REVERSE: Reversing Negatives and Counter-Reversing Positives (IBE-Sponsored)

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  1. Subbed! How I almost missed this one, I have no clue. Always in for some Strat-enlightenment! Awesome log as usual, and your level of knowledge will be invaluable for this type of supplement.


  2. Quote Originally Posted by SokVichet;
    Subbed! How I almost missed this one, I have no clue.....
    Appreciate your company!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
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  3. And they put that crap in so many NO products and protein powders : :

    MAX'S Instantised Post Workout Protein Blend (High GMP Whey Protein Isolate, High Beta-Whey Fraction Whey Protein Isolate, Hydrolysed Whey Protein Isolate), Sucrose, Dextrose, Maltodextrins, Natural and Nature Identical flavours and colours, Creatine Monohydrate, L-Glutamine (0.7%), L-Leucine (0.6%), Taurine, L-Isoleucine (0.2%), L-Valine (0.2%), L-Lysine (0.2%), L-Arginine (0.2%), Vegetable Gum (407), Soy Lecithin, L-Carnitine, Alpha Lipoic Acid, Minerals (Potassium Citrate, Tri Calcium Phosphate, Magnesium Oxide, Ferrous Fumarate, Zinc Sulphate, Potassium Iodide, Sodium Selenite, Chromium Chloride), Vitamins (Vitamin C, Nicotinamide, Vitamin B6, Pantothenic Acid, Riboflavin, Thiamin, Vitamin A Acetate, Folic Acid, Vitamin D3, Biotin, Vitamin B12). Contains Milk Proteins and Soy Lecithin. May contain traces of wheat (from flavours)

    Shock Therapy™ Universal Nutrition
    Total Calories 36
    Dietary Fiber 2 g
    Total Carbohydrates 9 g
    Sugars 0 g
    Selenium (as sodium selenite) 70 mcg
    Vitamin C (as ascorbic acid) 200 mg
    Niacin (as niacinamide) 10 mg
    Vitamin B6 (as pyridoxine HCl) 8 mg
    Vitamin B12 (as cyanocobalamin) 100 mcg
    Sodium 117 mg
    (as sodium bicarbonate and trisodium phosphate)
    Potassium (as potassium phosphate) 59 mg

    Shock Therapy Proprietary Formula 20g
    NO Super Pump Complex
    Arginine AKG
    Citrulline Malate
    Carnosine
    Muscle Volumizing Complex
    Tricreatine Malate
    Betaine Anhydrous
    Glycocyamine
    Nicotinamide Adenine Dinucleotide

    http://msds.chem.ox.ac.uk/SO/sodium_selenite.html

  4. there was a study that I researched two years ago, or so, which claimed a guy in texas(i can't remember exactly where but I think texas uni) but a guy actually dosed trans-res to alleviate lowered lung capacity due to yrs of smoking ... is there any known fact that this can effect gene expression to the extent of reversing carcinogens?
    ---The internet is the father of the electronic lynch-mob---

  5. Quote Originally Posted by hardknock;
    there was a study that I researched two years ago, or so, which claimed a guy in texas(i can't remember exactly where but I think texas uni) but a guy actually dosed trans-res to alleviate lowered lung capacity due to yrs of smoking ... is there any known fact that this can effect gene expression to the extent of reversing carcinogens?
    1) Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations -- Csiszar et al. 294 (6): H2721 -- AJP - Heart and Circulatory Physiology


    Am J Physiol Heart Circ Physiol 294: H2721-H2735, 2008. First published April 18, 2008; doi:10.1152/ajpheart.00235./08 $8.00.

    Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

    Anna Csiszar,1 Nazar Labinskyy,1 Andrej Podlutsky,3 Pawel M. Kaminski,1 Michael S. Wolin,1 Cuihua Zhang,4 Partha Mukhopadhyay,5 Pal Pacher,5 Furong Hu,2 Rafael de Cabo,6 Praveen Ballabh,2 and Zoltan Ungvari1

    Departments of 1Physiology and 2Cell Biology, New York Medical College, Valhalla, New York; 3The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, Texas; 4Departments of Internal Medicine and Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri; 5Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda; and 6Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, Maryland

    Submitted 4 March 2008 ; accepted in final form 15 April 2008


    The dietary polyphenolic compound resveratrol, by activating the protein deacetylase enzyme silent information regulator 2/sirtuin 1 (SIRT1), prolongs life span in evolutionarily distant organisms and may mimic the cytoprotective effects of dietary restriction. The present study was designed to elucidate the effects of resveratrol on cigarette smoke-induced vascular oxidative stress and inflammation, which is a clinically highly relevant model of accelerated vascular aging. Cigarette smoke exposure of rats impaired the acetylcholine-induced relaxation of carotid arteries, which could be prevented by resveratrol treatment. Smoking and in vitro treatment with cigarette smoke extract (CSE) increased reactive oxygen species production in rat arteries and cultured coronary arterial endothelial cells (CAECs), respectively, which was attenuated by resveratrol treatment. The smoking-induced upregulation of inflammatory markers (ICAM-1, inducible nitric oxide synthase, IL-6, and TNF-{alpha}) in rat arteries was also abrogated by resveratrol treatment. Resveratrol also inhibited CSE-induced NF-{kappa}B activation and inflammatory gene expression in CAECs. In CAECs, the aforementioned protective effects of resveratrol were abolished by knockdown of SIRT1, whereas the overexpression of SIRT1 mimicked the effects of resveratrol. Resveratrol treatment of rats protected aortic endothelial cells against cigarette smoking-induced apoptotic cell death. Resveratrol also exerted antiapoptotic effects in CSE-treated CAECs, which could be abrogated by knockdown of SIRT1. Resveratrol treatment also attenuated CSE-induced DNA damage in CAECs (comet assay). Thus resveratrol and SIRT1 exert antioxidant, anti-inflammatory, and antiapoptotic effects, which protect the endothelial cells against the adverse effects of cigarette smoking-induced oxidative stress. The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging.
    ------

    Address for reprint requests and other correspondence: Z. Ungvari or A. Csiszar, Dept. of Physiology, New York Medical College, Valhalla, NY 10595 (e-mail: zoltan_ungvari{at}nymc.edu or anna_csiszar{at}nymc.edu)
    2) Resveratrol attenuates cigarette smoking-induced pro-inflammatory alterations in the endothelial phenotype -- Ungvari et al. 22 (1): 747.4 -- The FASEB Journal

    The FASEB Journal. 2008;22:747.4


    Resveratrol attenuates cigarette smoking-induced pro-inflammatory alterations in the endothelial phenotype
    Zoltan Ungvari1, Nazar Labinskyy1, Pal Pacher2, Cuihua Zhang3, Andrej Podlutsky4 and Anna Csiszar1

    1 Department of Physiology New York Medical College, Valhalla, NY
    2 Laboratory of Physiological Studie, NIH/NIAAAs, Rockville, MD
    3 Department of Veterinary Physiology & Pharmacology; Texas A&M University, College Station, TX
    4 The Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX

    ABSTRACT

    Previously we have shown that water soluble components of cigarette smoke (CS) up-regulate NAD(P)H oxidases and activate NF-kB leading to vascular inflammation, likely increasing increased cardiovascular risk in smokers. To determine whether the sirtuin activator resveratrol (RES) protects endothelial cells against the deleterious effects of CS, rats were exposed to the smoke of 5 cigarettes per day (for one week, with or without RES treatment). CS impaired acetylcholine-induced relaxations of carotid arteries, which could be improved by RES treatment. Both smoking and in vitro treatment of coronary arterial endothelial cells (CAECs) with CS extract significantly increased endothelial O2.- production, which were attenuated by RES. Expression of the pro-inflammatory cytokines (IL-1, IL-6 and TNFa) and that of iNOS was significantly increased by CS, which could be attenuated by RES treatment. In CAECs CS treatment elicited NF-kB activation and increased monocyte adhesiveness, which were prevented by RES. Thus, RES at nutritionally relevant concentrations attenuates CS-induced oxidative stress, improves endothelial function and inhibits vascular inflammation.
    3) NCUR Abstract: RESVERATROL, A CONSTITUTE OF RED WINE, INCREASES ANTIOXIDANT LEVELS AND PREVENTS DAMAGE FROM CIGARETTE SMOKE IN HUMAN BRONCHIAL EPITHELIAL CELLS

    RESVERATROL, A CONSTITUTE OF RED WINE, INCREASES ANTIOXIDANT LEVELS AND PREVENTS DAMAGE FROM CIGARETTE SMOKE IN HUMAN BRONCHIAL EPITHELIAL CELLS


    Albert Shih, Hongqiao Zhang, Alessandra Rinna, Henry Jay Forman University of California at Merced, Merced, CA95343

    Resveratrol is a compound that exists in grape skin and red wine and has been suspected to be responsible for the beneficial effects of red wine. However, the mechanism underlying these beneficial effects still need to be further identified. In this study, we investigated the effects of resveratoral on the antioxidant (glutathione) level and its potential protection of cigarette smoking in lungs. Glutathione is the master antioxidant that maintains the redox homeostasis and is critical to protect lungs from damage caused by xenobiotics including cigarette smoke and other airborne toxins. We first found that resveratrol dose-dependently increased glutathione levels in human lung epithelial cells. To define the mechanism, we determined the mRNA levels of the catalytic and modulator subunits of glutamate cysteine ligase (GCL), the rate limiting enzyme for glutathione synthesis, and found resveratrol increased the mRNA levels of both subunits. We then checked if resveratrol could protect bronchial cells from damage caused by cigarette smoking. resveratrol eliminated the lipid peroxidation level caused by cigarette smoking extract (CSE), and furthermore, it prevented cell death caused CSE exposure. Moreover, the protective effects of resveratrol on CSE was abrogated by L-buthionine-(S,R)-sulfoximine (BSO), a specific inhibitor of GCL. Our data suggest that resveratrol could increase the antioxidant level in the human bronchial epithelial cells and thus potentially prevent harmful effects caused by cigarette smoking and other air pollutants.
    Product Educator | USPowders
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  6. Good info, Ike!

    Evolutionary Muse - Inspire to Evolve
    Legendary


  7. Quote Originally Posted by Trauma1;
    Good info, Ike!
    Thanks, J!
    Product Educator | USPowders
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  8. Man, strat is coming up with even more amazing studies than I read on a daily basis. I remember the part of lung capacity, and even improvement in lung cancer.

    Adams
    The Historic PES Legend

  9. Quote Originally Posted by Trauma1 View Post
    Good info, Ike!

    Ike ?? , as in Hurricane Ike or as in Tina Turner ?? Just kidding!

    Strategic,

    have you tried stoked? Which product has the better bioavailability and why, Stoked or Reverse. What product do you recommend, or is it too early to tell??

    Thanks.

  10. Read his STOKED! log... it's a great read!
    Getting Your Anabolic Furnace STOKED! (Sponsored)
    And I can't (or won't) speak for Ike, but I believe it may in fact, be too early to compare the two. And plus, our Reverse is set up differently than STOKED! If you notice, it is more of a staple supplement compared to the latter.

    Quote Originally Posted by Imeniaan View Post
    Ike ?? , as in Hurricane Ike or as in Tina Turner ?? Just kidding!

    Strategic,

    have you tried stoked? Which product has the better bioavailability and why, Stoked or Reverse. What product do you recommend, or is it too early to tell??

    Thanks.

  11. Quote Originally Posted by Iron Lungz View Post
    Read his STOKED! log... it's a great read!
    Getting Your Anabolic Furnace STOKED! (Sponsored)
    And I can't (or won't) speak for Ike, but I believe it may in fact, be too early to compare the two. And plus, our Reverse is set up differently than STOKED! If you notice, it is more of a staple supplement compared to the latter.
    Thanks, Iron!

    Quote Originally Posted by Imeniaan View Post
    Ike ?? , as in Hurricane Ike or as in Tina Turner ?? Just kidding!

    Strategic,

    have you tried stoked? Which product has the better bioavailability and why, Stoked or Reverse. What product do you recommend, or is it too early to tell??

    Thanks.
    Imeniaan, I fully agree with Iron. REVERSE and STOKED! were designed with different objectives in mind, so a direct comparison may not be accurate. Both are excellent products.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  12. Quote Originally Posted by strategicmove View Post
    Thanks, Iron!



    Imeniaan, I fully agree with Iron. REVERSE and STOKED! were designed with different objectives in mind, so a direct comparison may not be accurate. Both are excellent products.
    Agreed. STOKED is aimed at the testosterone boosting effects, with the bioavail enhancers you get a SIRT1 suppression. With Reverse, we are aiming for the SIRT1 expression, which is why we acytilated it. When you ingest Reverse, the acytilation causes hydrolysis, essentially making the ester a coat of armor, removed for pure unadulterated Resveratrol.

    Okay... I hope all that makes sense... I have 3 cups of Kava Kava in me... so things are a little fuzzy.

    Adams
    The Historic PES Legend

  13. I was wondering if you're getting any lethargy shortly after dosing? I'm using four cap of Reverse before bed and have been getting awesome sleep with it. It cleared up my skin which was breaking out from Diesel Test Hardcore and seems to have balance my mood substantially.

  14. Quote Originally Posted by slow-mun View Post
    I was wondering if you're getting any lethargy shortly after dosing? I'm using four cap of Reverse before bed and have been getting awesome sleep with it. It cleared up my skin which was breaking out from Diesel Test Hardcore and seems to have balance my mood substantially.
    No, I have not experienced lethargy immediately post-REVERSE intake. I always make sure, though, I take a capsule last thing before bed daily. I usually add one tablet (1000mg) of a Vitamin -C supplement (actually a blend of 1000mg Vitamin C plus 10mg of Dihydroquercetin). I take this vitamin-c supplement with REVERSE, only because resveratrol helps recycle vitamin c (just like dihydroquercetin does).

    Is there any particular reason you take four capsules of REVERSE at once, and not split them into two servings?
    Product Educator | USPowders
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  15. October 17, 2008 - October 20, 2008
    Days 14 - 17


    Results:

    The past couple of days have seen a continuation of sustained feelings of well-being (this aspect may be due to resveratrol, similar to rhodiola rosea, beneficially impacting levels of serotonin, norepinephrine, and endogenous feel-good opioids such as beta-endorphins). Vasodilation/vascularity, physical and mental endurance, as well as excellent motor function remain at high levels. Furthermore, the enhanced immune-system strength and immune response have played an important role in keeping me symptom-free in the current flu-season. REVERSE has been quite impressive so far, and I am enjoying every single day on it!
    Product Educator | USPowders
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  16. You should consider teaching as a job strag

  17. Quote Originally Posted by strategicmove View Post
    No, I have not experienced lethargy immediately post-REVERSE intake. I always make sure, though, I take a capsule last thing before bed daily. I usually add one tablet (1000mg) of a Vitamin -C supplement (actually a blend of 1000mg Vitamin C plus 10mg of Dihydroquercetin). I take this vitamin-c supplement with REVERSE, only because resveratrol helps recycle vitamin c (just like dihydroquercetin does).

    Is there any particular reason you take four capsules of REVERSE at once, and not split them into two servings?
    I'm taking resveratrol twice a day already. Reverse is my bedtime dose and four caps seems to make me pretty lethargic. Truth be told, my decent results didn't begin until I added Reverse. The other resveratrol product has been used for about two months with little results.

  18. Quote Originally Posted by Steveoph View Post
    You should consider teaching as a job strag
    I doubt that would be a strategic move!
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  19. Quote Originally Posted by slow-mun View Post
    I'm taking resveratrol twice a day already. Reverse is my bedtime dose and four caps seems to make me pretty lethargic. Truth be told, my decent results didn't begin until I added Reverse. The other resveratrol product has been used for about two months with little results.
    REVERSE is it!
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  20. Thank you sir for the excellent info! I just ordered my first bottle from NP. I'm going to run it the same way for 25 days.

  21. Quote Originally Posted by eros62d View Post
    Thank you sir for the excellent info! I just ordered my first bottle from NP. I'm going to run it the same way for 25 days.
    That's good to hear. Keep us updated on your progress!

  22. Quote Originally Posted by eros62d View Post
    Thank you sir for the excellent info! I just ordered my first bottle from NP. I'm going to run it the same way for 25 days.
    Same here, put an order a few days ago, if Strategic thinks Reverse is than there's no further debate about it

  23. I think I'm gonna give this a try also in 2 months or so when I run out of my current supplies. Thinking of stacking this with a GH booster (x-dream?) and some RPN products for a "rejuvenation stack" to run for 3 months or so..

  24. Quote Originally Posted by eros62d View Post
    Thank you sir for the excellent info! I just ordered my first bottle from NP. I'm going to run it the same way for 25 days.
    Awesome! In fact, you can stay on one capsule a day maintenance afterwards.
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  25. Quote Originally Posted by dragonfly View Post
    Same here, put an order a few days ago, if Strategic thinks Reverse is than there's no further debate about it
    Product Educator | USPowders
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