[Trauma1]

NoXidant (90 Capsules)


-Eliminate free radicals.
-Promote anabolism.
-Optimize nitric oxide.


NOxidant is a potent blend of antioxidants specifically designed to counteract reactive nitrogen species - harmful free radicals produced from nitric oxide. NOxidant is best used in conjunction with nitric oxide enhancing supplements such as arginine and citrulline malate. Taken post-workout, NOxidant can protect the body from reactive nitrogen species to ensure an optimal anabolic environment and maximize your results.



Supplement Facts
Serving Size: 3 Capsules
Servings per Container: 30

Amount Per Serving % Daily Value
Gamma-Tocopherol 500 mg **
Selenium (yeilding 200 mcg Selenium) 100 mg **
Alpha Lipoic Acid 100 mg **
Grape Seed Extract 200 mg **
Green Tea Extract (50%) 300 mg **
Quercetin 200 mg **
Apple Polyphenols 300 mg **
Zinc Aspartate (20%) (standardized to 10 mg zinc) 50 mg **
Copper Gluconate (20%) (yielding 100 mcg copper) 500 mcg **
Manganese Chelate-(20%) (yielding .2 mg Manganese) 1 mg **
Vitamin C 250 mg **

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.


OTHER INGREDIENTS: Dicalcium phosphate, gelatin and silicon dioxide.


Directions:
As a dietary supplement, take 3 capsules daily. On training days, take one serving post-workout and on non-training days take one serving before breakfast.


Pick up your NOxidant today at the one and only Nutraplanet!

RPN's NOxidant at Nutraplanet






RPN's NOxidant Q&A Summary:


Q: What are free radicals and how do they form?

A: By definition a free radical is any atom (I.E. oxygen, nitrogen) with at least one unpaired electron in the outermost shell. Before we go any further, here's a very brief summary of what an atom is.

An atom contains a nucleus made up of protons(positively charged particles) and neutrons(electrically neutral particles). Circling around the outside of this nucleus are pairs of electrons(negatively charged particles.)

A free radical is easily formed when a covalent bond(sharing of electrons between atoms) is broken and one electron remains with each newly formed atom. Free radicals are highly reactive due to the presence of unpaired electron(s). So essentially, these newly formed free radical(s) will do anything in their power to steal any nearby electron(s) to stabilize themselves. This includes stealing electrons from nearby stable healthy cells damaging them greatly over time. This can lead to a chain reaction of free radical development.

There are certain types of activities/foods/situations that can increase the opportunity of free radical formation. (I.E. smoking, pollution, high fat and sugar diets.) As you all may have guessed by now, bodybuilding/training/exercise can also greatly increase free radical formation. This is mainly due to increased stress and oxygen intake leading to increased free radical formation.


Q: What are Antioxidants and how do they work?

A: Antioxidants by definition are any substance(s)that slow or prevent the oxidation process. Antioxidants work by donating an electron to these unstable free radical(s) stabilizing them. This can then in turn prevent the possibility of a chain reaction of free radical development. This can result from the excessive free radical formation in the absence of sufficient antioxidants which help prevent them.

After donating an electron an antioxidant also becomes a free radical in itself by definition. Antioxidants in this state are not harmful because they have the ability to accommodate the change in electrons without becoming reactive or harmful however.

There are many different types of antioxidants overall. Our body can synthesize some of them, however many of the necessary antioxidants must be taken in through a proper diet and supplementation program. The key here is to restore the balance within the body and keep free radicals in check, not completely eliminate them. Free radicals also attack germs within the body, they don't solely attack healthy normal cells.


Q: How can proper Antioxidant intake assist me in my training and muscle gains?

A: When we workout there is an increase in free radical formation within our bodies. If this free radical formation begins to rise faster than it's being neutralized, you can fall victim to what is known as oxidative stress. This can cause you to feel very tired, have poor training endurance, make you more prone to training injuries, and cause a lowered immune response leading to frequent illness. This oxidative stress is not very conducive to a successful diet, supplementation, and training program.

By ingesting the proper Antioxidants post-workout, you can help limit the amount of oxidative stress and maintain a more anabolic environment......something many of us all strive to attain each day.

RPN has designed a product that will provide very effective Antioxidant protection and assist in your overall training goals.



Enter RPN's NOxidant(See product ingredient profile and description above)



Q: What is Nitric Oxide?

A: Nitric Oxide (nitrogen monoxide, NO)

Nitric oxide, a colorless, toxic, non-flammable gas, is the most stable nitrogen oxide. This is chemically interesting since the molecule is paramagnetic (has an unpaired electron). This unshared electron makes the NO molecule highly reactive.

In animals, nitric oxide is a neurotransmitter implicated in mediating a number of physiological processes including relaxation of smooth muscles, inhibition of platelet aggregation, increasing kidney filtration and urine production, penile erection (Viagra works by generation of NO), and inhibition of inflammation. Since it is a gas, it rapidly diffuses through the cell to its site of biological activity. But, since it is highly reactive, it is rapidly inactivated.

NO is generated in the body by the reaction of an enzyme Nitric Oxide Synthetase (NOS) in the reaction

Arginine + O2 ===> Citrullene + NO


There are two importance items to notice about this reaction:

1. Oxygen, not nitrogen is the gaseous component of the reaction

2. An increase in pO2 will drive the reaction to the right (Le Chateliers Principle) and produce more NO.


This suggests that the sharp threshold of oxygen toxicity at depth may be related to NO (a very reactive oxidizing agent). In other words, increasing pO2 will produce an increasing excess of an excitatory neurotransmitter. The body has a variety of defense mechanisms to remove or inactivate highly reactive oxidizers (like NO), but eventually, too much NO would overwhelm protective mechanisms. So, a simplistic way of conceptualizing an oxygen toxicity hit, is to view CNS oxygen toxicity as overwhelming the bodies defenses with too much oxidative, excitatory neurotransmitters.


Finally, some other NO factoids:


Nitroglycerin used in reducing angina attack works by generating NO which leads to pain-relieving heart muscle vasodilatation.


Nitric oxide is implicated in the initiation of firefly light emission.


Nitric oxide has been used in the treatment of surgical pulmonary embolisms. Its vasodilatation ability reduces blood pressure in the lungs.


Nitric oxide is a common component of automobile pollution. It is a primary component in photochemical smog.


Because of its chemical properties, the molecule often dimerizes to form N2O2.



Q: When is the proper time of day to take NOxidant?

A: This largely depends upon if it's a training day or not. On training days we recommend that you take (3)capsules preferably before bed at night to combat the excessive formation of training induced free radical formation. Taking this before bed at night allows ample time for training induced free-radical formation to act upon cellular/muscle damage, and allowing for cell signaling to occur.(which is very beneficial leading to better gains). However, if this free radical chain reaction process is allowed to continue, the damage will eventually outweigh the benefits. Much research supports taking the dosing before bed to help limit the free radical cascade or chain reaction from getting to the negative point of compromising gains, instead of enhancing them.

This product provides your body with very effective Antioxidant protection to further enhance your overall training induced stimulation and recovery processes leading to better overall results.

On non-training days, we recommend you take NOxidant first thing in the morning. Dosing would be (3)capsules upon rising in the a.m.


Q: What kind of overall results can i expect with using NOxidant?

A: NOxidant provides a very potent blend of necessary Antioxidants most of which are very specific in treating free radical formation resulting from the reactive nitrogen species which is very destructive to our bodies.

During intense weight training, NO(nitric oxide) is synthesized by the body and free radical formation results as by-products of aerobic metabolism. NOxidant is specifically designed to protect you from this destructive free radical process post workout. NOxidant can provide you with the following overall training/health benefits:

-A quicker recovery time
-Enhanced overall muscle gains/results
-Increased training endurance
-A strengthened immunologic state
-Help prevent precipitant cellular aging/death
-Improved NO(NITRIC OXIDE) utilization


Q: What are some supplements that would be effective to stack with NOxidant?

A: RPN has put together a very specific stack with Nimbus Nutrition called "The Rejuvenation stack." This stack contains the supplements, NOxidant, Gut Health, and Poseidon. Together this combination of very effective and synergistic supplements enhance all of the benefits we've already described above. It's the ultimate way to rejuvenate your body back into a healthy and anabolic state. Get this stack at the one and only nutraplanet!!

NOxidant also works very well with NO(nitric oxide) enhancing supplements and citruilline malate. It will potentiate their effects for even better results overall.

NOxidant can greatly enhance all of your training and health goals at a very affordable price. Don't delay your potential progress any longer, add NOxidant into your supplementation regime to assist in the formation of the NEW AND IMPROVED you!!

[3clipseGT]

This is in my shopping cart as we speak!

Originally Posted by Trauma1

NoXidant (90 Capsules)


-Eliminate free radicals.
-Promote anabolism.
-Optimize nitric oxide.


NOxidant is a potent blend of antioxidants specifically designed to counteract reactive nitrogen species - harmful free radicals produced from nitric oxide. NOxidant is best used in conjunction with nitric oxide enhancing supplements such as arginine and citrulline malate. Taken post-workout, NOxidant can protect the body from reactive nitrogen species to ensure an optimal anabolic environment and maximize your results.



Supplement Facts
Serving Size: 3 Capsules
Servings per Container: 30

Amount Per Serving % Daily Value
Gamma-Tocopherol 500 mg **
Selenium (yeilding 200 mcg Selenium) 100 mg **
Alpha Lipoic Acid 100 mg **
Grape Seed Extract 200 mg **
Green Tea Extract (50%) 300 mg **
Quercetin 200 mg **
Apple Polyphenols 300 mg **
Zinc Aspartate (20%) (standardized to 10 mg zinc) 50 mg **
Copper Gluconate (20%) (yielding 100 mcg copper) 500 mcg **
Manganese Chelate-(20%) (yielding .2 mg Manganese) 1 mg **
Vitamin C 250 mg **

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.


OTHER INGREDIENTS: Dicalcium phosphate, gelatin and silicon dioxide.


Directions:
As a dietary supplement, take 3 capsules daily. On training days, take one serving post-workout and on non-training days take one serving before breakfast.


Pick up your NOxidant today at the one and only Nutraplanet!

RPN's NOxidant at Nutraplanet

[Trauma1]

Originally Posted by 3clipseGT

This is in my shopping cart as we speak!

Awesome my friend, you're going to love it!

I hope to have a good Q&A up next week for NOxidant also.

[3clipseGT]

Originally Posted by Trauma1

Awesome my friend, you're going to love it!

I hope to have a good Q&A up next week for NOxidant also.

Id expect nothing less from you and RPN my floridian brotha!

[Trauma1]

NOxidant's Q&A is up. More to add shortly, but i figured i'd throw it up anyway.

[crader]

Awesome job T!!

[Trauma1]

Originally Posted by crader

Awesome job T!!

Thanks C.

[OCCFan023]

Great write up T. Like the additional Q&A.

Maybe you could even video tape yourself and send it to Sam at NP and it could be a NPtv addition . lol j/p

[Trauma1]

Here's a very interesting abstract that makes a good addition:

Generation of Reactive Oxygen and Nitrogen Species in Contracting Skeletal Muscle
Potential Impact on Aging

MICHAEL B. REID11Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA AND WILLIAM J. DURHAM11Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA1Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Address for correspondence: Michael B. Reid, Ph.D., Pulmonary Medicine, Suite 520B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Voice: 713-798-7224; fax: 713-798-3619. reid@bcm.tmc.edu.
Abstract

Abstract:
Since the early 1980s biologists have recognized that skeletal muscle generates free radicals. Of particular interest are two closely related redox cascades—reactive oxygen species (ROS) and nitric oxide (NO) derivatives. The ROS cascade is initiated by superoxide anion radicals derived from the mitochondrial electron transport chain, the membrane-associated NAD(P)H oxidase complex, or other sources. NO is produced by two NO synthase isoforms constitutively expressed by muscle fibers. ROS and NO derivatives are produced continually and are detectable in both the cytosolic and extracellular compartments. Production increases during strenuous exercise. Both ROS and NO modulate contractile function. Under basal conditions, low levels of ROS enhance force production. Excessive ROS accumulation inhibits force, for example, during fatiguing exercise. NO inhibits skeletal muscle contraction, an effect that is partially mediated by cyclic GMP as a second messenger. With aging, redox modulation of muscle contraction may be altered by changes in the rates of ROS and NO production, the levels of endogenous antioxidants that buffer ROS and NO, and the sensitivities of regulatory proteins to ROS and NO action. The impact of aging on contractile regulation depends on the relative magnitude of these changes and their net effects on ROS and NO activities at the cellular level.
This article is cited by:
J. W. E. Rush, H. J. Green, D. A. MacLean and L. M. Code. (2005) Oxidative stress and nitric oxide synthase in skeletal muscles of rats with post-infarction, compensated chronic heart failure. Acta Physiologica Scandinavica 185:3, 211–218
Abstract Abstract and References Full Text Article Full Article PDF
M. Wittwer, R. Billeter, H. Hoppeler and M. Flück. (2004) Regulatory gene expression in skeletal muscle of highly endurance-trained humans. Acta Physiologica Scandinavica 180:2, 217–227
Abstract Abstract and References Full Text Article Full Article PDF
A. R. Giniatullin and R. A. Giniatullin. (2003) Dual Action of Hydrogen Peroxide on Synaptic Transmission at the Frog Neuromuscular Junction. The Journal of Physiology 552:1, 283–293
Abstract Abstract and References Full Text Article Full Article PDF
Joseph Bruton, Pasi Tavi, Jan Aydin, Håkan Westerblad and Jan Lännergren. (2003) Mitochondrial and myoplasmic [Ca2+] in single fibres from mouse limb muscles during repeated tetanic contractions. The Journal of Physiology 551:1, 179–190
Abstract Abstract and References Full Text Article Full Article PDF

[dsade]

Interesting study...I might try some experiments taking NOxidant an hour BEFORE workout, with my calcium and Creatine...to see effects on contractile force. Looks like it could simultaneously prolong endurance.