Vit. E Lowers Testosterone?

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    Vit. E Lowers Testosterone?


    Anyone know why in this study alpha-toc was shown to reduce testosterone levels? I thought the premise behind Toco-8 was that tocopherols and tocotrienols raise testosterone?

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    Quote Originally Posted by coolbreeze View Post
    Anyone know why in this study alpha-toc was shown to reduce testosterone levels? I thought the premise behind Toco-8 was that tocopherols and tocotrienols raise testosterone?

    Wiley InterScience :: Session Cookies
    Can you post the study again?

    -Pp
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    Quote Originally Posted by coolbreeze View Post
    Anyone know why in this study alpha-toc was shown to reduce testosterone levels? I thought the premise behind Toco-8 was that tocopherols and tocotrienols raise testosterone?

    Wiley InterScience :: Session Cookies
    yeah, I cant open the study also
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    maybe this is what he saw

    Alpha-tocopherol affects androgen metabolism in male rat.
    Barella L, Rota C, Stöcklin E, Rimbach G.

    DSM Nutritional Products, Research and Development, Human Nutrition and Health, CH-4303 Kaiseraugst, Switzerland. luca.barella@dsm.com

    The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study has provided the first evidence implicating vitamin E in hormone synthesis. The effect of vitamin E on stereoidogenesis in testes and adrenal glands was assessed in growing rats using Affymetrix gene-chip technology. Dietary supplementation of rats with vitamin E (60 mg/kg feed) for a period of 429 days caused a significant repression of genes encoding for proteins centrally involved in the uptake (low-density lipoprotein receptor) and de novo synthesis (for example, 7-dehydrocholesterol reductase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, isopentenyl-diphosphate delta-isomerase, and farnesyl pyrophosphate synthetase) of cholesterol, the precursor of all steroid hormones. The present investigation indicates that dietary vitamin E may induce changes in stereoidogenesis by affecting cholesterol homeostasis.
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    Quote Originally Posted by crazyfool405 View Post
    maybe this is what he saw

    Alpha-tocopherol affects androgen metabolism in male rat.
    Barella L, Rota C, Stöcklin E, Rimbach G.

    DSM Nutritional Products, Research and Development, Human Nutrition and Health, CH-4303 Kaiseraugst, Switzerland. luca.barella@dsm.com

    The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study has provided the first evidence implicating vitamin E in hormone synthesis. The effect of vitamin E on stereoidogenesis in testes and adrenal glands was assessed in growing rats using Affymetrix gene-chip technology. Dietary supplementation of rats with vitamin E (60 mg/kg feed) for a period of 429 days caused a significant repression of genes encoding for proteins centrally involved in the uptake (low-density lipoprotein receptor) and de novo synthesis (for example, 7-dehydrocholesterol reductase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, isopentenyl-diphosphate delta-isomerase, and farnesyl pyrophosphate synthetase) of cholesterol, the precursor of all steroid hormones. The present investigation indicates that dietary vitamin E may induce changes in stereoidogenesis by affecting cholesterol homeostasis.
    strange , there's a lot of studies that say the opposite
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    Quote Originally Posted by nunes View Post
    strange , there's a lot of studies that say the opposite

    its mainly a protective supplement to the leydig cells, which is what i gather,

    the only time INCREASES were observed was when in DEFICENT rats. not NORMAL rats wo take enough Vit E anyway. and the rat studies dont always translate exactly to human studies
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    These are normal human males that had a testosterone boost from vitamin e and increased sensitivity to hCG.

    Effect of Vitamin E on Function of Pituitary-Gonadal Axis in Male Rats and Human Subject
    Fumio et al
    Endocrinology, Japan. 29(3) 287-292 (1982)


    -Pp
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    Sorry about that link expiring. Now of course its hard to find, however the tocopherols are different from tocotrienols anyhow right? And it seems the guys at PP have labs to show Toco 8 works as intended right?
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    Quote Originally Posted by Primordial Perf View Post
    Can you post the study again?

    -Pp
    Just remove the garbage from the end of the URL and it works:

    http://www3.interscience.wiley.com/j...10372/abstract
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    i dont know how signifigant it is, its used in older men

    they testicular function is declined as it is

    Vit E seems to be protective to the leydig cells,
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    Quote Originally Posted by crazyfool405 View Post
    Vit E seems to be protective to the leydig cells,
    for all that I read , I agree with this
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    Quote Originally Posted by coolbreeze View Post
    Sorry about that link expiring. Now of course its hard to find, however the tocopherols are different from tocotrienols anyhow right? And it seems the guys at PP have labs to show Toco 8 works as intended right?
    Yes, feedback has shown an overall increase in T levels from Toco-8. This is the first negative correlation I’ve seen with androgens and Vitamin E. Ill get the full text and check it out…

    -Pp
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    Quote Originally Posted by Primordial Perf View Post
    Yes, feedback has shown an overall increase in T levels from Toco-8. This is the first negative correlation I’ve seen with androgens and Vitamin E. Ill get the full text and check it out…

    -Pp
    Query whether they used soybean oil for the vitamin E in that study.
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    I just have to say that I have gone through about 2/3s a tub of Toco-8 (old version) at 2x/day and same with EndoAMP and I feel like I am one of the best T-boosters. My drive is up, mood is up, sexy dreams are more frequent, libido and function seem to be up as well. All signs my body is producing T more efficiently. I am impressed.

    The only other thing I am taking other than that is ALCAR at about 3.5g/day. Though I've used it before, I feel a difference above and beyond what I have had with ALCAR in the past as far as the above factors go.

    I still have another tub of each left and look forward to the next month on them. If my budget allows I may get some more and just keep going another 2 or more months since they are working so well for me.
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    Quote Originally Posted by saludable24 View Post
    I just have to say that I have gone through about 2/3s a tub of Toco-8 (old version) at 2x/day and same with EndoAMP and I feel like I am one of the best T-boosters. My drive is up, mood is up, sexy dreams are more frequent, libido and function seem to be up as well. All signs my body is producing T more efficiently. I am impressed.

    The only other thing I am taking other than that is ALCAR at about 3.5g/day. Though I've used it before, I feel a difference above and beyond what I have had with ALCAR in the past as far as the above factors go.

    I still have another tub of each left and look forward to the next month on them. If my budget allows I may get some more and just keep going another 2 or more months since they are working so well for me.
    Agree. I ran EndoAmp and Toco-8 exclusively for awhile since the older version of Sustain Alpha gave me some skin issues. They worked great on their own.
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    Quote Originally Posted by EIC View Post
    Agree. I ran EndoAmp and Toco-8 exclusively for awhile since the older version of Sustain Alpha gave me some skin issues. They worked great on their own.
    These are 2 of the best supplements on the vitamin market today, not just for weight lifting males, but for everyone over 35. This is cutting edge technology and intelligent vitamin supplementation at its best.
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    Just ordered 2 more of Toco and Endo each with the 20% holiday cupon from the PP site. You guys are awsome, PP.
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