DIM
- 05-07-2017, 02:08 PM
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From Examine:
"It has potent effects on estrogen metabolism and is able to keep the body relatively balanced (by preventing either drastic increases or decreases in estrogen). In small amounts, it can both inhibit the aromatase enzyme (and prevent conversion of testosterone into estrogen) and it can act on more potent forms of estrogen and convert them into less potent forms; this conversion reduces the overall effects of estrogen in the body. However, taking too much DIM at once can actually induce the aromatase enzyme and act in the opposite manner and increase estrogen synthesis." - 05-07-2017, 07:01 PM
There is conflicting data on this one; as is true with many supplements in this category. Many sources classify if as an anti-androgen. So yes...in this case you would be correct in saying that it could possibly lower other hormones.
Given this, I think it is best to stay away from this one.. - 05-07-2017, 11:01 PM
- 05-07-2017, 11:50 PM
On TRT now and using a Sub Q protocol every 3.5 days, with DIM; Pregnenolone, and DHEA which is working out well so far. All numbers were normal but my test was 400 only and I didn't quite feel well enough at that number so I have upped my dose to 75mg every 3.5 days. I'll be getting bloods in another 4 weeks and go from there. Feeling better after 2 weeks, and I think this might be the right dose for me.
Edit: I'm a bit on my own here as my doctor trusts I'm in good hands with my wife who runs the lab at the hospital. He's right, but I'm pretty much doing everything. I communicate with my doc through the office's secure web portal. It's pretty tight. I like to give him updates as I'm the only one of his patients on this protocol. - 05-08-2017, 12:36 AM
DIM does not lower estrogen it just shifts the metabolism of 16 to 2 OHE.
The same thing can be achieved with iodine as it will shift the 16 OHE to e3. This is why iodine is highly protective in breast tissue in females
I often suggest DIM in mold cases ad it has a huge impact on immune system modulation as well as it alters gene expression as noted in clinically studies as it turn on Nrf2.
I also fine it helpful with viral loads as well
https://www.ncbi.nlm.nih.gov/pubmed/24466240I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider. - 05-08-2017, 08:58 AM
I wish we could sticky some facts on DIM because way too many guys are getting the impression that it lowers estrogen or acts like an AI. It metabolizes the bad to good- so it is good to take, but not to actually lower e2.
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- 05-08-2017, 09:23 PM
I have shifted to focusing on researching botanicals for lower estrogen as there are many out there that have anti aromatase properties that look promising to replacing AI's in the near future.
I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider. - 05-08-2017, 09:40 PM
- 05-09-2017, 09:16 AM
- 05-09-2017, 10:36 AM
- 05-09-2017, 10:41 AM
- 05-09-2017, 03:51 PM
If you are in opiates or pain killers it can impact cyp3d4 which will inhibit antii aromatases. I have cases due to being on Percocet and other meds need up to 1
Mgs a dayI am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider. - 05-09-2017, 03:59 PM
Long term AI I have experience increase memory issues and alters my moods. Being aspergers, any impact of neurological inflammtion or hormone shifts can significantly alter my chemistry. It has nothing to do with e2 levels because they had been stable and still AI causing cognitive issues. Since I stopped them memory has been sharp. I can not afford to slip up at any level. This is my own experience as many very well known HRT share same view. This is my own experiences, but has been supported by others
I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider. - 05-10-2017, 09:49 AM
- 05-10-2017, 09:56 AM
With out proper Stomach HCL you will not get the benefits from cruciferous veggies to cover to DIM. This is why IC3 is a waste on many level with people with chronic illness
Majority of population have low stomach acid from chronic stress. This is one of the factors to how stress promotes certain forms of cancer due to low HCL increasing intestinal dysbiosis altering the metabolism of proteins, carbs and fats to proinflammatory response.
Dim can increase e2 in presence of a viral load as I see this a lot clinicallyI am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider. - 05-10-2017, 09:59 AM