First off the argument made by many that IGF-1 LR3 is nothing more than a GDA is flawed. In order for IGF-1 LR3 to act that way it must be binding to an IGF-1 receptor and mediating events.
Now that I think real hard on it ...a long time ago in this thread I probably DID say that IGF-1 LR3 only acted as a GDA. I was wrong.
...and I think I have been very careful never to repeat the error, to research as much as possible and attempt to fully understand things.
IGF-1 LR3 is too small to stay in the extravascular space where it is injected and it will penetrate the vascular wall and travel systemically.
Some may bind to receptors where it is injected.
I have thought a lot about how I would try to make IGF-1 LR3 work if I used it by itself. Many have claimed that large doses gave them very noticeable local growth. But maybe one could split whatever dose is going to be used into 5 portions and pin in 5 areas in the worked muscle.
I have tried to interest a few research chem places into acquiring a small batch of IGF-1 prebound to IGFBP3 which when injected will immediately bind to ALS and end up being large enough to remain local...but in the end their suppliers couldn't come through.
But I am very open about people's experiences with IGF-1 LR3.
However when people want to combine IGF-1 LR3 with GH or GHRH+GHRPs I do have specific things to say about how they will interfere with one another.
I also fully understand and attempt to convey the importance of autocrine/paracrine IGF-1 & MGF and how testosterone & GH increase these growth factors.
Anyway I just wanted to clarify ...because Papa's statement made it sound like I was Razor Ripped (which is very, very, very anti-IGF-1 LR3) and that is simply not the case.
Your dream (and MINE!) is coming true, brother.
Originally Posted by datBtrue
I don't like that word because it isn't entirely accurate.
You mean does it work?
IGF-1 LR3 does bind to receptors ESPECIALLY those that "call for it" ...which is often wounded tissue.
It does travel systemically.
How much if any binds locally? There must be some benefit because almost everyone who has wounds they want to heal benefit by injecting near the wound.
However in order for systemic IGF-1 to become anabolic it needs to be in an amount equivalent to around 160ug.
But for therapeutic or contribution to wound healing the body needs very little. It only needs 300ng concentrated in the wounded area, if it is found in blood platelets aggregated around the wound which also contain:
...so the real question is "can you make IGF-1 LR3 behave anabolically?"
You're not going to get an accurate answer from people on the boards because there is no definitive answer. Enough people that know what they are doing say YES. Plenty of people that no what they are doing say NO.
My opinion is that it is the locally created/used IGFs that are important not systemic IGF-1. GH & testosterone increase the production of muscle IGFs. You don't need IGF-1 and it is a hindrance IF you are also using GH or GHRH+GHRP-6.
Again a post which sums things up only as DatBtrue can do it. Well done my friend.
I hate to beat a dead horse, but Grunt, I have quick question. I have been fairly chubby my whole life until the past ten or so years of lifting and eating right. I've pretty much uncovered through dietary manipulation that I'm pretty insulin insensitive. I start making any real progress in bulking and I tend to have a pretty significant spillover into fat. Consuming carbs of any appreciable amount tend to have an opposite effect of making me soft and flat rather than pumped up and solid.
I've been on a quest to chemically modify that particular effect. You mention that IGF shouldn't be used for anything other than boosting the new muscle growth within specific tissues. So should I just save my money if my main goal is to bulk without fattening up? You know, just sort of even the odds as it were? Looking for something that would accomplish this goal. Not looking for freak, just wanting my body to process carbs much better and prevent fat gain on a bulk.
Most I would do is 4 on 4 off, using it bilaterally in the muscle worked that day as soon as possible after your workout. That is pretty much Grunt's protocol. However, there are some vastly differing opinions now on the effectiveness of IGF-1 LR3 and muscle growth, so my opinion may not be worth much.
Hi grunt. I've already bought igf 1 lr3, but I'm to scared to make acetic acid by my self. Can you make that for me? Let me buy from you, I don't have any gym's doctor in my country. I just want to be save with the 0.6% acetic acid.. I'm too scared with the ingredients, which vinegar, how to make it sterile,etc,because I know it will inject directly to muscle, so I have to make sure that it is safety. My friend is going to my country for holiday,she lives in los angeles now. I really serious. I hope you can help.. Big big thanks!!
How much would ones work capacity increase while using IGF-1?
If i workout 3 days per week with short high intensity workouts and have poor recovery abilities. Should i add a couple more sets to each exercise or should i add another day or leave my routine alone?
Just wanted to say a quick thank you to Grunt for this highly informative thread!
I am stuck on one last supply, does anyone know where I can locate a reasonably priced small quantity of the sterile syringe filter(s) needed to make the AA? Thanks for your help! redmcs @ gmail dot com
I know you are supposed to take igf-1 immediately post workout and then consume nutrients. I want to do it pre-contest and I am on a keto diet. Can I stay with my usual whey protein shake and natty peanut butter post workout after the igf-1? or do I have to take in carbs?
I just stated taking igf 1 long r3 yesterday but not sure i did it correctly. I piched some stomach flab and shot at like a 30degree angle.
Also, i already have a pot belly of fat which is what i am trying to loose. Is this going to work or did i waste my time and money?
not an expert on igf-1 by any means, but to my knowledge, hgh is generally inj. sub-q in the lower abs.. igf-1 is best when site injected bi-laterally and intra musc. in the muscle group trained that day within 30 min. of completion of training. igf-1 is praised for site inj. muscle growth and killer pumps.. there is a ton of info. on it out there, if you do a search. for as much as it costs, i would read up before you use anymore.. so you get the best results for your buck-
Hey I have read through this thread so I think I am clear on all the info, but I just bought IGF LR3 and it was so damn expensive I just want to make sure I am doing this right. My bad I'm sure (especially Grunt76) is getting tired of answering these questions. I plan on doing 50mcg ED for 30 days. But my workout routine is Monday:Biceps Tuesday:Chest Wednesday:Back Thursday:Legs Friday:Shoulders Saturday:Chest. So you see I will be rotating my spots around so I will give my receptors a week to recover from the previous injection. I was told by the company to mix the IGF with BS water, but I have 15 vials of 100mcgs so after I add it I usually finish the vial around 24 hours, so I don't think degrading would occur too much. I am stacking this with tren and sust. Any input you have regarding my IGF use I would appreciate. Like I said I'm new to this and sorry to be such a pain in the ass, but I just want to make sure I am getting a good bang for my buck.
Much thanks to everyone especially Grunt for all the info.
Question: I ordered 1mg long R3 IGF-1 and the company that I bought it from sent sodium choride for reconstitution. Is this an acceptable solvent for injection? I am getting quite a bit of injection site pain and swelling. Also, is IGF-1 stable in sodium chloride? Will it degrade quickly in this solvent?