DHEA & Epistane?

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  1. Question DHEA & Epistane?


    I've seen a couple mentions on the forum's here about taking Epistane stacked with DHEA- what is the advantage of that, and what dosage should the DHEA be at? Also, what is the advantage of a cortisol blocker with PCT?


  2. DHEA was recommended to me by dsade to help with shutdown after using epi or havoc. I used it during pct since i was already done with my cycle and it helped immensely but it will also help avoid shutdown while on.
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  3. After a cycle, high cortisol levels are experienced which can wreak havoc on your newly established gains. Anti cort=anti catabolic=better gain retention. I've seen DHEA taken with epistane pulse cycles taken on off days in effort to avoid any rebound effects from skipping days on.

  4. Thanks guys, what dosage of DHEA should be used on cycle? How about during post cycle therapy? Also, should I use a cort blocker during my cycle?

  5. Bump. Anybody?
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  6. I liked 100mg for 3 weeks and 150mg for the last week OK. It was strange, the 1st 2 weeks of havoc/DHEA my libido was great (also using RPM at the time). The last 2 weeks werent as great, even with the increased dose on the last week. Seems like once the havoc really kicked in, the libido boost went bye-bye. I may try 200mg next time with Epistane.

  7. Quote Originally Posted by mountainboy View Post
    Thanks guys, what dosage of DHEA should be used on cycle? How about during post cycle therapy? Also, should I use a cort blocker during my cycle?
    I don't think you should need to use a cort blocker during cycle, my understanding for the DHEA was to assist with libido/easing shutdown. The anabolic/androgenic effects of the hormone you are taking should be keeping cort low on it's own anyway. PCT, make sure you have a good cort blocker though.

  8. Thanks, I will be taking Retain 2 for my cort blocker and Diesel test hardcore for my post cycle therapy.

  9. I'm on a pulse cycle right now and I take 25-50mg of DHEA on off-days. I'm 5 weeks into the pulse cycle and really haven't experienced any negative sides.

  10. Quote Originally Posted by edvanp View Post
    I'm on a pulse cycle right now and I take 25-50mg of DHEA on off-days. I'm 5 weeks into the pulse cycle and really haven't experienced any negative sides.
    Yeah, the reseach I've done seems to show that taking Epi with DHEA lowers sides during and after- good luck on your cycle.

  11. Quote Originally Posted by mountainboy View Post
    Thanks, I will be taking Retain 2 for my cort blocker and Diesel test hardcore for my post cycle therapy.
    DTH is the only thing your taking after your cycle for a pct...............

  12. Quote Originally Posted by Frequency View Post
    DTH is the only thing your taking after your cycle for a post cycle therapy...............
    No, I will also be using a SERM. I have been looking into advanced PCT as well, I'm not sure if I will get that though.

  13. Quote Originally Posted by mountainboy View Post
    No, I will also be using a SERM. I have been looking into advanced post cycle therapy as well, I'm not sure if I will get that though.
    Awsome. I was like **** not another one lol

  14. Quote Originally Posted by edvanp View Post
    I'm on a pulse cycle right now and I take 25-50mg of DHEA on off-days. I'm 5 weeks into the pulse cycle and really haven't experienced any negative sides.
    Have you experienced any gyno symptoms at all?

    I'm on my third week of a pulse and notice a little gyno symptoms. I'm thinking it's the bounceback effect on the offdays that's causing it. Adding DHEA seems like it would be a good idea to blunt the bounceback symptoms.

  15. No gyno or symptoms at all. Gyno has never been an issue for me though.

  16. Why are you experiencing the gyno symptoms? Epi blocks estrogen. Do you think DHEA is causing gyno symptoms?

  17. Well I'm doing a pulse and my guess is that the fluctuation of hormones between on and off days is causing the gyno, not the compound itself.

    And no, DHEA is not causing it because I just started it.

  18. Quote Originally Posted by mountainboy View Post
    Thanks guys, what dosage of DHEA should be used on cycle? How about during post cycle therapy? Also, should I use a cort blocker during my cycle?
    i believe dr.d recommended 200mg DHEA on off days, during the pulse cycle. "DHEA is an ACTH-regulated steroid that possesses anti-glucocorticoid properties (Kalimi et al. 1994)."


    How did you run the pule? I just got my bottle of havoc and i was thinking of doing..

    10/20/30, 100mg DHEA off days
    30/30/30, 200mg DHEA off days
    30/30/30, 200mg DHEA off days
    40/40/40, 200mg DHEA off days

    im debating on using ATD or Fromastane on off days, but epi it self is a strong AI.

  19. Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant.
    Calhoun KE, Pommier RF, Muller P, Fletcher WS, Toth-Fejel S.
    Department of General Surgery, Oregon Health and Sciences University, Portland, OR 97201, USA.

    HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) causes a proliferation of estrogen receptor (ER)-positive breast cancer cells, even with tamoxifen citrate blockade. The ER antagonist ICI 182780 (fulvestrant) will more effectively stop the proliferative effect of DHEA-S on breast cancer cells. DESIGN: Examination of in vitro breast cancer cell growth in the presence of fulvestrant and DHEA-S. SETTING: Surgical oncology research laboratory. INTERVENTIONS: The ER-positive and ER-negative breast cancer cells were pretreated with fulvestrant and stimulated with 900 microg/dL (22.8 micromol/L) of DHEA-S. MAIN OUTCOME MEASURES: Assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltet
    razolium bromide, thiazolyl blue, were performed on the third, fifth, and seventh days poststimulation and permitted the calculation of growth percent change. RESULTS: The ER-positive and progesterone receptor-positive cells demonstrated universal proliferation of 107% by day 7 when treated with fulvestrant, regardless of the dose. The ER-negative and progesterone receptor-negative cells demonstrated growth inhibition. CONCLUSIONS: The DHEA-S circumvented fulvestrant inhibition and caused ER-positive breast cancer cell growth.

  20. Quote Originally Posted by Deccadick View Post
    Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant.
    Calhoun KE, Pommier RF, Muller P, Fletcher WS, Toth-Fejel S.
    Department of General Surgery, Oregon Health and Sciences University, Portland, OR 97201, USA.

    HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) causes a proliferation of estrogen receptor (ER)-positive breast cancer cells, even with tamoxifen citrate blockade. The ER antagonist ICI 182780 (fulvestrant) will more effectively stop the proliferative effect of DHEA-S on breast cancer cells. DESIGN: Examination of in vitro breast cancer cell growth in the presence of fulvestrant and DHEA-S. SETTING: Surgical oncology research laboratory. INTERVENTIONS: The ER-positive and ER-negative breast cancer cells were pretreated with fulvestrant and stimulated with 900 microg/dL (22.8 micromol/L) of DHEA-S. MAIN OUTCOME MEASURES: Assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltet
    razolium bromide, thiazolyl blue, were performed on the third, fifth, and seventh days poststimulation and permitted the calculation of growth percent change. RESULTS: The ER-positive and progesterone receptor-positive cells demonstrated universal proliferation of 107% by day 7 when treated with fulvestrant, regardless of the dose. The ER-negative and progesterone receptor-negative cells demonstrated growth inhibition. CONCLUSIONS: The DHEA-S circumvented fulvestrant inhibition and caused ER-positive breast cancer cell growth.
    ouch, so DHEA can aid in gyno? but epi itself is a strong AI and should prevent it.

  21. I guess everyone is unsure at this point. Dr. D states that he has used it for years without any gyno problems. But most of the research states it may cause gyno. But I haven't seen a study done on bodybuilders, which is what we really need to see. I am currently using coleus F. Forslean. and am experiencing some itchy, and sensitive nipples from the stuff. So I am obviously very susceptible to gyno. But then again I have a high percentage of bodyfat at this time, so this probably causes more estrogen problems.

  22. Quote Originally Posted by Deccadick View Post
    I guess everyone is unsure at this point. Dr. D states that he has used it for years without any gyno problems. But most of the research states it may cause gyno. But I haven't seen a study done on bodybuilders, which is what we really need to see. I am currently using coleus F. Forslean. and am experiencing some itchy, and sensitive nipples from the stuff. So I am obviously very susceptible to gyno. But then again I have a high percentage of bodyfat at this time, so this probably causes more estrogen problems.
    I am on day 9 of halo-tren400 and have been taking rawtest (DHEA and pregnalone) 5on 2 off w/my cycle. I will bridge into epi on week 4 and once the raw test runs out, I plan to use Dermacrine. So far no gyno issues to report (I have high bf as well, I think it just matters about your genes)

  23. I agree.

  24. Quote Originally Posted by mountainboy View Post
    I am on day 9 of halo-tren400 and have been taking rawtest (DHEA and pregnalone) 5on 2 off w/my cycle. I will bridge into epi on week 4 and once the raw test runs out, I plan to use Dermacrine. So far no gyno issues to report (I have high bf as well, I think it just matters about your genes)
    Do tell, after my epi pulse, I will take time off and post cycle therapy. Then I was really looking at halotren400....looks good! I have lowish bf 10-11 and have never really had any issues with gyno even when I was ass ten years ago and took high dose andro, then high dose 5ad with NO post cycle therapy. But gyno is a wierd beast, now of course being far more educated and many years of chemistry and study later, I am very careful..........CRIKEY!
    Last edited by cromwell; 10-06-2007 at 01:48 PM. Reason: paranoia

  25. Quote Originally Posted by cromwell View Post
    Do tell, after my epi pulse, I will take time off and post cycle therapy. Then I was really looking at halotren400....looks good! I have lowish bf 10-11 and have never really had any issues with gyno even when I was ass ten years ago and took high dose andro, then high dose 5ad with NO post cycle therapy. But gyno is a wierd beast, now of course being far more educated and many years of chemistry and study later, I am very careful..........CRIKEY!
    Well as far as the Halo-tren 400 I am on my 12th day, I don't really have alot to report- it hasn't seemed to do anything for me yet (I have heard that it takes between 10days and 3 weeks) I started the first week w/2ED on the second week I went to 3ED during the third week I will bump up to 4ED, I'm not sure if I will up my dose anymore than that for the fourth week. I am taking in about 2400- 2500 cals a day w/ ~250 grams protein 45p/35c/20f. I am trying to cut on this cycle. I hope it starts kicking in soon.
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