced remarkable cumulative anabolic effects, without any androgenic sides.

    The next review will cover Days 22-24. Thank you for following this review!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
    •   
       


  3. Days 22 - 24 [December 7 - December 9]

    Preface

    Dosage in this review period was the regular one (1) capsule daily with meals (pre-workout meals on workout days and breakfast on non-workout days).

    Observations/Results:

    A solid run so far. Recall this is a solo Patented Anabolic log, so I can legitimately ascribe all of the effects I have described so far (and may describe in the remaining part of the log) to the compound.

    1) Muscle-fullness and Vascularity

    Here, I report amplified resting and non-resting muscular definition (density, hardness, fullness) and vascular tone. Put differently, muscle-density and hardness, muscle-fullness, and generalized enhancements in vascularity are dominant, and are probably positively influenced by some mechanism involving amplified downstream endogenous production of testosterone.

    2) Strength/Endurance

    Clearly, Patented Anabolic exhibits significant ergogenic effects. Possibly following from its modulation of ATP-resynthetic mechanisms, energy availability and regeneration have not only been magnified, but have consistently manifested themselves in undeniable enhancements in strength and endurance. Increased workout load, duration, and intensity are the concrete results from my Patented Anabolic supplementation in this area. This is the basis for my classification of Patented Anabolic as an ergogenic agent, as it appears to not only promote increases in muscle and energy-producing tissues, but also positively influences the availability of energy and its rate of regeneration, resulting in improved strength and endurance.

    3) Body Recomposition

    Patented Anabolic appears to promote enhanced muscle definition and vascular tone as the foundation for favorable body recomposition. This effect is directly related to my earlier comment that Patented Anabolic appeared to exert a positive effect on protein synthesis and nitrogen retention, coupled with the thermogenic-lipolytic processes I mentioned in the last review, to produce a structural shift away from adipogenesis and to hypertrophy and anabolism.

    3) Negative Side Effects [Hair loss, acne, lethargy, spontaneous mood swings, and related]

    No negative side effects have been observed.


    General Comments and Next Steps:

    Rest, sleep, muscle-tissue repair and recovery are significant. Apart from the direct anabolic effect of muscle-tissue repair, Patented Anabolic may also exert a positive effect on lactic-acid modulation, as well as delivering adaptogenic and anti-oxidant properties that express themselves in stress adaptation and beneficial regulation of metabolic processes that inhibit catabolism and prime the body for optimal growth, collectively contributing to not just muscle preservation, but also to muscle growth. Furthermore, associated with Patented Anabolic supplementation is increased positive aggression, assertiveness, and libido, all effects that are associated with an increased endogenous production of testosterone.

    The next review will cover Days 25-27. Thank you for following this review!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  4. Days 25 - 27 [December 10 - December 12]

    Preface

    Dosage in this review period was the regular one (1) capsule daily with meals (pre-workout meals on workout days and breakfast on non-workout days).


    Observations/Results:


    This is my penultimate review. It has been close to four weeks of a solo run of Patented Anabolic, and my experience has been remarkable. Increased hunger. Upped macronutrient consumption. Efficient nutrient partitioning. Enhanced lean mass. Heightened exercise intensity. Improved strength and endurance. Positive aggression. Phenomenal indeed.


    1) Muscle-fullness and Vascularity


    As I have consistently reported in the last couple of reviews, one of my favorite aspects of this compound is amplified resting and non-resting muscle fullness and density, combined with pronounced vascularity. Consistent with an earlier suggestion I made, these results might be related to an improved efficiency in macronutrient partitioning and utilization. In turn, these are partly (anabolic) protein-synthetic effects (net positive nitrogen retention) that can be induced by testosterone, growth hormones, or a combination of the two [and possibly anti-glucocorticoid effects associated with lean-mass retention] and their aggregate impact on vasodilation and vascularity via endothelium-dependent (partly via nitric-oxide enhancement) and non-endothelium-dependent/endothelium-independent (via smooth-muscle ion conductance) pathways.


    2) Strength/Endurance


    In line with an earlier exposition, Patented Anabolic appears to exhibit powerful ergogenic results that may be downstream effects of regulating phosphocreatine- ATP-resynthetic proceses. Put differently, it appears to not just promote increases in muscle and energy-producing tissues, but also apperas to positively influence the availability of energy and its rate of regeneration, leading to improved strength and endurance.


    3) Body Recomposition


    Earlier, I reported enhanced muscle-fullness and vascularity. These are clearly outward manifestations of deep metabolic processes that also induce body-recompositional effects. Effectively, body recomposition is a function of hormonal processes. In particular, following from a change in hormonal status, a certain combination of lipolytic/thermogenic processes, anabolic and anti-catabolic mechanisms, as well as a preferential shift in the development of stem cells toward the growth of muscle satellite cells at the expense of pre-adipocytes occurs, leading to increased lean mass and reduced fat mass.


    3) Negative Side Effects [Hair loss, acne, lethargy, spontaneous mood swings, and related]


    No negative side effects have been observed.


    General Comments and Next Steps:


    My previous comments here remain valid: Rest, sleep, muscle-tissue repair and recovery are significant. Apart from the direct anabolic effect of muscle-tissue repair, Patented Anabolic may also exert a positive effect on lactic-acid modulation, as well as delivering adaptogenic and anti-oxidant properties that express themselves in stress adaptation and beneficial regulation of metabolic processes that inhibit catabolism and prime the body for optimal growth, collectively contributing to not just muscle preservation, but also to muscle growth. Furthermore, associated with Patented Anabolic supplementation are increased positive aggression, assertiveness, and libido, all effects that are associated with an optimized regulation of hormonal status.

    The next review will be the final, and will cover the results of the full 30 days of supplementation. Thank you for following this review!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  5. Final Patented Anabolic Review:

    Beginning of supplementation: November 16, 2012
    Last day of supplementation: December 15, 2012
    Length of Run: 30 days
    Dosage: One (1) capsule daily with meals (pre-workout meals on workout days and breakfast on non- workout days).
    Stack: Solo run (Patented Anabolic only, at recommended dosage)
    Starting statistics: 110kg (242.5 lbs) and 12% BF
    Ending statistics: 113.0kg (249.1 lbs) and 11.1% BF
    Caloric intake: Above maintenance (about +10% on average)

    As they say, whatever has a beginning, must have an end. And so I come to the final review of my Patented Anabolic solo run, spanning 30 truly transformational days. Dosage was consistent at one capsule daily with meals (pre-workout meals on workout days and breakfast on non-workout days). It was, indeed, an incredible journey. Rich. Intense. Focused!

    In what follows, I will summarize my experiences with, and results from, the product, consistent with my earlier comments and reports, in addition to the summary in the preceding section of this final review. Obviously, as this was a solo run, all the results documented here, in no particular order, are solely attributable to Patented Anabolic alone.



    1. Potent stimulation of hunger signals, inevitably leading to above-maintenance caloric exposure, an apparently essential component and pre-condition for the products’ anabolic effects (see (2) below).
    2. Distinct and powerful up-regulation of macronutrient-uptake, partitioning, and utilization efficiency, coupled with an intense stimulation of anabolic (protein-synthetic and nitrogen-retention) and muscle-sparing (anti-catabolic) processes.
    3. Noticeably enhanced intra-workout muscle contractions and resting muscle density and fullness, coupled with a cumulative boost in (intra- and post-exercise) vasodilation, striation, and vascular expression.
    4. Unmistakably pronounced ergogenic effects, possibly via stimulation of ATP regeneration/re-synthesis and enhanced energy regulation, ultimately leading to amplified improvements in strength and endurance and manifested in increased workout load and intensity, as well as reduced fatigue and shortened post-exercise recovery length.
    5. Distinct, preferential and disproportionate shift in body composition in favor of greater expression of dense and lean muscle tissue at the expense of accumulation of adipose mass, consistent with the enhancement in anabolic/anti-catabolic/lipolytic signals and processes that cumulatively led to net-new muscle tissue.
    6. Increased assertiveness and positive aggression without (androgenic) side effects.



    Altogether, Patented Anabolic, in my view, packs true potential. Without knowing the constituent ingredient(s) of the product, my log experience suggests to me that Patented Anabolic has the potential to induce a multitude of desirable effects (anabolic, anti-catabolic, lipolytic, ergogenic) in a potent and amplified manner, making it a legitimate candidate, not only for a solo run, but also for inclusion in a variety of stacks in different directions (lean bulk, bulk, strength, fat-loss). As the effects, at least in my case, were cumulative, an optimal duration for Patented Anabolic’s use should be about eight (8) weeks, to allow for a full course of the product’s potent results. Appropriately, I am truly looking forward to being able to use this product for this postulated length of time.

    Overall, I will not hesitate to recommend Patented Anabolic unconditionally.

    Finally, I would like to thank Jacob for giving me the opportunity to beta-test this product. Thank you!

    To everyone else I say thank you very much for following my log, actively or passively!


    Vielen Dank und bis bald!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
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  6. On Board!!!! my friend!

  7. Quote Originally Posted by MAxximal View Post
    On Board!!!! my friend!
    Thank you!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  8. Nice work, buddy.
    Serious Nutrition Solutions Representative

  9. Quote Originally Posted by Distilled Water View Post
    Nice work, buddy.
    Thank you, DW!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  10. Reading Ike's posts makes me feel very unintelligent.

    In turn, these are partly (anabolic) protein-synthetic effects (net positive nitrogen retention) that can be induced by testosterone, growth hormones, or a combination of the two [and possibly anti-glucocorticoid effects associated with lean-mass retention] and their aggregate impact on vasodilation and vascularity via endothelium-dependent (partly via nitric-oxide enhancement) and non-endothelium-dependent/endothelium-independent (via smooth-muscle ion conductance) pathways.
    ... my log is like "here is a shot of my abs, bro".

    Great work, Ike.
    PEScience Representative
    http://pescience.com/insider
    http://selectprotein.com

  11. Nice review of the 30 days of use.

  12. Quote Originally Posted by bolt10 View Post
    Nice review of the 30 days of use.
    Thank you!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  13. Quote Originally Posted by bdcc View Post
    Reading Ike's posts makes me feel very unintelligent.
    Incredible modesty, my friend! You know you are very sharp!

    ... my log is like "here is a shot of my abs, bro".
    A "shot" speaks a thousand words!


    Great work, Ike.
    Thank you for your support!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  14. That's strat for that very informational run on patented anabolic. Now knowing what it can really do I can add it to my stacks accordingly.

  15. Quote Originally Posted by 808shredded View Post
    That's strat for that very informational run on patented anabolic. Now knowing what it can really do I can add it to my stacks accordingly.
    Awesome. Glad you found my review useful. Thank you!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  16. Patented Anabolic is USPlabs VERSA-1™ and is coming soon:

    http://usplabsdirect.com/forum/topic...st-click-here/
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
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