test and estrogen imbalance question...
- 04-07-2011, 10:38 AM
test and estrogen imbalance question...
I came across a decent article while doing some research the other day:
specifically my question is about these snippets from it:
"The most significant hormone imbalance in aging men is a decrease in free testosterone while estrogen levels remain the same or precipitously increase. Some men convert their testosterone to estrogen. In some men testosterone replacement therapy by itself does not work because the replacement testosterone may convert (aromatize) into even more estrogen. Estrogen is a necessary hormone for men, but too much causes a wide range of health problems such as heart attacks and stroke. High levels of estrogen have been implicated as a cause of benign prostatic hypertrophy and one mechanism by which nettle extract works is by blocking the binding of growth-stimulating estrogen to prostate cells. "
"High levels of estrogen in men also trick the brain into thinking that enough testosterone is being produced, thereby slowing down the natural production of testosterone. Based on the multiple deleterious effects of excess estrogen in men, aggressive actions should be taken to reduce estrogen to a safe range if a blood test reveals elevated levels.
Remember, excess estrogen (estradiol) blocks the production and effect of testosterone throughout the body, dampens sexuality, and increases the risk of prostate and cardiovascular diseases."
"If all of the above fail to increase free testosterone and lower excess estradiol, then the potent aromatase inhibiting drug Arimidex (anastrozole) in the very low dose of ½ (0.5 mg) twice a week is indicated. This should cause an immediate drop in estradiol levels and a rise in free testosterone."
My estradiol levels ARE high, however LH level is good, test level is abysmal at only 277. I'm just taking what I'm reading there, and wondering before I take the plunge and go right for TRT if it would be worth trying an AI such as arimidex first and see if that will help with getting my natural levels back up. The bloods would indicate to me at least that I should be able to produce test, but the high level of estrogen is telling my body it doesn't need to. Is there a better one out these days than arimidex, and at what dose would I try it at?
- 04-07-2011, 11:02 AM
I would like to know this also. Bump
- 04-07-2011, 11:22 AM
I would like to know WTF they are teaching at med school now. TRT is obviously at the forefront now, but finding a doctor that knows what to do with lab tests is a joke. "Hell! I can read the test too doctor. Now what???" I hope you have some luck figuring out your situation. Ok, that was a rant.....
04-07-2011, 11:30 AM
04-07-2011, 11:39 AM
04-07-2011, 11:44 AM
Well, the primary differences imo is that exemestane is easier on lipids, lowers IGF less and at "normal" dosing I think reduces estrogen to less of a percent than arimidex (meaning slightly higher estrogen levels with exemestane). For a person not on a cycle, arimidex dosing needs to be played with more to get optimal control of estrogen without wiping it out, exemestane seems easier to get there with.
Really an irreversible AI is what you want, you want that daily production of aromatse enzyme wiped out and gone as your body will create more as time goes by anyhow.
04-07-2011, 12:52 PM
awesome insight bro. Reps for you. I think I'm gonna it out for a bit and just see if it makes a difference or not. It really would make no sense to search out someone who will put me on TRT if the extra test is just going to end up being converted into more estrogen, so we'll see if this makes a difference.
I wish I had an AI on hand atm, but I've actually NEVER used an AI in my life, I've used plenty of SERMS in PCT, but have never used an AI. All I have on hand atm is a bottle of formestane.
04-07-2011, 12:58 PM
Thats not a bad choice, a lot of guys like using it. I like the way it feels but haven't bought any in a while
04-07-2011, 01:03 PM
Good dosage for estrogen control? Somewhere in the 50-100mg per day range?
04-07-2011, 01:21 PM
Yeah, i'd start at 50, see how it feels after a few days
04-07-2011, 01:24 PM
Will do. Seems everything I've read has stated that your body unfortunately will eventually exhibit downregulation of ANY AI that you are using. Which means taking them for long term, such as when they are given for a few years on end to breast cancer patients makes them slightly less effective over time.
Truth to this?
04-07-2011, 01:32 PM
I think like anything its somewhat individual, and somewhat dose dependent. But overall yes, your body always seeks homeostasis
04-07-2011, 01:57 PM
Ok, first of all, what are your vitamin D levels? If your LH level is sufficient and you are SURE that your testes are working, then vitamin D can OFTEN be the culprit, especially since most of us are deficient. As for your estrogen question, everyone is different in regards to what their body can handle. For instance, I may have an estrogen reading of 30, which is just slightly above "optimal" but bc my SHBG is so low, I can't even handle that much without libido issues....In summary, post some bloods and get some definitive advice. You could well be on a good track by taking an AI, as this is all that I need in my specific situation to shoot my T and libido up, but you WANT to be sure. Also, there are effective legal OTC AIs that you can get that are cheap.
04-07-2011, 02:47 PM
04-07-2011, 03:12 PM
04-07-2011, 03:13 PM
04-07-2011, 06:01 PM
Half life of aromasin is 27 hours correct?
That's what I've read multiple times before, however some broscience posts have also stated that it's 27 hours in women, but only 7 1/2 in men...why that would be I do not know...
edit: also it seems there is a misconception on whether the standard dose is 25mgs, or 25mcgs (which would be .25mg) Anybody wanna clear that up for me?
04-08-2011, 08:04 AM
04-08-2011, 09:28 AM
04-08-2011, 09:56 AM
04-08-2011, 10:18 AM
04-08-2011, 10:36 AM
04-08-2011, 07:03 PM
With in 2-3 weeks I would have all the answers I need to rule where the cause may be isolated. I have learned to take guessing games out of things with drs patients to get optimum response. Been doing this so long I can do it in my sleep
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