My take on IGF-1

[Hardgain]

Quote:
Originally Posted by Hardgain
Grunt, this is a great thread and the really great part is that it seems your hands have made a full recovery !! How are the quads looking ?


Fat, fat, fat everywhere. I stopped training, and am only now getting to where I'm planning my comeback to the gym. We'll see how that goes. Thanks for asking though.

It'll feel great ...............after it stops hurting

[mr athlete]

Grunt, great post. I have a couple of questions.

What would your body naturally produce of IGF on any given day if any? What would be the range? Would it be 5mcg. I am just trying to gain a percpective on how much we are injecting above our natural production.

[Grunt76]

Grunt, great post. I have a couple of questions.

What would your body naturally produce of IGF on any given day if any? What would be the range? Would it be 5mcg. I am just trying to gain a percpective on how much we are injecting above our natural production.

I have read that Dave Palumbo, the pro bodybuilder with 3 years of med school asserts that the amount of paracrine IGF-1 produced by a human body is in the 1mcg range. There should be broad fluctuations about this measurement, which surely must be a guesstimate.

[mr athlete]

Thanks, so even if its 2mcg per day were injecting apprx. 20xs normal production.

Assuming you have time, do you think going lower doses for longer periods would be a safer way to gaurd against intestinal growth and still get the positive results desired? Say 10-20mcg range?

[Grunt76]

Thanks, so even if its 2mcg per day were injecting apprx. 20xs normal production.

Assuming you have time, do you think going lower doses for longer periods would be a safer way to gaurd against intestinal growth and still get the positive results desired? Say 10-20mcg range?

Yes, there is a protocol developed by Palumbo wich does this.

I prefer the idea of doing 40mcg E3D though.

Both might be equally good and safe, for all I know.

[jminis]

Great discussion and info here consider this one a sticky.

[mr athlete]

Grunt one last ?. I assume when using IGF you are at risk of enlarging the heart? Does it have as much receptors as the intestines?

Assuming you are an endurance athlete or simply inject IGF after cardio could you be elevating the risk of enlarging your heart?

Thanks and this is one of the best threads I have read on IGF.

[jomi822]

from the studies i have read scientists postulate that myostatin and igf-1 present in cardiac muscle operate on completely separate pathway in comparison to skeletal muscle.

in other words, igf-1 and myostatin inhibition will not have the same effect on cardiac muscle as it does on skeletal muscle.

can you confirm this grunt? i havent seen any difinitive studies, and dont want to give out brotelligence

[ryano]

Good info grunt. Glad your getting better.

[Grunt76]

from the studies i have read scientists postulate that myostatin and igf-1 present in cardiac muscle operate on completely separate pathway in comparison to skeletal muscle.

in other words, igf-1 and myostatin inhibition will not have the same effect on cardiac muscle as it does on skeletal muscle.

can you confirm this grunt? i havent seen any difinitive studies, and dont want to give out brotelligence

I cannot confirm this, although I agree there is no evidence of any heart-enlarging effects. For example, Long R3 IGF-1 is used for kids with deficiencies and no heart size monitoring is ever done. Pubmed is at your disposal if you want to look into that aspect of it. I concentrated my studies on enhancing the local effect and lessening the systemic.

[preston25]

So the igf-1 is more effective than the lr3 version?

[Grunt76]

So the igf-1 is more effective than the lr3 version?

This whole thread is about Long R3 IGF-1. And no, hIGF-1 isn't more effective.

[preston25]

Thanks, Ive been using igf-1lr3 for some time now. EOD 25-40mcg with good results. I deffinitly notice that pee has a strange odor during my usage. Have you heard anything like this before?

[Grunt76]

Thanks, Ive been using igf-1lr3 for some time now. EOD 25-40mcg with good results. I deffinitly notice that pee has a strange odor during my usage. Have you heard anything like this before?

No. You are probably not human.

J/K. But I haven't heard of anything like that before...

[mr athlete]

preston25, if your carbs are low you may be in ketosis...happened to me first week.

[Grunt76]

preston25, if your carbs are low you may be in ketosis...happened to me first week.

Extremely smart reply, I say. Reps to you man.

[sandusky]

Note: I use "Hyperplasia" in the above posts, knowing it isn't the exact word for growth of new myoblasts. Close enough I guess.

how about "myoplasia"?

[skull]

this might be a huge wastse of money---but if you are willing --would it have any value as a TD?--also Im starting to think the pgf2a I bought wont work?

[Grunt76]

this might be a huge wastse of money---but if you are willing --would it have any value as a TD?--also Im starting to think the pgf2a I bought wont work?

I don't think there would be any way to make this work as a transdermal.

What's your pgf2a not doing? How are you using it?

[skull]

I don't think there would be any way to make this work as a transdermal.

What's your pgf2a not doing? How are you using it?

well its on its way but its supposed to be the only prod around that you can use as a TD to kill fat cells[ not just shrink]closesed thing to lipo and its also similar to igf as inject [site spec muscle growth]