Alpha-Yohimbine capsules

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  1. Quote Originally Posted by dsade View Post
    Waiting on the final OK from them, but so far both products look like a go.

    DSADE based on the article above do you think there is any possible negative intereactions between antidepressants (for exaplem fluoxetine) and alpha-yohimbe? The excerpt seems to speculate that it would have a potentiation of antidepressant effect but do you think there could be any possible negative effects from the potentiation of the monoamines effects?

    Mr.50


  2. Quote Originally Posted by Mr.50 View Post
    DSADE based on the article above do you think there is any possible negative intereactions between antidepressants (for exaplem fluoxetine) and alpha-yohimbe? The excerpt seems to speculate that it would have a potentiation of antidepressant effect but do you think there could be any possible negative effects from the potentiation of the monoamines effects?

    Mr.50
    Depression usually stems from imbalances AND shortages (lack of tone, too much reuptake too soon, too much MAO activity).

    As someone with dopaminergic depression, I was never happier - especially stacked with Wellbutrin.
    Evolutionary Muse - Inspire to Evolve
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    •   
       


  3. Quote Originally Posted by dsade View Post
    Depression usually stems from imbalances AND shortages (lack of tone, too much reuptake too soon, too much MAO activity).

    As someone with dopaminergic depression, I was never happier - especially stacked with Wellbutrin.


    Oh boy! This sounds good. What is the approximate timeline we are looking at here?

    Mr.50

  4. Quote Originally Posted by Mr.50 View Post
    Oh boy! This sounds good. What is the approximate timeline we are looking at here?

    Mr.50
    Probably 8 weeks.
    Evolutionary Muse - Inspire to Evolve
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  5. Quote Originally Posted by dsade View Post
    Probably 8 weeks.

    (im)-patiently waiting......

    Mr.50
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  6. Quote Originally Posted by dsade View Post
    Depression usually stems from imbalances AND shortages (lack of tone, too much reuptake too soon, too much MAO activity).

    As someone with dopaminergic depression, I was never happier - especially stacked with Wellbutrin.
    This could be a godsent for me then. I suffer from pretty severe depression/anxiety and have never been able to find a med w/ a good benefits\sides ratio for me.

    Oh ya, my libido usually sucks too. Im in Dsade, just wish I could try this somehow before the 8 weeks needed to stock it.


  7. Definitely interested in this product.

  8. Quote Originally Posted by dsade View Post
    Alpha-yohimbine is superior to regular yohimbine, both with binding affinities to the a2 receptor subtypes and central dopaminergic action/tone.

    It accounts for a MASSIVE enhancement of motivation and focus, with ZERO anxiety, no vascular constriction/bp or heart rate increases, annihilates appetite, and improves adipostat controls (central signal to the body on how much caloric expenditure to allow).

    For those that never got to try My and Par Deus' product, HEAT Stack by Avant Labs, you missed out.
    H.E.A.T. is good stuff. I'm taking it now (with a little Phenogen) - believe it or not, I still have an unopened bottle in the fridge, too.

    And count me in on the alpha-Y
  9. Thumbs up


    Nice work, Matt.

  10. I'd buy some of this,and knowing your history,a bottle of Clear Edge Renewed, wihout even knowing what's in it.

    feck yeah.

  11. Yo quiero este.

  12. Quote Originally Posted by dsade View Post
    Alpha-yohimbine is superior to regular yohimbine, both with binding affinities to the a2 receptor subtypes and central dopaminergic action/tone.

    It accounts for a MASSIVE enhancement of motivation and focus, with ZERO anxiety, no vascular constriction/bp or heart rate increases, annihilates appetite, and improves adipostat controls (central signal to the body on how much caloric expenditure to allow).

    For those that never got to try My and Par Deus' product, HEAT Stack by Avant Labs, you missed out.
    You serious about no BP, HR, vascular, and anxiety issues? I bought a bunch of those Y-hcl nutracaps on the impression it was not such a powerfull stimulant at all, but can't use them at all because they MASSIVELY effect my BP/HR and give me some anxiety. I'll be if I take them.

    I looked on Pubmed real quick and couldn't find any good articals about Alpha-Y except something in french with no abstract...

    Do you have anything to back up the "no negative sides" aspect of the Alpha-Y. It sounds very interesting, especially the mood/nuerotransmitter aspects, but I am warry of taking anything that could spike my BP/HR like the Y-hcl does.

  13. Quote Originally Posted by saludable24 View Post
    You serious about no BP, HR, vascular, and anxiety issues? I bought a bunch of those Y-hcl nutracaps on the impression it was not such a powerfull stimulant at all, but can't use them at all because they MASSIVELY effect my BP/HR and give me some anxiety. I'll be if I take them.

    I looked on Pubmed real quick and couldn't find any good articals about Alpha-Y except something in french with no abstract...

    Do you have anything to back up the "no negative sides" aspect of the Alpha-Y. It sounds very interesting, especially the mood/nuerotransmitter aspects, but I am warry of taking anything that could spike my BP/HR like the Y-hcl does.
    I'll start pulling and reposting the research, but also run a search for the feedback on HEAT Stack wrt Yohimbine sensitive users.
    Evolutionary Muse - Inspire to Evolve
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  14. Is eta 8 weeks for the Heatr stack? or just the alpha-Y caps? Either way it's gonna be a long wait.

  15. Quote Originally Posted by Ev52 View Post
    Is eta 8 weeks for the Heatr stack? or just the alpha-Y caps? Either way it's gonna be a long wait.
    Hopefully both.
    Evolutionary Muse - Inspire to Evolve
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  16. : Life Sci. 1994;54(10):PL179-84.Links
    The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration.
    La Marca S, Dunn RW.

    Anaquest, Inc., Murray Hill, NJ 07974.

    The alpha 2 agonist clonidine has been shown to be anxiolytic in a number of preclinical anxiety models. Interestingly, intravenous infusion of the alpha 2 antagonists idazoxan at 10 mg/kg and rauwolscine at 2.24 mg/kg significantly disinhibited lick-shock conflict responding in rats similar to the alpha 2 agonist clonidine (0.022 mg/kg) and the benzodiazepine diazepam (0.5 mg/kg). However, the alpha 2 antagonists yohimbine and piperoxan, the alpha 2 agonists medetomidine, guanfacine, and guanabenz, the non-specific alpha antagonist phentolamine, and the alpha 1 antagonist prazosin did not disinhibit conflict responding in the Vogel lick-shock paradigm. In fact, yohimbine has been shown to be anxiogenic in both animals and man. This may be due to yohimbine's lack of specificity and its ability to inhibit GABAergic release. In addition, all of these agents, except idazoxan, did not increase water consumption in water deprived rats. Idazoxan (10 mg/kg) significantly decreased water consumption by 45%. Therefore, idazoxan increased conflict responding for water reward at a dose (10 mg/kg) which also decreased water consumption in a non-conflict paradigm. These data suggest that agents with selective antagonism at the alpha 2 receptor site may be anxiolytic while agents with less specificity at this site such as yohimbine, piperoxan, and phentolamine are not anxiolytic.
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  17. Lightbulb


    Yes, I saw this study when I searched:

    Quote Originally Posted by dsade View Post
    : Life Sci. 1994;54(10):PL179-84.Links
    The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration.
    La Marca S, Dunn RW.

    Anaquest, Inc., Murray Hill, NJ 07974.

    The alpha 2 agonist clonidine has been shown to be anxiolytic in a number of preclinical anxiety models. Interestingly, intravenous infusion of the alpha 2 antagonists idazoxan at 10 mg/kg and rauwolscine at 2.24 mg/kg significantly disinhibited lick-shock conflict responding in rats similar to the alpha 2 agonist clonidine (0.022 mg/kg) and the benzodiazepine diazepam (0.5 mg/kg). However, the alpha 2 antagonists yohimbine and piperoxan, the alpha 2 agonists medetomidine, guanfacine, and guanabenz, the non-specific alpha antagonist phentolamine, and the alpha 1 antagonist prazosin did not disinhibit conflict responding in the Vogel lick-shock paradigm. In fact, yohimbine has been shown to be anxiogenic in both animals and man. This may be due to yohimbine's lack of specificity and its ability to inhibit GABAergic release. In addition, all of these agents, except idazoxan, did not increase water consumption in water deprived rats. Idazoxan (10 mg/kg) significantly decreased water consumption by 45%. Therefore, idazoxan increased conflict responding for water reward at a dose (10 mg/kg) which also decreased water consumption in a non-conflict paradigm. These data suggest that agents with selective antagonism at the alpha 2 receptor site may be anxiolytic while agents with less specificity at this site such as yohimbine, piperoxan, and phentolamine are not anxiolytic.
    But it didn't make sense until I read this post:

    Rauwolfia Serpentina Concentrate in Venom Hyperdrive 3.0+

    Quote Originally Posted by dsade View Post
    Rauwolfia contains Rauwolscine, AKA Alpha-yohimbine, a fantastic compound that I brought to market in HEAT Stack through Avant Labs.

    It has entirely different binding affinities to the A2 receptor subtypes than Yohimbine, including much more dopamine enhancement centrally and in crucial parts of the brain having to do with focus and motivation. It is also anxiolytic, which is a godsend to those people that freak out from taking regular Yohimbine (anxiety CAUSING).

    Yes, rauwolfia does contain reserpine, but it is easy to purge from a correctly done extract.
    Makes a lot more sense now.

  18. Quote Originally Posted by saludable24 View Post
    Yes, I saw this study when I searched:



    But it didn't make sense until I read this post:

    Rauwolfia Serpentina Concentrate in Venom Hyperdrive 3.0+



    Makes a lot more sense now.
    also of note in the study though I have purposely avoided mentioning due to already receiving word that a competitor is copying the STRANgE shots, is the effects of Yhcl on GABA.
    The alpha yohimbine, taken with the strange shots, will give a most intense, pleasurable experience - unlike Yhcl.


    hough I have


  19. Quote Originally Posted by dsade View Post
    I'll start pulling and reposting the research, but also run a search for the feedback on HEAT Stack wrt Yohimbine sensitive users.
    I had a long round w/ Y-hcl about 10 years ago (I'm probably the only one who remembers Nu-Life's GOoB sale), and I know exactly the kind of pangs, anxiety, etc, saludable talking about.

    Even taking HEAT @ the maximum recommended dosage (3x3) I have never had anything even remotely like a 'yohimbe-like' reaction. This after - what, 4 bottles? No experience w/ alpha-Yo as a stand-alone, but I have good confidence.

  20. Gonna be getting this when its out.

  21. Cant wait for HEATR stack.Be cool to pick up a few bottles of straight Alpha-Y too.Dsade, have u used HEAT and DCP together?Thats def gonna be my first stack

  22. Quote Originally Posted by phantom View Post
    Cant wait for HEATR stack.Be cool to pick up a few bottles of straight Alpha-Y too.Dsade, have u used HEAT and DCP together?Thats def gonna be my first stack
    HEAT and DCP is amazing - great synergy, and you can STILL add in a Yohimbine-free stim.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  23. Sweet-can't wait! Everything still going smooth with Heatr and Alpha-y caps?

  24. Quote Originally Posted by Trauma1 View Post
    I'm not surprised it worked well for your daughter. This type of formula is perfect for that type of condition.

    Sounds good to me, matt. The piperine addition is definitely a great idea. I swear the H.E.A.T. stack is one of the best products i've used to date. Clean and stim free energy/focus. Not to mention, it was one hell of a stack with dcp.
    X-F*CKING-2!

    LOVE ME SOME HEAT!

    Dsade - you know I'm in brah. I love Heat and Clear Shot. Really want to try Strange with Heat.

    Put me down for a few bottles of alpha-Y.

  25. Count me in as well!

  26. Skibidee-badooba

    Order PLACED!
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  27. Quote Originally Posted by dsade View Post
    Skibidee-badooba

    Order PLACED!
    Excellent.

  28. I was able, after 2 years of trying, to use my leverage to have a special extraction done.

    We should be able to get these high potency (probably 9mg each) in bottles of 100 caps for about $12-$14.

    I also picked up PLENTY to make sure the STRANGE shots are perfecto!

    No word yet on whether a new HEATR will be coming.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  29. damn, 2 caps of that ought to rock

  30. Quote Originally Posted by EasyEJL View Post
    damn, 2 caps of that ought to rock
    I'm also putting this into the STRANGE Boost. A capped version of the key ingredients that you can drop into your pocket for when the STRANGE Buzz starts to fade, if you so wish.

    A little BUMP.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
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