My take on IGF-1

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  1. Great discussion and info here consider this one a sticky.


  2. Grunt one last ?. I assume when using IGF you are at risk of enlarging the heart? Does it have as much receptors as the intestines?

    Assuming you are an endurance athlete or simply inject IGF after cardio could you be elevating the risk of enlarging your heart?

    Thanks and this is one of the best threads I have read on IGF.
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  3. from the studies i have read scientists postulate that myostatin and igf-1 present in cardiac muscle operate on completely separate pathway in comparison to skeletal muscle.

    in other words, igf-1 and myostatin inhibition will not have the same effect on cardiac muscle as it does on skeletal muscle.

    can you confirm this grunt? i havent seen any difinitive studies, and dont want to give out brotelligence

  4. Good info grunt. Glad your getting better.

  5. Quote Originally Posted by jomi822
    from the studies i have read scientists postulate that myostatin and igf-1 present in cardiac muscle operate on completely separate pathway in comparison to skeletal muscle.

    in other words, igf-1 and myostatin inhibition will not have the same effect on cardiac muscle as it does on skeletal muscle.

    can you confirm this grunt? i havent seen any difinitive studies, and dont want to give out brotelligence
    I cannot confirm this, although I agree there is no evidence of any heart-enlarging effects. For example, Long R3 IGF-1 is used for kids with deficiencies and no heart size monitoring is ever done. Pubmed is at your disposal if you want to look into that aspect of it. I concentrated my studies on enhancing the local effect and lessening the systemic.
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  6. So the igf-1 is more effective than the lr3 version?

  7. Quote Originally Posted by preston25
    So the igf-1 is more effective than the lr3 version?
    This whole thread is about Long R3 IGF-1. And no, hIGF-1 isn't more effective.

  8. Thanks, Ive been using igf-1lr3 for some time now. EOD 25-40mcg with good results. I deffinitly notice that pee has a strange odor during my usage. Have you heard anything like this before?

  9. Quote Originally Posted by preston25
    Thanks, Ive been using igf-1lr3 for some time now. EOD 25-40mcg with good results. I deffinitly notice that pee has a strange odor during my usage. Have you heard anything like this before?
    No. You are probably not human.

    J/K. But I haven't heard of anything like that before...

  10. preston25, if your carbs are low you may be in ketosis...happened to me first week.

  11. Quote Originally Posted by mr athlete
    preston25, if your carbs are low you may be in ketosis...happened to me first week.
    Extremely smart reply, I say. Reps to you man.

  12. Quote Originally Posted by Grunt76
    Note: I use "Hyperplasia" in the above posts, knowing it isn't the exact word for growth of new myoblasts. Close enough I guess.
    how about "myoplasia"?

  13. this might be a huge wastse of money---but if you are willing --would it have any value as a TD?--also Im starting to think the pgf2a I bought wont work?

  14. Quote Originally Posted by skull
    this might be a huge wastse of money---but if you are willing --would it have any value as a TD?--also Im starting to think the pgf2a I bought wont work?
    I don't think there would be any way to make this work as a transdermal.

    What's your pgf2a not doing? How are you using it?

  15. Quote Originally Posted by Grunt76
    I don't think there would be any way to make this work as a transdermal.

    What's your pgf2a not doing? How are you using it?
    well its on its way but its supposed to be the only prod around that you can use as a TD to kill fat cells[ not just shrink]closesed thing to lipo and its also similar to igf as inject [site spec muscle growth]

  16. Quote Originally Posted by skull
    well its on its way but its supposed to be the only prod around that you can use as a TD to kill fat cells[ not just shrink]closesed thing to lipo and its also similar to igf as inject [site spec muscle growth]
    It is readily absorbed through the skin, so you should be fine.

  17. Quote Originally Posted by Grunt76
    It is readily absorbed through the skin, so you should be fine.
    one thing that didnt make sense--they say its got good potential as a TD fat burner---but not so good as TD spot [site spec]muscle builder---now if I put it on an area that has thin skin[no fat] like biceps--why would it not work?

  18. hey grunt you seem very knowlegable about this [pgf2a] and [igf-1]how do they compare ,I know they can be stacked--any personal ex?

  19. Quote Originally Posted by skull
    hey grunt you seem very knowlegable about this [pgf2a] and [igf-1]how do they compare ,I know they can be stacked--any personal ex?
    No I have yet to try pgf2a on myself. I will report when I do.

  20. Quote Originally Posted by Grunt76
    I cannot confirm this, although I agree there is no evidence of any heart-enlarging effects. For example, Long R3 IGF-1 is used for kids with deficiencies and no heart size monitoring is ever done. Pubmed is at your disposal if you want to look into that aspect of it. I concentrated my studies on enhancing the local effect and lessening the systemic.

    Virgin Cycle.... HGH alone? Igf-Lr3 alone? Mgf alone? HGH/IGFlr3? IGF/MGF? HGH/MGF????

  21. Quote Originally Posted by logan22
    Virgin Cycle.... HGH alone? Igf-Lr3 alone? Mgf alone? HGH/IGFlr3? IGF/MGF? HGH/MGF????
    They are all low-side-effect options bro, any of these is good.

    Some people will say that you should start with AAS (even the semi-legal ones) before the peptides, but I like peptides for a first-timer, because they are low on sides and their effects are more subtle.

  22. Quote Originally Posted by Grunt76
    They are all low-side-effect options bro, any of these is good.

    Some people will say that you should start with anabolic steroids (even the semi-legal ones) before the peptides, but I like peptides for a first-timer, because they are low on sides and their effects are more subtle.
    My thoughts exactly. (Going to try lr3-igf1 as a first timer). Thanks for all the info Grunt!

  23. Quote Originally Posted by Grunt76
    They are all low-side-effect options bro, any of these is good.

    Some people will say that you should start with anabolic steroids (even the semi-legal ones) before the peptides, but I like peptides for a first-timer, because they are low on sides and their effects are more subtle.

    Thanks again. Do you think I would need to use some GH or do you think if I added some cytomel I would get just as good of the fat burning properties?

  24. hey grunt I notice you recomend the rhIGF-1 [in other thread]because it stays more local at doses over 50mcg --but for a firstimer-- as long as you keep dosage under 50mcg, would the long give more bang for the buck?and not give coleman gut?

  25. Quote Originally Posted by logan22
    Thanks again. Do you think I would need to use some GH or do you think if I added some cytomel I would get just as good of the fat burning properties?
    I'm not sure what you are referring to... GH & T3 or what? GH is synergistic with T4 BTW, which is gentle and nice, unlike T3. But I am uncertain as to the actual question still, so I stop here.

    Quote Originally Posted by skull
    hey grunt I notice you recomend the rhIGF-1 [in other thread]because it stays more local at doses over 50mcg --but for a firstimer-- as long as you keep dosage under 50mcg, would the long give more bang for the buck?and not give coleman gut?
    Nope I don't recommend rhIGF-1.
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