made2last
Member
- Awards
- 0
Has anyone used progesterone creams? What were your results?
It is quite interesting. It can form anything depending on the enzyme availability in your cells. It is the precursor to androgens (minus cholesterol of course). I found it interesting how cleavage just a few bonds results in DHt then another results in testosterone. ****ing love science.Everything stems from pregnenolone, but there is no way to determine the pathway it takes and sometimes pregnenolone steal occurs and converts to high levels of prog and cort and low levels of DHEA, so supplementation is needed. Personally, I'd never start adding in prog or any additional hormones without knowing where you stand to begin with because at that point it is just a chasing game.
Currently on derma at 4 pumps daily. Seems like good stuff. I'd rather have some type of DHT derivative but whatever.Lex I haven't tried dermacrine but it looks interesting. The difference between a transdermal and oral versions of the same pro hormone can be like night and day!
7 weeks now and I've used it in previous cycles.Eatmoar - have you been using it long? I'd definitely like to try it out myself, though it looks like it will take a few weeks to get here from US suppliers.
Would it be worth it to use now brand cream as a standalone?I've used it as a Now brand cream at 20mg per day. First thing, it makes you feel really calm. I have noted more vascularity. Estrogen tends to make me flush and the cream stopped that flushing and seemed to improve the texture and elasticity of my skin. Looking at a steroid pathway chart, progesterone has a number of options of conversion beyond it's one direct cellular effects. So, I think it would be difficult for anyone to make a pan statement on it's effects without knowing details of the plasma or saliva levels of many other endogenous hormones at the same time. There are a number of websites clearly advocating progesterone cream , some at up to 100mg a day for males which does seem rather excessive. They do site studies to support their claims, but I imagine there are other studies out there conflicting with their assertions. I have found that a little progesterone cream with some testosterone gel makes me feel great. Interestingly, all my various trt attempts in various forms and doses did not boost libido, but the low dose combo with progesterone definitely did. Is some converting to testosterone or androstenedione? It's possible. Several studies clearly point to progesterone being THE hormone of libido, not testosterone, though clearly they require suitable levels of each other for optimum function. The brilliant endo and biologist Ray Peat advocates progesterone only treatment for men over sixty and he has published an extensive body of work on it's life extending, anti inflammatory powers. He also tested it on himself at supraphysiological doses without sides and it certainly didn't shut him down. Personally, well under the 60 bracket, I think it's something one has to try small amounts of and gauge their own responses. As for blood tests - that would be great if everybody had a blood profile on their 18th birthday, then they would know what to aim for. I'm convinced that many guys out there probably have odd combinations of hormones at 18, which due to genetics, work for them. I wish I had profiled at that age - but it's the very last thing you think about then! Many athletes and physicians advocate pregnenolone for men, rather than progesterone. The thing is, nobody knows what way preg will go once it's in the system... Cortisol? Aldosterone? Testosterone? Progesterone is a step along the chain and it may all stay in that form effecting what prog is supposed to - like inflammation and regenerative functions. I do know it is pro thyroid and anything that supports thyroid is a big issue because even a mild hypo condition can set up a cascade of degenerative failures. Anyway, these are my opinions and experiences and I hope they contribute to the debate
From all the articles and posts I've read, I wouldn't touch progesterone cream with a 10ft pole. I've read posts of guys saying they've had a dead dick for 6+ months after using a bit of progesterone cream every day for a couple weeks. Scary sh-tPerhaps the missing link to DHT's failure to guarantee libido is progesterone? There are guys on here and other forums with sky high DHT and no libido to speak of, as well as those with E within range experiencing the same. This article provides a balanced TRT viewpoint I think: http://www.peaktestosterone.com/Progesterone_Erectile_Dysfunction.aspx
No there is no confusion.Ummm... I think a lot of the people who are confused here might be getting progesterone confused with prolactin. One definitely causes ED (prolactin) which tends to be elevated when you have high levels of progesterone which suddenly drop (hence the leaky nips when you stop 19-nors), progesterone does not cause ED and may cause the opposite, but that doesn't mean its a good idea to add a lot of exogenous progesterone because when you come off.... hello elevated prolactin.
It is easy to find what you want to hear. The point is, you will be very hard pressed to find endos or hormone therapists that would agree with men taking progesterone unless they were deficient and even then, the first step is pregnenolone supplementation. I've had this discussion with many people in this industry and it is universally agreed that they would not go this route unless needed. My father's urologist said that they have looked into this for prostate cancer therapy, but even they do not feel comfortable with recommending it.Perhaps the missing link to DHT's failure to guarantee libido is progesterone? There are guys on here and other forums with sky high DHT and no libido to speak of, as well as those with E within range experiencing the same.
This article provides a balanced TRT viewpoint I think:
http://www.peaktestosterone.com/Progesterone_Erectile_Dysfunction.aspx