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August 30, 2006
NSAIDS delay prostate enlargement
An advance online report published on August 11, 2006 in the American Journal of Epidemiology found an association between daily nonsteroidal anti-inflammatory drug (NSAID) use and delayed onset of benign prostatic hyperplasia, a condition characterized by enlargement of the prostate gland which causes frequent urination and other symptoms.
Researchers at the Mayo Clinic led by epidemiologist Jenny St. Sauver, PhD followed 2,447 Caucasian men from 1990 to 2002. Participants completed questionnaires upon enrollment and every two years thereafter which provided information on the use of NSAIDs such as aspirin or ibuprofen. A subset of men participated in a medical examination that included assessment of prostate specific antigen (PSA) levels and ultrasound imaging of the prostate gland.
One-third of the men were taking NSAIDs daily at the beginning of the study. The research team found that men who used NSAIDs had a 27 percent lower age-adjusted risk of developing moderate to severe urinary symptoms compared to nonusers. Additionally, NSAID users had nearly half the risk of developing low maximum flow rate, prostate enlargement and elevated PSA than nonusers. Neither dosage nor type of NSAID used appeared to affect the association.
"The typical scenario with benign prostatic hyperplasia is that men start getting up three to five times a night to urinate, and their wives ultimately force them to go see a urologist," study coauthor and Mayo Clinic investigator Michael Lieber, MD observed. "Men also might come in if they have problems with daytime urinary frequency. All this adversely affects men's quality of life."
"Our study suggests that one potential unintended consequence of so many people in our society taking NSAIDs could be an improvement in urinary health for men," he concluded. "So, if a person's primary care doctor recommends NSAIDs for some other reason, prostate health might be an additional benefit."
NSAIDS delay prostate enlargement
An advance online report published on August 11, 2006 in the American Journal of Epidemiology found an association between daily nonsteroidal anti-inflammatory drug (NSAID) use and delayed onset of benign prostatic hyperplasia, a condition characterized by enlargement of the prostate gland which causes frequent urination and other symptoms.
Researchers at the Mayo Clinic led by epidemiologist Jenny St. Sauver, PhD followed 2,447 Caucasian men from 1990 to 2002. Participants completed questionnaires upon enrollment and every two years thereafter which provided information on the use of NSAIDs such as aspirin or ibuprofen. A subset of men participated in a medical examination that included assessment of prostate specific antigen (PSA) levels and ultrasound imaging of the prostate gland.
One-third of the men were taking NSAIDs daily at the beginning of the study. The research team found that men who used NSAIDs had a 27 percent lower age-adjusted risk of developing moderate to severe urinary symptoms compared to nonusers. Additionally, NSAID users had nearly half the risk of developing low maximum flow rate, prostate enlargement and elevated PSA than nonusers. Neither dosage nor type of NSAID used appeared to affect the association.
"The typical scenario with benign prostatic hyperplasia is that men start getting up three to five times a night to urinate, and their wives ultimately force them to go see a urologist," study coauthor and Mayo Clinic investigator Michael Lieber, MD observed. "Men also might come in if they have problems with daytime urinary frequency. All this adversely affects men's quality of life."
"Our study suggests that one potential unintended consequence of so many people in our society taking NSAIDs could be an improvement in urinary health for men," he concluded. "So, if a person's primary care doctor recommends NSAIDs for some other reason, prostate health might be an additional benefit."
