Days 19 - 21 [December 4 - December 6]
Preface
Dosage here was, as in the earlier cases, one (1) capsule daily with meals (pre-workout meals on workout days and breakfast on non-workout days). Although I am neither aware of the name of the specific compound(s) in Patented Anabolic, nor am I aware of the specific mechanism(s) of action (MOA) through which it(they) exert(s) its(their) pharmacological effects, in what follows, I will attempt to speculate on some of the possible mechanisms I suspect are behind the results I have accumulated so far.
At this point in time, I am roughly ten days to the end of the log. During the past three weeks, I have experienced results that are for me impressive. In particular, at above-maintenance feeding, I have noticed efficient nutrient utilization, denser muscles, and markedly enhanced exercise-related and non-exercise-related physical performance.
Observations/Results:
Having consistently stayed on excess (about 10% above-maintenance) caloric consumption, lipolysis should have been obstructed and subcutaneous adipose accumulation should ordinarily have ensued. The reality has been different, however. In particular, I have experienced an accumulation of lean mass, reflecting, to my mind, a combination of anabolic action, cyclic-AMP mediation, and some beta-adrenoceptor-type stimulation, resulting in improved protein-synthetic mechanisms and diminution in subcutaneous adipose stores.
1) Muscle-fullness and vascularity
I can report increased Muscle-fullness, muscle-hardness/density, and vascularity, both in resting and non-resting states, one of my favorite results from Patented Anabolic so far. As is obvious, muscle-fullness and enhanced vascular tone are associated with improved lean mass and reduction of subcutaneous adipose expression. In part, these effects are probably downstream results of beta-adrenergic and cAMP-mediated processes, ignoring for a moment the potentially purely anabolic aspects of Patented Anabolic. More on this shortly. Before then, let us focus for a second or two on vasodilation itself.
Broadly stated, vasodilation precedes vascularity. Put differently, improved vascularity is hard to imagine without enhanced vasodilation. As it turns out, there exists consensus that vasodilation (also coronary/pulmonary artery vasodilation) can be induced by androgens, especially testosterone. Furthermore, these androgens can produce enhanced muscle density and hardness, and ultimately aesthetic vascularity. In particular, like I have stated elsewhere, endothelium-dependent (partly via nitric-oxide enhancement) and non-endothelium-dependent/endothelium-independent (via smooth-muscle ion conductance) pathways are mechanisms through which androgens, for example, testosterone can induce an impact on vascular tone. In my observation, the pre-dominance of muscle density, muscle-fullness, and vascularity appears to be a reflection of a deeper metabolic-endocrine effect, namely the increased endogenous production of androgens, particularly, testosterone.
Furthermore, vasodilation is, again, like I have stated elsewhere, in part more a function of improved stimulation of beta-2 adrenoceptors on the endothelial surface of skeletal-muscle blood vessels than the stimulation of the alpha-1 (and alpha-2) adrenoceptors (in the proximity of the sympathetic nerve terminals) that would lead to vasoconstriction. Vasodilation and increased blood flow play an important role in lipolysis, as the by-products of lipolysis, such as non-esterified fatty acids and glycerol, are better transported to oxidative sites (although glycerols, unlike non-esterified fatty acids, are water-soluble and can consequently diffuse out of adipose cells into extracellular circulation).
2) Strength/Endurance
Strength and endurance, especially intra-exercise, as well as workout load, duration, and intensity have seen significant improvements since the start of my Patented Anabolic run. Chances are, that this might be related to the efficient utilization of free fatty acids for fuel, as metabolites of the lipolytic process initiated by Patented Anabolic. These improvements in workout load, duration, and intensity are clearly attributable to Patented Anabolic. Apart from the pronounced boost in ATP-synthetic effects that translate into superior cardiovascular capacity, enhanced strength and endurance are also known to be a reflection of testosterone's anabolic activity expressed via direct stimulation of increased muscle-synthetic response.
Furthermore, improvements in strength and endurance represent, for me, central outcomes of Patented Anabolic supplementation, as energy recruitment improves with structural enhancements in skeletal muscle integrity and efficiency. So, altogether, Patented Anabolic appears to acts as an ergogenic agent that not only promotes increases in muscle and energy-producing tissues, but also positively influences the availability of energy and its rate of regeneration, resulting in improved strength and endurance.
3) Body Recomposition
By now, I can report amplified changes in body composition. In particular, I refer to greater leaning effects, improved visual manifestation of enhanced lean mass, as well as elevated lipolytic and anti-catabolic effects. More compactly, I report more noticeable shifts toward receding adipose accumulation and elevated muscular expression. Altogether, endogenous androgen-induced hormonal manipulation positively impacts the metamorphosis of stem cells into satellite cells at the expense of pre-adipocytes, and ultimately leads to enhanced hypertrophy and reduced fat mass. Body-compositional changes, like muscle-density and muscular tone, are also, I postulate, modulated by beta-adrenergic and cAMP-mediated metabolic mechanisms.
Consider the significance of this for a second! Insignificant fat accumulation on above-maintenance feeding!
The results here remind me of an earlier product log. In particular, cumulative changes in body composition have been positive: a pronounced improvement in lean-mass-to-fat-mass ratio, with noticeable aesthetic enhancements in muscular tone. All this on an above-maintenance caloric feeding! As is well known, beyond being a storage unit for energy (as triacylglycerol) and acting as an insulator, adipose tissue is metabolically active. Usually, feeding should inhibit lipolysis via its stimulation of insulin release and the consequent impact on the enzyme, hormone sensitive lipase (HSL), the rate-limiting enzyme for lipolysis. On the other hand, fasting and exercise have the opposite (favorable) effect on lipolysis by reducing insulin and recruiting catecholamines such as noradrenaline (norepinephrine) and adrenaline (epinephrine), the main hormones involved in the regulation of lipid status. These catecholamines act as first messengers in the lipolytic cascade that lead to beta-adrenoceptor activation and downstream activation of the second messenger (cAMP) that ultimately induces thermogenesis and lipolysis in visceral, subcutaneous, and gluteofemoral (buttocks and thighs) sites with varying results reflecting adrenoceptor distribution. So, the results I have seen so far appear to me to be consistent with the postulated adrenergic pathway to lipolysis and thermogenesis. Finally, recall, too, that testosterone also upregulates beta-adrenoceptors in the abdominal and other regions, explaining one pathway it employs to induce lipolysis.
4) Other Effects [Hair loss, acne, lethargy, spontaneous mood swings, and related]
No negative side effects have been observed.
General comments and Next Steps:
As I mentioned earlier, free fatty acids as a preferred source of fuel can power exercise sessions, leading to improvements in strength and endurance, aside from initiating favorable body-compositional changes. As is well known, lipolysis is the breakdown of triglycerides in adipocytes to form fatty acids and glycerol. These fatty acids and glycerol are eliminated from fat cells by passive diffusion, transported across the cell membrane via protein transporters and are ultimately shuttled into the bloodstream to be expensed as fuel by other cells and tissues.
I speculate that the effects I have seen so far in the course of taking Patented Anabolic are due to a combination of direct anabolic effects (possibly due to hormonal modulation), beta-adrenergic effects, as well as cyclic-AMP-mediated effects.
Recall that 3,5 cyclic adenosine monophosphate (cAMP) is the messenger for beta adrenoceptors. Increased cAMP levels are known to, for instance, stimulate lipolytic activity, trigger the levels of a Leydig-cell cholesterol-transfer protein, known as steroidogenic acute regulatory protein (StaR) and steroidogenesis, stimulate the HPTA, inhibit platelet aggregation, improve thyroid function, improve the contractile force of cardiac muscles, boost fat metabolism, and so on. Put differently, cyclic AMP and the host of chemical actions and metabolic processes it activates, together form a complex second messenger system that modulates the intricate and powerful effects of hormones in our body, both lipolytic/anti-catabolic and anabolic.
Now, as is well-known, adrenergic receptors, or adrenoceptors, belong to the G-protein class of coupled receptors, and are the most prominent receptors in the adipose membrane, besides also being expressed in skeletal muscle tissue. These adipose-membrane receptors are classified as either alpha- or beta-adrenoceptors. Although these beta and alpha adrenoceptors share the same messenger, cyclic adenosine monophosphate (cAMP), the specific transduction pathway depends on the receptor type (alpha or beta). The beta adrenoceptors, in particular the beta-2 adrenoceptors, are the most thermogenic and lipolytic, and also induce anabolic effects. In particular, the stimulation of beta-2 adrenoceptors triggers vasodilation in muscle tissue, and promotes oxygen uptake and nutrient transportation to muscle tissue. Furthermore, beta-2 adrenergic receptors are direct thermogenic activators via stimulating direct increases in fatty acid oxidation. Increased oxidation of fatty acids in skeletal muscle cells promotes leaning. To continue, activation of beta-2 adrenoceptors directly upregulates uncoupling proteins 2 and 3 in skeletal muscle cells, leading to enhanced energy expenditure and impairment of the anti-lipolytic effects of alpha-2 adrenoceptors. Overall, the lipolytic and thermogenic beta-adrenoceptors promote the uptake of fatty acids into perixosomes and mitochondria, leading to the oxidation of fats, not carbohydrates, for energy. Furthermore, beta adrenergic stimulation, in particular, tends to exhibit a potential for anabolic activity. The specific anabolic activity of beta-adrenoceptors depends in some cases on the duration of their interaction with receptors in skeletal muscle cells, or whether or not they bypass the liver (thus circumventing first-pass degradation). Examples of anabolic effects from beta-adrenergic stimulation include improved muscle strength, preservation of lean mass (anti-catabolic action), improved nitrogen retention and improved protein synthesis in skeletal muscles (even during caloric restriction).
Patented Anabolic has been incredible so far. It is like I am stacking PowerFULL, Pink Magic, PRIME, and Anabolic Pump! I have experienced and reported solid improvements in different classes as enumerated earlier. After three weeks of Patented Anabolic, I have experienced remarkable cumulative anabolic effects, without any androgenic sides.
The next review will cover Days 22-24. Thank you for following this review!
