I've seen a couple mentions on the forum's here about taking Epistane stacked with DHEA- what is the advantage of that, and what dosage should the DHEA be at? Also, what is the advantage of a cortisol blocker with PCT?
DHEA was recommended to me by dsade to help with shutdown after using epi or havoc. I used it during pct since i was already done with my cycle and it helped immensely but it will also help avoid shutdown while on.
After a cycle, high cortisol levels are experienced which can wreak havoc on your newly established gains. Anti cort=anti catabolic=better gain retention. I've seen DHEA taken with epistane pulse cycles taken on off days in effort to avoid any rebound effects from skipping days on.
Thanks guys, what dosage of DHEA should be used on cycle? How about during post cycle therapy? Also, should I use a cort blocker during my cycle?
I liked 100mg for 3 weeks and 150mg for the last week OK. It was strange, the 1st 2 weeks of havoc/DHEA my libido was great (also using RPM at the time). The last 2 weeks werent as great, even with the increased dose on the last week. Seems like once the havoc really kicked in, the libido boost went bye-bye. I may try 200mg next time with Epistane.
Thanks, I will be taking Retain 2 for my cort blocker and Diesel test hardcore for my post cycle therapy.
I'm on a pulse cycle right now and I take 25-50mg of DHEA on off-days. I'm 5 weeks into the pulse cycle and really haven't experienced any negative sides.
No gyno or symptoms at all. Gyno has never been an issue for me though.
Why are you experiencing the gyno symptoms? Epi blocks estrogen. Do you think DHEA is causing gyno symptoms?
Well I'm doing a pulse and my guess is that the fluctuation of hormones between on and off days is causing the gyno, not the compound itself.
And no, DHEA is not causing it because I just started it.
Kalimi et al. 1994)."
How did you run the pule? I just got my bottle of havoc and i was thinking of doing..
10/20/30, 100mg DHEA off days
30/30/30, 200mg DHEA off days
30/30/30, 200mg DHEA off days
40/40/40, 200mg DHEA off days
im debating on using ATD or Fromastane on off days, but epi it self is a strong AI.
Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant.
Calhoun KE, Pommier RF, Muller P, Fletcher WS, Toth-Fejel S.
Department of General Surgery, Oregon Health and Sciences University, Portland, OR 97201, USA.
HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) causes a proliferation of estrogen receptor (ER)-positive breast cancer cells, even with tamoxifen citrate blockade. The ER antagonist ICI 182780 (fulvestrant) will more effectively stop the proliferative effect of DHEA-S on breast cancer cells. DESIGN: Examination of in vitro breast cancer cell growth in the presence of fulvestrant and DHEA-S. SETTING: Surgical oncology research laboratory. INTERVENTIONS: The ER-positive and ER-negative breast cancer cells were pretreated with fulvestrant and stimulated with 900 microg/dL (22.8 micromol/L) of DHEA-S. MAIN OUTCOME MEASURES: Assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltet
razolium bromide, thiazolyl blue, were performed on the third, fifth, and seventh days poststimulation and permitted the calculation of growth percent change. RESULTS: The ER-positive and progesterone receptor-positive cells demonstrated universal proliferation of 107% by day 7 when treated with fulvestrant, regardless of the dose. The ER-negative and progesterone receptor-negative cells demonstrated growth inhibition. CONCLUSIONS: The DHEA-S circumvented fulvestrant inhibition and caused ER-positive breast cancer cell growth.