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Sermorelin..better than HGH?

Dr. John said:
Once again, HeadDoc launches toward the future.

I have been thinking about Sermorelin for some time now. While speaking at a medical conference in Denver in June, sponsored by College Pharmacy, I heard two lectures on the subject which, frankly, stopped me dead in my tracks (one must always maintain an open mind in medicine, and remain a true man or woman of science). Dr. Walker's presentation dropped my jaw.

Except for a couple of my patients who do not possess a pituitary gland, I believe I will soon be switching my Adult Onset Growth Hormone Deficiency patients over to this new treatment strategy. I just need a bit more time to think about my pathways.

In short, Sermorelin is to the pituitary as HCG is to the testes.
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Unlike HGH, Sermorelin affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, has a better safety profile, and its use for adult hormone deficiency is not restricted (as is HGH).*
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*Dr. Richard F. Walker, Invalid Link Removed.
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While there is a wealth of information showing that long-term administration of
rhGH reduces intrinsic disease and extends life in adults suffering pathogenic GHD,
consensus on whether extrapolation of those data to the aging condition is justified
has not been reached (Perls et al 2005). Most of the major concerns derive from the
fact that rhGH is mitogenic and may awaken latent cancers, that improper dose
selection may promote metabolic disorders such as diabetes, and perhaps that
pharmacological presentation may exacerbate decline of endocrine function by
distorting essential hormonal interactions.
-------------------------------------
Effects are regulated by negative feedback involving the
inhibitory neurohormone, somatostatin, so that unlike
administration of exogenous rhGH, overdoses of
endogenous hGH are difficult if not impossible to
achieve,
---------------------------------------
Unlike
rhGH which has legal restrictions on its clinical use, the
off-label prescribing of sermorelin is not prohibited by
federal law.
-----------------------------------------------
In support of this effort, the Society for Applied Research
in Aging will be providing sermorelin free of cost on a
competitive basis to practitioners willing to study its effects
under protocol conditions and to report the outcomes in a
peer-reviewed journal such as Clinical Interventions in
Aging
 
Have a freind who is on this and likes it very much so far. I was going to bring it up when he updates me on it's effectiveness.
 
with all the attention these days to abuse of steroids and even Stallone's arrest in Australia for more vials of HGH than the rest of us use in several months, you'd have to think that any negative outcome from HGH in adults would be on the front page of every newspaper. The occurance of cancers or diabetes would be good stories. And yet, not a story!
 
Dr. John said:
A direct, and obvious, concern is that the same forces which inhibit GH production, in the face of GHRH, still will be at work.
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We talking estrogen, possible insulin resistance here?

On a second note, this stuff seems very very promising.

What are the costs? Insurance covers anything?

My IGF-1 level 130 (126 - 350)
 
plymouth city said:
We talking estrogen, possible insulin resistance here?

On a second note, this stuff seems very very promising.

What are the costs? Insurance covers anything?

My IGF-1 level 130 (126 - 350)
Click to expand...
Invalid Link Removed
In support of this effort, the Society for Applied Research
in Aging will be providing sermorelin free of cost on a
competitive basis to practitioners willing to study its effects
under protocol conditions and to report the outcomes in a
peer-reviewed journal such as Clinical Interventions in
Aging
 
JanSz said:
Invalid Link Removed
In support of this effort, the Society for Applied Research
in Aging will be providing sermorelin free of cost on a
competitive basis to practitioners willing to study its effects
under protocol conditions and to report the outcomes in a
peer-reviewed journal such as Clinical Interventions in
Aging
Click to expand...

Dr John, are you involved in this in any way?

No way shape or form would I get involved in this unless I was under Dr Johns care.....But if he gave the go I would be in.
 
I got in contact with the sermorelin people and they are sending me a bunch of information - I will post it up when it arrives. :drunk:
 
I emailed my friend..we'll see if he's game to post or email his impressions. He and his wife have a lot going on so we'll see.
 
Got a reply from my friends and they say they are not using it yet..due to the high price tag.

They mentioned a "Dr Shallenberger" is their anti-aging Doc and he swears by it.
 
bioman said:
Got a reply from my friends and they say they are not using it yet..due to the high price tag.

They mentioned a "Dr Shallenberger" is their anti-aging Doc and he swears by it.
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Yep, it figures.

No point in running a "free" trial of it from the makers when one can't afford it long term
 
So how much is too much? What does it cost long term? I estimated it to be about 100 times more costly than hgh. Anybody?
 
My friends say;

"HGH sells for like $9-$11 an iU through the doc. Dr Shallenberger says to expect to pay quite a bit more for Sermorelin. So I can only imagine how expensive it would be. I would have to take 3iu and "P" 4iu a day. We just can't afford that."

Yeah, expensive habit.
 
bioman said:
My friends say;

"HGH sells for like $9-$11 an iU through the doc. Dr Shallenberger says to expect to pay quite a bit more for Sermorelin. So I can only imagine how expensive it would be. I would have to take 3iu and "P" 4iu a day. We just can't afford that."

Yeah, expensive habit.
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:wtf:

Yea, LOL. I can think of much better ways to spend 40 bucks a day.

To be honest, I can't justify spending the 10 bucks a day for HGH. Maybe one day........:whiner:
 
cost

according to the website it's 10-15% cheaper.

Question: Are the doctor's costs for hGH and Sermorelin comparable?

Dr. Richard Walker: Costs of Sermorelin per vial is about 10 – 15% less expensive than hGH. Furthermore, a vial of hGH usually last approximately 12 – 14 days. In contrast, based upon clinical information defining the effective dose for stimulation of the pituitary gland, one multidose vial will be sufficient to last for 15 days.

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Sermorelin according my A-A Doc

hi All,

I go to an Anti-Aging Clinic in H-town for general nutrition, TRT ( pellets - Love 'em! ) and HCG. On a recent follow-up, my Doc talked about Semorelin. He likes to try stuff out on himself before recommending any new therapy to his patients. According to his trial ( don't remember the exact amounts but it was the equivalent of what would be 1IU per day of HGH ), his bloodtests showed the Sermorelin to increase IGF-2 about 90% as well as HGH. Again, I don't have specific numbers, but he also indicated that it is less expensive than HGH ( but not by a significant amount - if I had to guess, I'd say maybe 20-25% less at most ).

srczm
 
sarcazmo said:
hi All,

I go to an Anti-Aging Clinic in H-town for general nutrition, TRT ( pellets - Love 'em! ) and HCG. On a recent follow-up, my Doc talked about Semorelin. He likes to try stuff out on himself before recommending any new therapy to his patients. According to his trial ( don't remember the exact amounts but it was the equivalent of what would be 1IU per day of HGH ), his bloodtests showed the Sermorelin to increase IGF-2 about 90% as well as HGH. Again, I don't have specific numbers, but he also indicated that it is less expensive than HGH ( but not by a significant amount - if I had to guess, I'd say maybe 20-25% less at most ).

srczm
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Awesome, thanks.

What is his price for HGH
 
sarcazmo said:
$300-ish/month for 1IU/day last I checked.

srczm
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Sermorelin is measured in milligrams, and the prescribed doses are in micrograms. The recommended doses are usually between 200 and 300 micrograms per day, and based on the individual's sex and BMI. A 3 milligram bottle would last 10 to 15 days. I just found a price of $90 per 3 MG vial. Of course a doctor has to prescribe it.
 
colkurtz_spf said:
Sermorelin is measured in milligrams, and the prescribed doses are in micrograms. The recommended doses are usually between 200 and 300 micrograms per day, and based on the individual's sex and BMI. A 3 milligram bottle would last 10 to 15 days. I just found a price of $90 per 3 MG vial. Of course a doctor has to prescribe it.
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Yep, Im a lightweight too, so about 180 bucks a month for me.

The goomba in me won't ever allow myself to fork that over. :rofl:
 
I got prescribed Sermonelin right after the big GH bust when the feds took all the generic Somatropin.
Before that my insurance was paying for my GH..
Did not cover Sermonelin, I weigh 165 and the cost was 200 a month. No way to partial dose or use less like with GH.

My doc switched to it and is no longer on it because he says he never felt much and it takes too long to work.
I have another doc buddy who is taking it and feels pleased.
He was paying out of pocket 800 month for GH so he is happy.

So I think the jury is still out. If they could get it under a hundred a month I'd be on it.
 
dougpacker said:
I got prescribed Sermonelin right after the big GH bust when the feds took all the generic Somatropin.
Before that my insurance was paying for my GH..
Did not cover Sermonelin, I weigh 165 and the cost was 200 a month. No way to partial dose or use less like with GH.

My doc switched to it and is no longer on it because he says he never felt much and it takes too long to work.
I have another doc buddy who is taking it and feels pleased.
He was paying out of pocket 800 month for GH so he is happy.

So I think the jury is still out. If they could get it under a hundred a month I'd be on it.
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I ran it for 8 weeks and had an IGF-1 of 130. I ran it for another 8 at double the recommended dose and the IGF-1 was127. I am now off for 6 + weeks and preparing for another lab. Sorry I did not get a post HGH level.
 
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