One thing that I can say I have experienced in my injecting is in my quads. On my 1test cyp/4ad cyp cycle I was using my quads,glutes, and delts. Now for my quads, I NEVER could get the needle in my left leg without hitting a nerve, that is out of 8-10 tries, that was alot of sharp pains lol. I hit a couple nerves in my right quad but not as much of a problem as I had with my left leg. Now even 3 months after that cycle, my upper outer portion of my quad where I was injecting is definetly noticeably bigger. When I look in the mirror looking at a side view, my right quad has a much greater sweep to it than my left, my right quad is also ~.75-1in bigger than my left, it has always been around .25-.5in bigger, but the difference is much bigger now. That is just in my experience of injecting one site and comparing it to another site that was not being injected. I do think there is some merit to this, but not really much, and definetly not enough to justify injecting calves, although base hormones have a better chance of actually increasing the site since they are active the instant they are in. From my experience, draw your own conclusions.