This doesn't mean that Alpha-T2 won't cause weight loss. The use of methyl-synephrine is likely to cause some thermogenesis and or appetite reduction.
Personally, I would use 3,5-T2 only if I couldn't get real T3. T3's effects are so well known and suppression of TSH is not a serious concern.
i missed out i guess,,,so lets go at it again please...
Life Sci. 1998;62(26):2369-77.
Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats.
Moreno M, Lombardi A, Lombardi P, Goglia F, Lanni A.
Dipartimento di Chimica, Facoltà di Scienze, Università degli Studi di Salerno, Italy.
We have investigated the biological effects of physiological doses of 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) (at doses from 2.5 to 10 microg/100 g BW) on serum TSH and GH levels in rats made hypothyroid by propylthiouracil and iopanoic acid administration. In such animals deiodinase activities were inhibited and thyroid hormones serum levels strongly reduced. The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2.5 microg/100 g BW).The serum TSH level was much greater in hypothyroid rats than in euthyroid ones. T3 administration suppressed TSH by 88% compared to control (i.e, the level in hypothyroid rats); it thus reached a value not significantly different from that seen in the euthyroid rats. 3,5-T2 produced a similar effect, suppressing the TSH level by about 75% compared to control; it thus reached values not significantly different from those of the euthyroid and T3-treated rats. By contrast, 3,3'-T2 had no effect on TSH, whatever the dose. The serum GH level was much lower in hypothyroid rats than in euthyroid ones. T3 administration increased the GH level by about 5-fold, restoring it to the value seen in euthyroid rats. 3,5-T2-treated hypothyroid rats, at all the doses used (from 2.5 to 10 microg/100 g BW), showed increased serum GH levels: at a dose of 10 microg/100 g BW the level reached a value about 5-fold higher than that in hypothyroid rats. This value was not significantly different from those of euthyroid and T3-treated rats. 3,3'-T2 did not affect GH levels whatever the dose. Thus, 3,5-T2 (but not 3,3'-T2) seems to mimic the effects of T3 on serum TSH and GH levels in rats.
PMID: 9651103 [PubMed - indexed for MEDLINE]
okay so you have a compound thats supposed to work on metabolic rate but you are saying that wont lower TSH?
thats like saying i have a compound taht will work on androgenic receptor and wont shut you down, lowering LH/FSH,,,,sounds too good.
i would use 3,5 version and compensate lowered TSH and it will rise to normal, so same as coming off T3,,,taper off, and careful with diet during thryoid 'pct' or take stimulants then or something,,,,i see using 3,5's benefit is that it is OTC, if anybody is selling them still
now i would like to see a study or two showing 3,3' diiodo doing samething to RMR like 3,5 or 3,5,3 because i was unable to find one. Im not saying other folks with good results arent bs'ng i just want to see how it differs other than what ive seen is that 3,3 is non thyromimetic.
There is ONE study that I found from several years back that showed 3,3-T2 to increase caloric expenditure, but no study since then supports this claim. Moreno is one of the primary researchers on these compounds and in a recent review of iodothyronines, they state that 3,3-T2 had no effect on metabolic rate, whereas 3,5-T2 does.
If 3,3-T2 DID have metabolic effects, then it and not 3,5-T2 would be the compound one would expect researchers to investigate, since it doesn't affect TSH levels. The lack of interest in this compound points to the fact that it doesn't increase RMR.
well said micro2k,
like i said it would be a gold mine or something, for diet and medical aspect.
ying/yang balance....cant go around that homeostasis.
this thread is beginning to remind me of the recent arginine thread, where some of the studies suggested it is 'worthless'.
but it is the studies that are 'worthless' when real world experiences prove them wrong. take a look at the review section and see what the real world looks like. ALPHA T-2 is kicking asss in the reviews-and don't try to blow it off as methyl-synephrine as the only cause for such positive results.
i recently finished a bottle of ALPHA T-2 and plan on using another bottle real soon. very good supplement!!!
WOW!! I was just looking on NP. Thinking of ordering Alpha T-2 or TT-33. Saw the stack AT-2/Lean Xtreme. Thinking of doing this with OEP, Recompadrol, DCP, Eviscerate, Chromium Picolinate,...Carbs between 100-150 gms/day. After reading some forums it sound like TT-33 is getting it's ass kicked be Alpha T-2. Any suggestions on "The Stack" or my upcoming "Stack" would be greatly appreciated! Thanks.
And there is no reason why methyl-synephrine can't be the effective component of this product. Weight loss occurs with ephedrine, yohimbine, clenbuterol, albuterol, etc. and none of these contain any thyromimetic component.
Just because no study since then supports the claim does not make the claim false. In that study they were basing metabolic rate off of TSH shutdown. Metabolic rate has more factors than just TSH. Just because researchers did not further investigate 3,3-T2 does not mean that it did not have metabolic effects.
For the past 3-4 years numerous users have taken 3,3-T2 alone, with no other compounds, and have felt significant effects at doses around 150mcg 2-3x per day.
But beyond this one compound, Alpha-T2 also contains 2 other extremely effective compounds, Methyl-synephrine and Rauwolscine HCl which should not be overlooked. No single ingredient in Alpha-T2 is more or less important than another.
One of the studies referenced in the product write up "Metabolic Effects of Thyroid Hormone Derivatives" the authors state that 3,3-T2 did not affect RMR.Metabolic rate has more factors than just TSH. Just because researchers did not further investigate 3,3-T2 does not mean that it did not have metabolic effects.
What other products contains only 3,3-T2? The ones I am familiar with are a combination of 3,3 and 3,5, or are modified thyromimetics, like diprop and triprop.For the past 3-4 years numerous users have taken 3,3-T2 alone, with no other compounds, and have felt significant effects at doses around 150mcg 2-3x per day.
And, IMO, this is the product's saving grace. I believe it would have been better if 3,3 was substituted with 3,5.But beyond this one compound, Alpha-T2 also contains 2 other extremely effective compounds, Methyl-synephrine and Rauwolscine HCl which should not be overlooked. No single ingredient in Alpha-T2 is more or less important than another.
I am not going to have a study argument on here. Everyone knows that they never end up with any said conclusion. Everyone has their opinions and has the right to stick to them.
A few years back you could buy bulk 3,3-T2 capsules from a few bulk supplement companies. Users get effects from 3,3-T2 alone, regardless of what 1-2 studies you have read do or do not say.
We chose the 3,3-T2 over 3,5-T2 because we did not want a suppressive supplement. IMO the fact that 3,5-T2 mimics T3 in terms of TSH is awful.
I have been a member of plenty of boards, such as AM back in the day, where there were T3 users running logs posting results all the time. I cannot tell you how many times users would run T3 and lose 15lbs and 4 weeks after stopping their cycle gain 20lbs due to TSH shutdown.
We did not want a product that would let users lose some weight while taking it but then gain it back when they stopped. That is not our idea of a useful supplement.
The other two ingredients are much much more than a "saving grace". They all compliment each other towards one common goal...losing fat. This product has already proven to help users reach their fat burning goals.
i highly recommend ALPHA T-2 to anyone on a cut/recomp or lean bulk.
BIOTEST!!!!!!! T-2 Pro. Still sold up here in Canada.
You are correct sir! My bad!
Now 3,3 is suppose to cause little to no suppression correct? Therefore does the stack with Lean Xtreme prevent any suppression and all you reap are the fat burning benefits?
If that is the case one should not put on any weight after the cut due to suppression correct?
I'll be stacking Alpha-T2 with Dermacrine-LV for some recomping. I don't care to lose weight. My goal is to shed fat without losing muscle. I'm a bit sensitive to stims so I was worried about throwing OEP in the mix as well.