Brand / Dose
What are "known resveratrol absorption enhancers"? I understand that doses are controversial, but how much are you guys taking?
After some research I believe one of the better resveratrol products available is this full spectrum
trans-resveratrol formula from Life Extension Foundation - "Optimized Resveratrol" 250mg trans-resveratrol. 60 caps is $34.
I have been taking the recommended one cap a day (250mg) for about 6 months.
This formula also contains "Whole Grape Extract" which is important as it has been reported that there is a synergistic effect and trans-resveratrol is more effective when taken concurrently with a whole grape extract formula (some formulas only contained the isolated resveratrol).
Also, make sure your resveratrol is
trans-resveratrol - a much more effective component.
From the Life Extension Foundation website:
Optimized Resveratrol
250 mg, 60 vegetarian capsules
Item Catalog Number: 00867
Findings from published scientific literature indicate that resveratrol may be the most effective plant extract for maintaining optimal health.103
Scientists have hypothesized that resveratrol may be a key component of the famous “French Paradox,” whereby the French traditionally were protected against heart disease despite a diet high in butter and animal fats. Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera as a response to attack by molds. Because of the wide-spread use of pesticides in modern wine-making, including the practice of copper sulphation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest, and other factors. In fact, usually only one to three mg resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.
This whole grape extract contains a spectrum of polyphenols that are naturally contained in red wine such as proanthocyanidins, anthocyanins, flavonoids, etc.
Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol’s positive benefits including improved insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the toxic effects of a high-fat diet.
Resveratrol, in particular
trans-resveratrol and its glucoside, are widely reported to be beneficial to health, having been shown to possess antioxidative, anticarcinogenic, and antitumor properties. Major dietary sources include grapes, wine, peanuts, and soy; however, they can also be introduced into the diet through Itadori tea, which has long been used in Japan and China as a traditional herbal remedy for heart disease and strokes. Analysis of grapes, peanuts, and Itadori tea shows that they contain mainly
trans-resveratrol glucoside. In contrast, red wines are primarily a source of the aglycones cis- and
trans-resveratrol.
Life Extension has evaluated the published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension’s analysis yield a wide range of potentially effective doses: from 20 to 250 mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span. Life Extension offers Optimized Resveratrol, a supplement that contains 250 mg of standardized trans-resveratrol for those who want optimal potencies.
References
Supplement Facts
Serving Size 1 vegetarian capsule
Servings Per Container 60
Amount Per Serving
Trans-resveratrol [from red grape & vine (Vitis vinifera) and Polygonum cuspidatum (root) extract]
250 mg
Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Grape Vine (Vitis vinifera), Wild Blueberry (Vaccinium angustifolium), and Polygonum cuspidatum extract blend [supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)]
85 mg
Quercetin (as Quercetin dihydrate)
60 mg
Other ingredients: silica, magnesium stearate, vegetable cellulose (capsule).
Contains corn. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule daily with or without food, or as recommended by a healthcare practitioner.
